Cleft lip and Palate Incidence Among the Live Births in the Republic of Korea

Abstract BACKGROUND Encephaloceles are herniations of intracranial neural tissue and meninges through defects in the skull. Basal encephaloceles are rare anterior skull base defects incident in 1 in 35,000 live births. Sphenoethmoidal encephaloceles are even more uncommon, with an incidence of 1 in 700,000 live births. Anterior skull base encephaloceles may be life-threatening in infants, presenting as airway obstruction and respiratory compromise. They can also present with cerebrospinal fluid (CSF) rhinorrhea, purulent nasal drainage, or meningitis. OBJECTIVE To report a novel technique for repairing a giant sphenoethmoidal encephalocele containing eloquent neural tissue. METHODS A 16-mo-old girl presented with progressive airway obstruction from a giant sphenoethmoidal encephalocele that filled her oral cavity. She had multiple congenital anomalies including agenesis of the corpus callosum and cleft lip and palate. Computed tomography showed complete absence of the bony anterior cranial base, and magnetic resonance imaging demonstrated the presence of the pituitary gland and hypothalamus in the hernia sac. RESULTS We repaired the encephalocele using a combined microsurgical and endoscopic multidisciplinary approach working through transcranial, transnasal, and transpalatal corridors. The procedure was completed in a single stage, during which the midline cleft lip was also repaired. The child made an excellent neurological and aesthetic recovery with preservation of pituitary and hypothalamic function, without evidence of CSF fistula. CONCLUSION The authors describe a novel multidisciplinary technique for treating a giant sphenoethmoidal encephalocele containing eloquent brain. The cleft lip was also repaired at the same time. The ability to work through multiple corridors can enhance the safety and efficacy of an often-treacherous operative endeavor.

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Congenital cleft lip and palate in children from Tajikistan in 2009–2019

Aspirantskiy Vestnik Povolzhiya ◽

10.17816/2072-2354.2020.20.1.75-79 ◽

2020 ◽

Vol 20 (1-2) ◽

pp. 75-79

Author(s):

Abdugafor Z. Abdurahmonov

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Medical Center ◽

Archival Data ◽

Number Of Children ◽

National Medical ◽

Outpatient Visits ◽

Congenital Cleft ◽

The Republic

We analyzed the dynamics of congenital cleft lip and palate in children and studied the archival data of the National Medical Center Shifobakhsh (Dushanbe) of the Republic of Tajikistan on the incidence of outpatient visits due to this abnormality in the Republic of Tajikistan over the period from 2009 to 2019. The number of children born with congenital cleft has been increasing for the last ten years. We found out this pathology to develop in families with in-and-in marriage, it also depends upon the sex of a child. Boys are more prone to maxillofacial anomalies.

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Surgical management of palatal teratoma (epignathus) with the use of virtual reconstruction and 3D models: a case report and literature review

Archives of Plastic Surgery ◽

10.5999/aps.2021.00318 ◽

2021 ◽

Vol 48 (5) ◽

pp. 518-523

Author(s):

Cynthia Minerva Gonzalez-Cantu ◽

Pablo Juan Moreno-Peña ◽

Mayela Guadalupe Salazar-Lara ◽

Pablo Patricio Flores García ◽

Fernando Félix Montes-Tapia ◽

...

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Surgical Intervention ◽

Mature Teratoma ◽

3D Models ◽

Bloc Resection ◽

3 Dimensional ◽

Live Births ◽

Virtual Reconstruction ◽

Adjacent Structures

Epignathus is a rare congenital orofacial teratoma that arises from the sphenoid region of the palate or the pharynx. It occurs in approximately 1:35,000 to 1:200,000 live births representing 2% to 9% of all teratomas. We present the case of a newborn of 39.4 weeks of gestation with a tumor that occupied the entire oral cavity. The patient was delivered by cesarean section. Oral resection was managed by pediatric surgery. Plastic surgery used virtual 3-dimensional models to establish the extension, and depth of the tumor. Bloc resection and reconstruction of the epignathus were performed. The mass was diagnosed as a mature teratoma associated with cleft lip and palate, nasoethmoidal meningocele that conditions hypertelorism, and a pseudomacrostoma. Tridimensional technology was applied to plan the surgical intervention. It contributed to a better understanding of the relationships between the tumor and the adjacent structures. This optimized the surgical approach and outcome.

