Time to enhancement derived from ultrafast breast MRI as a novel parameter to discriminate benign from malignant breast lesions

2017 ◽  
Vol 89 ◽  
pp. 90-96 ◽  
Author(s):  
Roel D. Mus ◽  
Cristina Borelli ◽  
Peter Bult ◽  
Elisabeth Weiland ◽  
Nico Karssemeijer ◽  
...  
Keyword(s):  
Breast Mri ◽  
Breast Lesions ◽  
Malignant Breast

scholarly journals Diagnostic Accuracy of Contrast-Enhanced MRI for Detecting the Malignant Breast Lesions

2021 ◽  
Vol 25 (1) ◽  
pp. 26-30
Author(s):  
Naila Parveen ◽  
Rabia Waseem Butt ◽  
Manal Niazi ◽  
Kulsoom Iqbal ◽  
Sidra Manzoor ◽  
...  
Keyword(s):  
Imaging Modality ◽  
Breast Mri ◽  
Breast Lesions ◽  
Mri Imaging ◽  
Sample Collection ◽  
Cross Sectional ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Malignant Breast ◽  
Contrast Enhanced Mri

Objectives: To determine the accuracy of contrast-enhanced MRI in the diagnosis and detection of breast lesions and their malignant potential by taking the gold standard of histopathology.Materials and Methods: This study was conducted at the Department of Diagnostic Radiology, Pakistan Institute of Medical Sciences (P.I.M.S.) Islamabad. It was undertaken in collaboration with the Department of General Surgery P.I.M.S, Department of Pathology P.I.M.S Islamabad, and HIT Hospital Taxila. The study design was a cross-sectional (Validation) study and the duration of the study was 6 months (from 01-Oct-2016 to 31-Mar-2017). Results: Sample size was calculated by using sensitivity and specificity calculator taking sensitivity 94%1 with a precision of 6%, specificity 85%1 with a precision of 10%, prevalence is 45.9%2, and confidence interval of 95% it comes out to be 92%. Sample collection was made by the technique of Consecutive non-probability sampling.Conclusion: Breast MRI imaging is a modern evolving modality. A gradual increase in diagnostic specificity is achieved with improved software and techniques. More such studies would help develop confidence in this advanced imaging modality for improving patient management and avoiding unnecessary biopsies.

201Tl Scintigraphy in the Evaluation of Palpable and Nonpalpable Breast Lesions: Correlation with Mammography and Ultrasonography

1997 ◽  
Vol 36 (08) ◽  
pp. 282-288 ◽  
Author(s):  
T. Atasever ◽  
A. Özdemir ◽  
I. Öznur ◽  
N. I. Karabacak ◽  
N. Gökçora ◽  
...  
Keyword(s):  
Final Diagnosis ◽  
Lower Sensitivity ◽  
Breast Lesions ◽  
Breast Cancers ◽  
Combined Use ◽  
Malignant Breast ◽  
Malignant Lesions ◽  
Benign Breast Lesions ◽  
Palpable Breast ◽  
Metastatic Sites

Summary Aim: Our goal was to determine the clinical usefulness of TI-201 to identify breast cancer in patients with suspicious breast lesions on clinical examination, and/or abnormal radiologic (mammography and/or ultrasonography) findings. Methods: TI-201 scintigraphy were performed in sixty-eight patients with 70 breast abnormalities (51 palpable, 19 nonpalpable) and compared with mammography and ultrasonography (US). Early (15 min) and late (3 h) images of the breasts were obtained following the injection of 111 MBq (3 mCi) of TI-201. Visual and semiquantitative interpretation was performed. Results: Final diagnosis confirmed 52 malignant breast lesions and 18 benign conditions. TI-201 visualized 47 of 52 (90%) overall malignant lesions. Thirty-eight of 40 (95%) palpable and 9 of 12 (75%) nonpalpable breast cancers were detected by TI-201 scintigraphy. The smallest mass lesion detected by TI-201 measured 1.5x1.0 cm. Eleven breast lesions were interpreted as indeterminate by mammography and/or sonography. TI-201 scintigraphy excluded malignancy in 7 of 8 (88%) patients with benign breast lesions interpreted as indeterminate. Five of the 18 (28%) benign breast lesions showed TI-201 uptake. None of the fibroadenoma and fibrocystic changes accumulated TI-201. TI-201 scintigraphy, mammography and ultrasonography showed 90%, 92%, 85% overall sensitivity and 72%, 56%, 61% overall specificity respectively. Twenty-one of the 28 (75%) axillary nodal metastatic sites were also detected by TI-201. In malignant and benign lesions, early and late lesion/contralateral normal side (L/N) ratios were 1.58 ± 0.38 (mean ± SD) and 1.48 ± 0.32 (p >0.05), 1.87 ± 0.65 and 1.34 ± 0.20 (p<0.05) respectively. The mean early and late L/N ratios of malignant and benign groups did not show statistical difference (p>0.05). Conclusion: Overall, TI-201 scintigraphy was the most specific of the three methods and yielded favourable results in palpable breast cancers, while it showed lower sensitivity in nonpalpable cancers and axillary metastases. Combined use of TI-201 scintigraphy with mammography and US seems to be useful in difficult cases, such as dense breasts and indeterminate breast lesions.

