scholarly journals Serum concentrations of adipocyte fatty acid binding protein in patients with anorexia nervosa

2009 ◽  
pp. 577-581
Author(s):  
D Haluzíková ◽  
I Dostálová ◽  
P Kaválková ◽  
T Roubíček ◽  
M Mráz ◽  
...  

Serum adipocyte fatty acid-binding protein (FABP) concentrations are linked to human obesity and other features of metabolic syndrome. Whether FABP associates with metabolic alterations in chronic malnutrition is unknown. In the present study, we measured fasting serum levels of FABP, leptin, soluble leptin receptor, adiponectin, resistin, C-reactive protein (CRP), insulin, glucose, cholesterol and triglycerides in 19 patients with a restrictive type of anorexia nervosa (AN) and in 16 healthy agematched control women (C). Body mass index, serum leptin, and CRP concentrations were significantly lower, while serum adiponectin and soluble leptin receptor levels were significantly higher in AN relative to C group. Serum insulin, glucose, cholesterol and triglyceride levels did not differ between the groups studied. Serum FABP levels were unchanged in patients with AN and were not related to any of parameters studied. We conclude that, in contrast to patients with obesity where FAPB is a prominent marker of metabolic alterations, chronic malnutrition in AN does not significantly affect its serum levels.

Author(s):  
Renata Mikolášová ◽  
Tomáš Urban

The leptin (LEP-HinfI), leptin receptor (LEPR-HpaII) and heart fatty acid binding protein (H-FABP-HinfI) genes and their genotypes combination (LEP-HinfI *LEPR-HpaII) were tested for associations with the pH1, pH24, myoglobin content (mg/100 g), intramuscular fat content (%) and remission (%). The genotypes were determined in Large White, Landrace and Duroc breeds (n = 106, 56 and 4, respectively). The allele frequencies were: LEP-HinfI: C = 0.133 T = 0.867; LEPR-HpaII: A = 0.331 B = 0.669; H-FABP-HinfI: H = 0.745 h = 0.255. The populations of breeds were in the genetic equilibrium according to the χ2 test in the tested loci. The combinations of LEP-HinfI and LEPR-HpaII were significantly associated with the pH24 and remission. The H-FABP-HinfI locus was significantly associated with intramuscular fat content.


2008 ◽  
Vol 21 (5) ◽  
pp. 582-586 ◽  
Author(s):  
M. Fasshauer ◽  
J. Seeger ◽  
T. Waldeyer ◽  
S. Schrey ◽  
T. Ebert ◽  
...  

Medicine ◽  
2015 ◽  
Vol 94 (41) ◽  
pp. e1798 ◽  
Author(s):  
Fen-Yu Tseng ◽  
Pei-Lung Chen ◽  
Yen-Ting Chen ◽  
Yu-Chao Chi ◽  
Shyang-Ron Shih ◽  
...  

2012 ◽  
Vol 50 (2) ◽  
Author(s):  
Eftihia Sbarouni ◽  
Panagiota Georgiadou ◽  
Maria Koutelou ◽  
Mihas Constantinos ◽  
Antigoni Chaidaroglou ◽  
...  

AbstractHeart-type fatty acid-binding protein (H-FABP) is a marker of myocardial necrosis, but whether it increases during myocardial ischemia is not known. This study investigated whether serum levels of H-FABP change during adenosine stress testing and nuclear imaging in patients with stable coronary artery disease.Thirty stable patients with established coronary artery disease on their medications were studied. Sampling was performed before the stress test, at the end of adenosine infusion, as well as 1, 2 and 3 h after the completion of the infusion.No difference in H-FABP serum levels were found at the five pre-specified time points in the overall group (p=0.99); furthermore, there was no significant difference regardless of the test result – positive (p=1) or negative (p=0.98).It is concluded that H-FABP does not change significantly during pharmacologic stress testing in patients with known coronary artery disease and there is no difference whether there is inducible ischemia or not.


2017 ◽  
Vol 50 (16-17) ◽  
pp. 896-902 ◽  
Author(s):  
Tatsuya Iso ◽  
Hiroaki Sunaga ◽  
Hiroki Matsui ◽  
Shu Kasama ◽  
Naomi Oshima ◽  
...  

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