scholarly journals Kinase Regulation of HOX Transcription Factors

Cancers ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 508 ◽  
Author(s):  
Monika Primon ◽  
Keith D. Hunter ◽  
Hardev S. Pandha ◽  
Richard Morgan
Keyword(s):  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Hox Genes ◽  
Integration Site ◽  
Cell Leukaemia ◽  
Early Event ◽  
Cell Renewal ◽  
Hox Proteins ◽  
Cycle Regulation

The HOX genes are a group of homeodomain-containing transcription factors that play important regulatory roles in early development, including the establishment of cell and tissue identity. HOX expression is generally reduced in adult cells but is frequently re-established as an early event in tumour formation and supports an oncogenic phenotype. HOX transcription factors are also involved in cell cycle regulation and DNA repair, along with normal adult physiological process including stem cell renewal. There have been extensive studies on the mechanism by which HOX proteins regulate transcription, with particular emphasis on their interaction with cofactors such as Pre-B-cell Leukaemia Homeobox (PBX) and Myeloid Ecotropic Viral Integration Site 1 (MEIS). However, significantly less is known of how the activity of HOX proteins is regulated. There is growing evidence that phosphorylation may play an important role in this context, and in this review, we draw together a number of important studies published over the last 20 years, and discuss the relevance of phosphorylation in the regulation and function of HOX proteins in development, evolution, cell cycle regulation, and cancer.

scholarly journals G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1

2003 ◽  
Vol 23 (14) ◽  
pp. 5064-5077 ◽  
Author(s):  
Michael Costanzo ◽  
Oliver Schub ◽  
Brenda Andrews
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Cycle ◽  
Transcription Factors ◽  
Transcriptional Activation ◽  
Chromatin Immunoprecipitation ◽  
Cell Cycle Regulation ◽  
Binding Protein ◽  
Microarray Studies ◽  
Cycle Regulation ◽  
Integral Feature

ABSTRACT Stage-specific transcriptional programs are an integral feature of cell cycle regulation. In the budding yeast Saccharomyces cerevisiae, over 120 genes are coordinately induced in late G1 phase by two heterodimeric transcription factors called SBF and MBF. Activation of SBF and MBF is an upstream initiator of key cell cycle events, including budding and DNA replication. SBF and MBF regulation is complex and genetically redundant, and the precise mechanism of G1 transcriptional activation is unclear. Assays using SBF- and MBF-specific reporter genes revealed that the STB1 gene specifically affected MBF-dependent transcription. STB1 encodes a known Swi6-binding protein, but an MBF-specific function had not been previously suspected. Consistent with a specific role in regulating MBF, a STB1 deletion strain requires SBF for viability and microarray studies show a decrease in MBF-regulated transcripts in a swi4Δ mutant following depletion of Stb1. Chromatin immunoprecipitation experiments confirm that Stb1 localizes to promoters of MBF-regulated genes. Our data indicate that, contrary to previous models, MBF and SBF have unique components and might be distinctly regulated.

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Nature ◽  
2000 ◽  
Vol 404 (6779) ◽  
pp. 782-787 ◽  
Author(s):  
René H. Medema ◽  
Geert J. P. L. Kops ◽  
Johannes L. Bos ◽  
Boudewijn M. T. Burgering
Keyword(s):  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Forkhead Transcription Factors ◽  
Mediate Cell ◽  
Cycle Regulation

scholarly journals 14-3-3 proteins: a family of versatile molecular regulators

2008 ◽  
pp. S11-S21
Author(s):  
V Obšilová ◽  
J Šilhan ◽  
E Bouřa ◽  
J Teisinger ◽  
T Obšil
Keyword(s):  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Molecular Scaffolds ◽  
Forkhead Transcription Factors ◽  
Binding Partners ◽  
Wide Range ◽  
Functional Modulation ◽  
Cycle Regulation ◽  
And Control

The 14-3-3 proteins are a family of acidic regulatory molecules found in all eukaryotes. 14-3-3 proteins function as molecular scaffolds by modulating the conformation of their binding partners. Through the functional modulation of a wide range of binding partners, 14-3-3 proteins are involved in many processes, including cell cycle regulation, metabolism control, apoptosis, and control of gene transcription. This minireview includes a short overview of 14-3-3 proteins and then focuses on their role in the regulation of two important binding partners: FOXO forkhead transcription factors and an enzyme tyrosine hydroxylase.

FOXO Transcription Factors in Cell-Cycle Regulation and the Response to Oxidative Stress

2005 ◽  
Vol 7 (5-6) ◽  
pp. 752-760 ◽  
Author(s):  
Yoko Furukawa-Hibi ◽  
Yosuke Kobayashi ◽  
Chen Chen ◽  
Noboru Motoyama
Keyword(s):  
Oxidative Stress ◽  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Cycle Regulation ◽  
Foxo Transcription Factors ◽  
Cycle Regulation

scholarly journals Cell Cycle Regulation by Heat Shock Transcription Factors

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 203
Author(s):  
Yasuko Tokunaga ◽  
Ken-Ichiro Otsuyama ◽  
Naoki Hayashida
Keyword(s):  
Cell Cycle ◽  
Transcription Factors ◽  
Cell Division ◽  
Heat Shock ◽  
Cell Cycle Regulation ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Heat Shock Transcription Factors ◽  
Gene Bookmarking ◽  
Cycle Regulation

Cell division and cell cycle mechanism has been studied for 70 years. This research has revealed that the cell cycle is regulated by many factors, including cyclins and cyclin-dependent kinases (CDKs). Heat shock transcription factors (HSFs) have been noted as critical proteins for cell survival against various stresses; however, recent studies suggest that HSFs also have important roles in cell cycle regulation-independent cell-protective functions. During cell cycle progression, HSF1, and HSF2 bind to condensed chromatin to provide immediate precise gene expression after cell division. This review focuses on the function of these HSFs in cell cycle progression, cell cycle arrest, gene bookmarking, mitosis and meiosis.

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