A Case of Extravesical Metastases Occurring after Transurethral Resection of Non-Invasive Bladder Cancer

Introduction: The thulium laser resection of bladder tumors (TmLRBT) was increasingly used in the treatment of non-muscle-invasive bladder cancer (NMIBC) recently, and here we report the relevant outcomes of our institution to evaluate its efficacy and safety. Methods: We retrospectively collected the data of NMIBC patients who underwent either TmLRBT or transurethral resection of bladder tumor (TURBT). The baseline characteristics and perioperative outcomes were compared in these 2 groups. Results: The TmLRBT had a higher rate of detrusor identification than TURBT (97.4 vs. 87.6%, p = 0.001). After screening, 134 patients who underwent TmLRBT and 152 patients who received TURBT were enrolled in the analysis, and their baseline characteristics were similar. During the TURBT, 24 (15.8%) obturator nerve reflexes and 9 (5.9%) bladder perforations occurred, while none happened during the TmLRBT. After surgery, TmLRBT patients had fewer postoperative gross hematuria (38.1 vs. 96.7%, p < 0.001) and postoperative irrigation (27.6 vs. 92.7%, p < 0.001), and its irrigation duration was significantly shorter (2.3 vs. 3.3 day, p < 0.001). During the follow-up, no significant difference in the recurrence rate was detected (p = 0.315). Conclusions: TmLRBT is a safer technique than conventional TURBT in the treatment of NMIBC, and it could offer better specimens for pathologic assessment while the cancer control was not compromised.

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Transurethral Resection of Non–muscle-invasive Bladder Cancer

European Urology Supplements ◽

10.1016/j.eursup.2009.06.003 ◽

2009 ◽

Vol 8 (7) ◽

pp. 542-548 ◽

Cited By ~ 32

Author(s):

Marko Babjuk

Keyword(s):

Bladder Cancer ◽

Transurethral Resection ◽

Invasive Bladder Cancer ◽

Muscle Invasive Bladder Cancer ◽

Muscle Invasive

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C108 ADJUVANT INSTILLATION THERAPY IN THE TREATMENT OF NON-MUSCLE INVASIVE BLADDER CANCER DURING THE FIRST TWO YEARS AFTER TRANSURETHRAL RESECTION

European Urology Supplements ◽

10.1016/s1569-9056(10)61633-8 ◽

2010 ◽

Vol 9 (6) ◽

pp. 646 ◽

Cited By ~ 1

Author(s):

V. Petcu ◽

P. Rotariu ◽

F. Dinca ◽

D. Sarb ◽

G. Crisan

Keyword(s):

Bladder Cancer ◽

Transurethral Resection ◽

Invasive Bladder Cancer ◽

Muscle Invasive Bladder Cancer ◽

Instillation Therapy ◽

Muscle Invasive

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Evaluation of the Efficacy of Solifenacin for Preventing Catheter-Related Bladder Discomfort After Transurethral Resection of Bladder Tumors in Patients With Non-Muscle Invasive Bladder Cancer: A Prospective, Randomized, Multicenter Study

Clinical Genitourinary Cancer ◽

10.1016/j.clgc.2016.05.006 ◽

2017 ◽

Vol 15 (1) ◽

pp. 157-162 ◽

Cited By ~ 2

Author(s):

Jae Min Chung ◽

Hong Koo Ha ◽

Dae Hyun Kim ◽

Jungnam Joo ◽

Sohee Kim ◽

...

Keyword(s):

Bladder Cancer ◽

Multicenter Study ◽

Transurethral Resection ◽

Invasive Bladder Cancer ◽

Bladder Tumors ◽

Muscle Invasive Bladder Cancer ◽

Muscle Invasive

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Trimodality bladder-sparing approach versus radical cystectomy for invasive bladder cancer

Journal of Radiotherapy in Practice ◽

10.1017/s1460396914000107 ◽

2014 ◽

Vol 13 (4) ◽

pp. 428-437 ◽

Cited By ~ 5

Author(s):

Samy M. AlGizawy ◽

Hoda H. Essa ◽

Mostafa E. Abdel-Wanis ◽

Ahmed M. Abdel Raheem

Keyword(s):

Bladder Cancer ◽

Radical Cystectomy ◽

Phase Ii ◽

Transurethral Resection ◽

Residual Disease ◽

Bladder Tumour ◽

Phase Iii ◽

Invasive Bladder Cancer ◽

Combined Modality ◽

Combined Chemoradiotherapy

AbstractPurposeTo compare the outcome among patients with invasive bladder cancer treated with cystectomy alone with outcome among those treated with combined-modality treatment in a randomised phase III trial.Patients and methodsPatients with histologically confirmed invasive non-metastatic bladder cancer T2-3, N0 and M0 were randomly assigned to two arms: Arm 1: of which all patients underwent radical cystectomy (RC) alone; and Arm 2, of which all patients were subjected to maximal transurethral resection of bladder tumour, followed 2 weeks later by combined chemoradiotherapy. The whole pelvis received 46 Gy in 23 fractions over 4·5 weeks. Chemotherapy was administered concomitantly with radiotherapy with: cisplatin 70 mg/m2 q. 3 weeks and Gemcitabine 300 mg/m2 D 1, 8 and 15 q. 3 weeks for two cycles. Patients who had complete response were shifted to phase II treatment: 20 Gy/10 fractions/2 weeks to the bladder. Patients with residual tumour underwent RC.ResultsOf the 80 patients assigned Arm 2, a visibly completed transurethral resection of the bladder tumour was possible in 48 patients (60%). Phase I of combined chemoradiotherapy (CCRT) was accomplished in 74 patients. Post-induction urologic evaluation revealed no evidence of disease in 62 patients (83·8%) and residual disease in 12 patients (16·2%). Phase II of CCRT was completed in 58 of the 62 patients. The median follow-up for all patients is 27 months (range: 4–49). The 3-year overall survival (OS) for the combined-modality group and for the surgery group were 61 and 63%, respectively (p = 0·425), whereas the disease-specific survival (DSS) for each group was 69 and 73%, respectively (p = 0·714). The 3-year OS with bladder preservation for Arm 2 patients was 50%.Multivariate analysis for the whole series showed that tumour stage and performance status (PS) were the only factors independently associated with DSS, although PS was the only factor independently associated with OS. In addition, residual disease after transurethral resection of the bladder tumour in Arm 2 patients was independently associated with both DSS and OS.Acute toxicity was moderate and most of the late toxicities were grade 2 with no grade 4 toxicity and no treatment-related deaths, none required cystectomy for bladder contraction.ConclusionThis study demonstrates that trimodality bladder-preserving approach represents a valid alternative for suitable patients. The OS and DSS rates of patients treated with trimodality bladder-preserving protocol are comparable to the results reported on patients treated with immediate radical cystectomy.

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