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Prevalence of Cleft Lip/Palate in the Fangshan District of Beijing, 2006-2012

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665618767115 ◽

2018 ◽

Vol 55 (9) ◽

pp. 1296-1301 ◽

Cited By ~ 2

Author(s):

Yanfen Yang ◽

Hui Liu ◽

Ruixin Ma ◽

Lei Jin

Keyword(s):

Data Analysis ◽

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Upward Trend ◽

Live Births ◽

Cleft Lip Palate ◽

Obstetric Services ◽

Permanent Residents ◽

Beijing China

Objective: To estimate the cleft lip with or without cleft palate (CL/P) prevalence among births between 2006 and 2012 in Fangshan district of Beijing, China. Design: Surveillance data analysis. Setting: All hospitals that provide obstetric services in the district. Patients: The CL/P cases presented for this report were from 13 weeks’ gestation to 7 days postpartum. Main Outcome Measures: The CL/P prevalence was defined as the number of cases per 10 000 births, including live births and stillbirths at 28 weeks’ gestation or beyond. Results: The overall CL/P prevalence was 18.9 (95% confidence interval [CI]: 15.1-22.7) per 10 000 births. From 2006 to 2012, the CL/P prevalence was 19.3, 20.2, 10.9, 16.1, 17.5, 25.4, and 22.3 per 10 000 births; annually, no significant change was noted ( Pfor trend = .311). The prevalence of cleft palate, cleft lip, and cleft lip and palate were 3.4 (95% CI: 2.0-5.4), 6.2 (95% CI: 4.2-8.8), and 9.4 (95% CI: 6.9-12.4) per 10 000 births, respectively. The CL/P prevalence among the nonpermanent residents (31.4 per 10 000 births) was 2.31 times that of permanent residents (13.6 per 10 000 births). Among nonpermanent residents, the CL/P prevalence showed an upward trend over the study period ( Pfor trend = .036), that increased from 38.8 (95% CI: 16.5-76.6) per 10 000 births in 2006 to 54.6 (95% CI: 25.7-100.4) per 10 000 births in 2012. Conclusions: The overall CL/P prevalence was stable in the Fangshan district. However, the CL/P prevalence of the nonpermanent residents increased significantly.

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Lobar Holoprosencephaly with a Median Cleft: Case Report

The Cleft Palate-Craniofacial Journal ◽

10.1597/08-059.1 ◽

2009 ◽

Vol 46 (5) ◽

pp. 549-554 ◽

Cited By ~ 7

Author(s):

Elżbieta Gawrych ◽

Joanna Janiszewska-Olszowska ◽

Anna Walecka ◽

Maria Syryńska ◽

Hanna Chojnacka

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Brain Abnormalities ◽

Facial Deformity ◽

Unique Case ◽

Craniofacial Malformations ◽

Live Births ◽

Facial Defects ◽

Median Cleft

Holoprosencephaly is a congenital abnormality of the prosencephalon associated with median facial defects. Its frequency is 1 in 250 pregnancies and 1 in 16,000 live births. The degree of facial deformity usually correlates with the severity of brain malformation. Early mortality is prevalent in severe forms. This report presents a child with lobar holoprosencephaly accompanied by median cleft lip and palate. The treatment and 9 months’ follow-up are presented. This unique case shows that holoprosencephaly may present different manifestations of craniofacial malformations, which are not always parallel to the severity of brain abnormalities. Patients with mild to moderate brain abnormalities may survive into childhood and beyond.

