The cut-off value of ADC to differentiate benign from malignant breast lesions

Summary Aim: Our goal was to determine the clinical usefulness of TI-201 to identify breast cancer in patients with suspicious breast lesions on clinical examination, and/or abnormal radiologic (mammography and/or ultrasonography) findings. Methods: TI-201 scintigraphy were performed in sixty-eight patients with 70 breast abnormalities (51 palpable, 19 nonpalpable) and compared with mammography and ultrasonography (US). Early (15 min) and late (3 h) images of the breasts were obtained following the injection of 111 MBq (3 mCi) of TI-201. Visual and semiquantitative interpretation was performed. Results: Final diagnosis confirmed 52 malignant breast lesions and 18 benign conditions. TI-201 visualized 47 of 52 (90%) overall malignant lesions. Thirty-eight of 40 (95%) palpable and 9 of 12 (75%) nonpalpable breast cancers were detected by TI-201 scintigraphy. The smallest mass lesion detected by TI-201 measured 1.5x1.0 cm. Eleven breast lesions were interpreted as indeterminate by mammography and/or sonography. TI-201 scintigraphy excluded malignancy in 7 of 8 (88%) patients with benign breast lesions interpreted as indeterminate. Five of the 18 (28%) benign breast lesions showed TI-201 uptake. None of the fibroadenoma and fibrocystic changes accumulated TI-201. TI-201 scintigraphy, mammography and ultrasonography showed 90%, 92%, 85% overall sensitivity and 72%, 56%, 61% overall specificity respectively. Twenty-one of the 28 (75%) axillary nodal metastatic sites were also detected by TI-201. In malignant and benign lesions, early and late lesion/contralateral normal side (L/N) ratios were 1.58 ± 0.38 (mean ± SD) and 1.48 ± 0.32 (p >0.05), 1.87 ± 0.65 and 1.34 ± 0.20 (p<0.05) respectively. The mean early and late L/N ratios of malignant and benign groups did not show statistical difference (p>0.05). Conclusion: Overall, TI-201 scintigraphy was the most specific of the three methods and yielded favourable results in palpable breast cancers, while it showed lower sensitivity in nonpalpable cancers and axillary metastases. Combined use of TI-201 scintigraphy with mammography and US seems to be useful in difficult cases, such as dense breasts and indeterminate breast lesions.

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The Role of the Use of US-guided Vacuum-Assisted Breast Biopsy for the Total Removal of Sonographic Evidence in Low- and High-Risk Benign and Malignant Breast Lesions

Journal of the Korean Radiological Society ◽

10.3348/jkrs.2007.57.1.89 ◽

2007 ◽

Vol 57 (1) ◽

pp. 89

Author(s):

Hyon-Joo Kwag ◽

Shin-Ho Kook

Keyword(s):

High Risk ◽

Breast Biopsy ◽

Breast Lesions ◽

Total Removal ◽

Malignant Breast

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Amplification of HER-2 Gene in Benign and Malignant Breast Lesions in a Sample of Iraqi Women

Diyala Journal of Medicine ◽

10.26505/djm.13023430601 ◽

2017 ◽

Vol 13 (2) ◽

pp. 35-39

Author(s):

Maysoon Abdul-Ameer Ahmed Al-Salman ◽

◽

Risala Hussain Allami ◽

Lamyaa H. M. Al-Ibrahimi

Keyword(s):

Breast Lesions ◽

Malignant Breast ◽

Iraqi Women ◽

Her 2

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Computer Aided Classification of Benign and Malignant Breast Lesions using Maximum Response 8 Filter Bank and Genetic Algorithm

2020 IEEE REGION 10 CONFERENCE (TENCON) ◽

10.1109/tencon50793.2020.9293928 ◽

2020 ◽

Author(s):

Chiranjib Bhowmick ◽

Pranab Kumar Dutta ◽

Manjunatha Mahadevappa

Keyword(s):

Genetic Algorithm ◽

Filter Bank ◽

Maximum Response ◽

Breast Lesions ◽

Computer Aided ◽

Malignant Breast

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Can measuring perilesional tissue stiffness and stiff rim sign improve the diagnostic performance between benign and malignant breast lesions?

Journal of Medical Ultrasonics ◽

10.1007/s10396-020-01064-0 ◽

2021 ◽

Vol 48 (1) ◽

pp. 53-61

Author(s):

Wen-tao Kong ◽

Yin Wang ◽

Wei-jun Zhou ◽

Yi-dan Zhang ◽

Wen-ping Wang ◽

...

Keyword(s):

Diagnostic Performance ◽

Breast Lesions ◽

Tissue Stiffness ◽

Malignant Breast

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Elastic Modulus and Elasticity Ratio of Malignant Breast Lesions with Shear Wave Ultrasound Elastography: Variations with Different Region of Interest and Lesion Size

Diagnostics ◽

10.3390/diagnostics11061015 ◽

2021 ◽

Vol 11 (6) ◽

pp. 1015

Author(s):

Antonio Bulum ◽

Gordana Ivanac ◽

Eugen Divjak ◽

Iva Biondić Špoljar ◽

Martina Džoić Dominković ◽

...

Keyword(s):

Elastic Modulus ◽

Shear Wave ◽

Large Diameter ◽

Small Diameter ◽

Shear Wave Elastography ◽

Lesion Size ◽

Ultrasound Elastography ◽

Breast Lesions ◽

Malignant Breast ◽

The Impact

Shear wave elastography (SWE) is a type of ultrasound elastography with which the elastic properties of breast tissues can be quantitatively assessed. The purpose of this study was to determine the impact of different regions of interest (ROI) and lesion size on the performance of SWE in differentiating malignant breast lesions. The study included 150 female patients with histopathologically confirmed malignant breast lesions. Minimal (Emin), mean (Emean), maximal (Emax) elastic modulus and elasticity ratio (e-ratio) values were measured using a circular ROI size of 2, 4 and 6 mm diameters and the lesions were divided into large (diameter ≥ 15 mm) and small (diameter < 15 mm). Highest Emin, Emean and e-ratio values and lowest variability were observed when using the 2 mm ROI. Emax values did not differ between different ROI sizes. Larger lesions had significantly higher Emean and Emax values, but there was no difference in e-ratio values between lesions of different sizes. In conclusion, when measuring the Emin, Emean and e-ratio of malignant breast lesions using SWE the smallest possible ROI size should be used regardless of lesion size. ROI size has no impact on Emax values while lesion size has no impact on e-ratio values.

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Contrast-enhanced ultrasound of breast fibromatosis: a case report

Journal of International Medical Research ◽

10.1177/03000605211010619 ◽

2021 ◽

Vol 49 (5) ◽

pp. 030006052110106

Author(s):

Shanhong Lin ◽

Yong Cao ◽

Libin Chen ◽

Mei Chen ◽

Shengmin Zhang ◽

...

Keyword(s):

Breast Cancer ◽

Rare Case ◽

Common Type ◽

Breast Lesions ◽

Contrast Enhanced Ultrasound ◽

High Similarity ◽

Potential Value ◽

Contrast Enhanced ◽

Malignant Breast ◽

Contrast Enhanced Ultrasonography

We herein present a rare case of breast fibromatosis, the contrast-enhanced ultrasonography (CEUS) findings of which we believe have never been described. The high similarity between the clinical and imaging manifestations of breast cancer makes its differential diagnosis difficult. In this report, we describe the CEUS findings of a less common type of fibromatosis, discuss the potential value of CEUS to differentiate it from malignant breast lesions, and briefly review the literature.

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