14-3-3 proteins: a family of versatile molecular regulators
Keyword(s):
The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.
Keyword(s):
1997 ◽
Vol 24
(1)
◽
pp. 45-51
◽
2003 ◽
Vol 23
(14)
◽
pp. 5064-5077
◽
2005 ◽
Vol 7
(5-6)
◽
pp. 752-760
◽
Keyword(s):
2014 ◽
Vol 9
(11)
◽
pp. e972864
◽
Keyword(s):