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Incidence of Orofacial Clefts in Kumasi, Ghana

ISRN Plastic Surgery ◽

10.5402/2013/280903 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 1

Author(s):

P. Agbenorku ◽

M. Yore ◽

K. A. Danso ◽

C. Turpin

Keyword(s):

Cleft Palate ◽

Congenital Anomalies ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Orofacial Clefts ◽

Female Ratio ◽

Live Births ◽

Male Female Ratio ◽

Cleft Lip Palate ◽

History Of

Background. Cleft lip and cleft palate are among the most common orofacial congenital anomalies. This study is to establish Orofacial Clefts Database for Kumasi, Ghana, with a view to extend it to other cities in future to obtain a national orofacial anomaly database. Methods. A descriptive prospective survey was carried out at eleven selected health facilities in Kumasi. Results. The total number of live births recorded was 27,449. Orofacial anomalies recorded were 36, giving an incidence of 1.31/1000 live births or 1 in 763 live births. The mean maternal age of cleft lip/palate babies was 29.85 years (range 18–40 years). The male : female ratio for the orofacial anomalies babies was 1.3 : 1; the male : female ratio was 0.5 : 1 in the cleft lip group, 1.3 : 1 in the cleft lip and palate group, and 4 : 1 in the cleft palate group. The majority of clefts were unilateral (69.4%, n=25), with females (n=14) outnumbering males (n=11). A family history of cleft was recorded with five babies (13.9%). Associated congenital anomalies were recorded in seven (19.4%) cleft lips and/or palates. Conclusion. The incidence of 1 in 763 live births found in this study indicates that cleft lip/palate is a common congenital anomaly in Kumasi.

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Association of other congenital anomalies in children with cleft lip and palate: a prospective hospital based observational study

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20191072 ◽

2019 ◽

Vol 6 (3) ◽

pp. 1059

Author(s):

Padmasani Venkat Ramanan ◽

Rajesh Balan ◽

Jyotsna Murthy ◽

Syed Altaf Hussain

Keyword(s):

Congenital Anomaly ◽

Congenital Anomalies ◽

Congenital Malformations ◽

Congenital Heart ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Associated Anomalies ◽

Live Births ◽

Associated Malformations ◽

Syndrome Association

Background: Cleft lip and palate is a common congenital anomaly affecting approximately 1 in 700 live births in south Asia. It is often associated with syndromes and other malformations but the exact incidence of these in Asians is not known. The present study was carried out to determine the association of other congenital anomalies in children with cleft.Methods: The study was carried out in the patients attending the Cleft centre of our Hospital. They were examined for other major external congenital malformations and syndrome association. Where ever relevant, appropriate investigations were done.Results: Of the total of 2367 children examined, 262 (11.06%) had congenital malformations. Among the non-syndromic children, 9% had associated malformations. The commonest was congenital heart disease (1.4%) following by genitourinary and skeletal anomalies. The highest number of anomalies was seen in patients with cleft palate alone (24.89%). 1.4% patients had identifiable syndromes.Conclusions: The study emphasizes the need for a thorough examination of all children with cleft. The overall lower incidence of syndromic clefts and associated anomalies in present study suggests that other etiological factors may be involved in our country.

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Cleft Lip and Palate in Tehran

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_1992_029_0015_clapit_2.3.co_2 ◽

1992 ◽

Vol 29 (1) ◽

pp. 15-16 ◽

Cited By ~ 5

Author(s):

Abbas A.Y. Taher

Keyword(s):

Cleft Palate ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Sulfur Mustard ◽

Mustard Gas ◽

Live Births ◽

Bilateral Cleft Lip

Seventy-nine cleft lip and/or palate births were isolated from 21,138 live births between January 1, 1983 and December 31, 1988 in one hospital in Tehran. Among these, 21 (26.58 percent) were cleft lip (CL), 45 (56.96 percent) were cleft lip and palate (CLP), and 13 (16.45 percent) were cleft palate (CP). Chemical sulfur mustard gas was indicated as a major factor in 30 (37.97 percent) of the bilateral cleft lip and palate infants.