Amplification of HER-2 Gene in Benign and Malignant Breast Lesions in a Sample of Iraqi Women

2017 ◽  
Vol 13 (2) ◽  
pp. 35-39
Author(s):  
Maysoon Abdul-Ameer Ahmed Al-Salman ◽  
◽  
Risala Hussain Allami ◽  
Lamyaa H. M. Al-Ibrahimi
Keyword(s):  
Breast Lesions ◽  
Malignant Breast ◽  
Iraqi Women ◽  
Her 2

scholarly journals Diffusion tensor imaging on 3-T MRI breast: diagnostic performance in comparison to diffusion-weighted imaging

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Dalia Abdelhady ◽  
Amany Abdelbary ◽  
Ahmed H. Afifi ◽  
Alaa-eldin Abdelhamid ◽  
Hebatallah H. M. Hassan
Keyword(s):  
Breast Cancer ◽  
Diffusion Tensor Imaging ◽  
Sensitivity And Specificity ◽  
Diffusion Weighted Imaging ◽  
Diffusion Tensor ◽  
Breast Mri ◽  
Breast Lesions ◽  
Dce Mri ◽  
Additional Tool ◽  
Diffusion Weighted

Abstract Background Breast cancer is the most prevalent cancer among females. Dynamic contrast-enhanced MRI (DCE-MRI) breast is highly sensitive (90%) in the detection of breast cancer. Despite its high sensitivity in detecting breast cancer, its specificity (72%) is moderate. Owing to 3-T breast MRI which has the advantage of a higher signal to noise ratio and shorter scanning time rather than the 1.5-T MRI, the adding of new techniques as diffusion tensor imaging (DTI) to breast MRI became more feasible. Diffusion-weighted imaging (DWI) which tracks the diffusion of the tissue water molecule as well as providing data about the integrity of the cell membrane has been used as a valuable additional tool of DCE-MRI to increase its specificity. Based on DWI, more details about the microstructure could be detected using diffusion tensor imaging. The DTI applies diffusion in many directions so apparent diffusion coefficient (ADC) will vary according to the measured direction raising its sensitivity to microstructure elements and cellular density. This study aimed to investigate the diagnostic accuracy of DTI in the assessment of breast lesions in comparison to DWI. Results By analyzing the data of the 50 cases (31 malignant cases and 19 benign cases), the sensitivity and specificity of DWI in differentiation between benign and malignant lesions were about 90% and 63% respectively with PPV 90% and NPV 62%, while the DTI showed lower sensitivity and specificity about 81% and 51.7%, respectively, with PPV 78.9% and NPV 54.8% (P-value ≤ 0.05). Conclusion While the DWI is still the most established diffusion parameter, DTI may be helpful in the further characterization of tumor microstructure and differentiation between benign and malignant breast lesions.

Can measuring perilesional tissue stiffness and stiff rim sign improve the diagnostic performance between benign and malignant breast lesions?

2021 ◽  
Vol 48 (1) ◽  
pp. 53-61
Author(s):  
Wen-tao Kong ◽  
Yin Wang ◽  
Wei-jun Zhou ◽  
Yi-dan Zhang ◽  
Wen-ping Wang ◽  
...  
Keyword(s):  
Diagnostic Performance ◽  
Breast Lesions ◽  
Tissue Stiffness ◽  
Malignant Breast

scholarly journals Elastic Modulus and Elasticity Ratio of Malignant Breast Lesions with Shear Wave Ultrasound Elastography: Variations with Different Region of Interest and Lesion Size

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1015
Author(s):  
Antonio Bulum ◽  
Gordana Ivanac ◽  
Eugen Divjak ◽  
Iva Biondić Špoljar ◽  
Martina Džoić Dominković ◽  
...  
Keyword(s):  
Elastic Modulus ◽  
Shear Wave ◽  
Large Diameter ◽  
Small Diameter ◽  
Shear Wave Elastography ◽  
Lesion Size ◽  
Ultrasound Elastography ◽  
Breast Lesions ◽  
Malignant Breast ◽  
The Impact

Shear wave elastography (SWE) is a type of ultrasound elastography with which the elastic properties of breast tissues can be quantitatively assessed. The purpose of this study was to determine the impact of different regions of interest (ROI) and lesion size on the performance of SWE in differentiating malignant breast lesions. The study included 150 female patients with histopathologically confirmed malignant breast lesions. Minimal (Emin), mean (Emean), maximal (Emax) elastic modulus and elasticity ratio (e-ratio) values were measured using a circular ROI size of 2, 4 and 6 mm diameters and the lesions were divided into large (diameter ≥ 15 mm) and small (diameter < 15 mm). Highest Emin, Emean and e-ratio values and lowest variability were observed when using the 2 mm ROI. Emax values did not differ between different ROI sizes. Larger lesions had significantly higher Emean and Emax values, but there was no difference in e-ratio values between lesions of different sizes. In conclusion, when measuring the Emin, Emean and e-ratio of malignant breast lesions using SWE the smallest possible ROI size should be used regardless of lesion size. ROI size has no impact on Emax values while lesion size has no impact on e-ratio values.

scholarly journals Contrast-enhanced ultrasound of breast fibromatosis: a case report

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110106
Author(s):  
Shanhong Lin ◽  
Yong Cao ◽  
Libin Chen ◽  
Mei Chen ◽  
Shengmin Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Rare Case ◽  
Common Type ◽  
Breast Lesions ◽  
Contrast Enhanced Ultrasound ◽  
High Similarity ◽  
Potential Value ◽  
Contrast Enhanced ◽  
Malignant Breast ◽  
Contrast Enhanced Ultrasonography

We herein present a rare case of breast fibromatosis, the contrast-enhanced ultrasonography (CEUS) findings of which we believe have never been described. The high similarity between the clinical and imaging manifestations of breast cancer makes its differential diagnosis difficult. In this report, we describe the CEUS findings of a less common type of fibromatosis, discuss the potential value of CEUS to differentiate it from malignant breast lesions, and briefly review the literature.

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