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Analysis of the Prevalence and Incidence of Cleft Lip and Palate in Colombia

The Cleft Palate-Craniofacial Journal ◽

10.1177/1055665619886455 ◽

2019 ◽

Vol 57 (5) ◽

pp. 552-559 ◽

Cited By ~ 2

Author(s):

Rengifo Reina Herney Alonso ◽

Guarnizo Peralta Stefany Brigetty

Keyword(s):

Cleft Lip ◽

Cleft Lip And Palate ◽

Cross Sectional Study ◽

Cross Sectional ◽

Oral Clefts ◽

Birth Prevalence ◽

Administrative Records ◽

Live Births ◽

Population Prevalence ◽

The Individual

Objective: To analyze the population prevalence and birth prevalence of oral clefts in Colombia from 2009 to 2017. Methods: A cross-sectional study using information from the National Administrative Records of Colombia. The data came from 2 types of administrative records (Surveillance System and the Individual Registry of Service Provision) and the oral health national survey. Population prevalence and birth prevalence by type of cleft lip and/or cleft (CL/P) ratios were calculated using Poisson distribution for count data and to assess stationary tests on time series (Dickey-Fuller) and (Phillips-Perron) was used. Results: Population prevalence in Colombia was 3.27 per 10 000 inhabitants (95% confidence interval [CI], 3.21-3.32) and birth prevalence was 6.0 per 10 000 live births (95% CI, 5.67-6.35). Bogotá have the highest population prevalence with CL/P. In the analysis of trends for the prevalence proportion by type of clefts in newborn babies with cleft, it was observed that the highest proportion was for babies with CLP. Cleft lip (CL) has increased from 17.4% in 2014 to 34.2% in 2017, cleft palate (CP) has decreased from 32.9% to 20.2%; and CLP changed from 49.6% to 45.5% in the same period. Conclusions: The population prevalence was 3.27 per 10 000 inhabitants. Births prevalence was 6.0 per 10 000 live births, and Orinoquia and Amazonia have higher rates than the national average. The administrative registers are adequate systems to know the behavior of oral clefts. The CL/P had a nonstationary trend during the period 2014 to 2017.

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Incidence of Cleft Lip and Palate and Risks of Additional Malformations

The Cleft Palate-Craniofacial Journal ◽

10.1597/1545-1569_1998_035_0040_ioclap_2.3.co_2 ◽

1998 ◽

Vol 35 (1) ◽

pp. 40-45 ◽

Cited By ~ 41

Author(s):

Catharina Hagberg ◽

Ola Larson ◽

Josef Milerad

Keyword(s):

Birth Weight ◽

Birth Defects ◽

Cleft Lip ◽

Cleft Lip And Palate ◽

Live Births ◽

Different Types ◽

Mother’S Age ◽

Rate Ratios ◽

Isolated Cleft Palate ◽

Similar Incidence

Objective and Methods Children with cleft lip and/or palate (n = 251) born between 1991 and 1995 in the county of Stockholm, Sweden, were studied with reference to incidence and rate ratios (RRs) of different types of clefts, gender, birth weight, mother's age, and length of pregnancy. Children who had clefts and additional malformations were compared with children who had clefts but no additional malformations. Results The incidence of clefts was 2.0/1000 live births, and it was higher among males than among females. The RR, an index of relative risk, was 1.58. The main groups, children with isolated cleft lip, children with cleft lip and palate, and children with isolated cleft palate, showed similar incidence values (0.6-0.7/1000 live births). Children with bilateral clefts had an incidence of 0.3/1000 live births. Additional malformations were found in approximately every sixth newborn with a cleft when children with Robin sequence were excluded. There was a tendency for newborns with bilateral clefts to have additional malformations (RR = 1.36; confidence interval = 0.74-2.49). Children with clefts and additional malformations had lower birth weight and were born earlier than children with clefts only. Conclusion Preterm cleft children with low birth weight should be screened for the presence of other birth defects.

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