scholarly journals AN EXPERIMENTAL STUDY OF A NOVEL DOMESTIC VITREOUS SUBSTITUTE “VITREOLON” IN COMPARISON WITH SILICONE OIL IN SIMULATED RETINAL DETACHMENT IN RABBITS

Biomeditsina ◽  
2019 ◽  
pp. 78-89
Author(s):  
I. B. Alekseyev ◽  
A. R. Korigodskiy ◽  
E. N. Iomdina ◽  
A. A. Fedorov ◽  
V. E. Belkin ◽  
...  
Keyword(s):  
Experimental Study ◽  
Retinal Detachment ◽  
Silicone Oil ◽  
Physiological State ◽  
Vitreous Body ◽  
Ophthalmic Surgery ◽  
Experimental Animals ◽  
Clinical Conditions ◽  
Observation Period

This article presents the results of an experimental study of a new domestic preparation “Vitreolon”, an artifi cial vitreous body based on a weakly cross-linked hydrogel. The safety and effi cacy of this product for the treatment of retinal detachment in experimental animals was evaluated in comparison with silicone oil. The tamponade properties of each drug, their effect on the internal structure of the animal’s eye, convenience and safety of use in ophthalmic surgery were investigated. A base for conducting detailed preclinical and clinical trials was prepared.Rabbits of the gray chinchilla breed were chosen for the study, largely because the size of their eye is close to that of the human eye. This fact allowed us to study the effect of “Vitreolon” in an amount approximately equal to that used in clinical conditions. During the experiment, the indicators of ophthalmological examinations of experimental animals were recorded. The physiological state of the animals was controlled daily. The observation period ranged from 3 months (for rabbits with a silicone tamponade) to 6 months (for rabbits with a tamponade using the new hydrogel artificial vitreous body).It is found that “Vitreolon” is not inferior to silicone oil in terms of tamponade properties. Moreover, it boasts a number of signifi cant advantages, such as a lack of emulsifi cation, absence of migration to the anterior chamber of the eye, no effect on the exchange of intraocular fl uid, no effect on the intraocular pressure (IOP), long-term retention of the shape and transparency. The characteristics of the new hydrogel artifi cial vitreous body are close to those of the native vitreous body. The application of “Vitreolon” in ophthalmic surgery will increase the effi cacy of retinal detachment treatment by reducing the recovery time.

Biomedical Materials to Repair Retinal Detachments

1985 ◽  
Vol 55 ◽  
Author(s):  
Miguel F. Refojo
Keyword(s):  
Retinal Detachment ◽  
Silicone Rubber ◽  
Methyl Acrylate ◽  
Silicone Oil ◽  
Vitreous Body ◽  
Light Sensitivity ◽  
Scleral Buckling ◽  
Intraocular Injection ◽  
Other Substances

ABSTRACTImplants are essential for the repair of retinal detachments. The implant buckles the wall of the eye and apposes the detached retina with the choroid, thus restoring light sensitivity to the retina. The scleral buckling also relieves traction on the retina from a shrinking vitreous body. The implant materials most commonly used are solid silicone rubber and silicone sponges, but both types have some disadvantages. A poly(hydroxyethyl acrylate-co-methyl acrylate) hydrogel implant with improved properties of softness and antibiotic absorption is also available for retinal detachment surgery. Proliferative vitreoretinopathy involves various conditions of retinal detachment complicated by vitreous fibrosis, which, after vitrectomy, may be treated with intraocular injection of fluids that support the retina against the choroid. For conditions requiring a long-term implant, silicone oil although controversial is the material of choice. Many other substances have been investigated but none better has yet been found.

scholarly journals Foldable capsular vitreous body implantation for treatment of traumatic retinal detachment: two case reports

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052199025
Author(s):  
Baihui Zeng ◽  
Qian Wang ◽  
Guiqin Sui ◽  
Mingxuan Wang ◽  
Wei Xie ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Large Scale ◽  
Silicone Oil ◽  
Case Reports ◽  
Vitreous Body ◽  
Clinical Applications ◽  
Current Evidence ◽  
Vitreoretinal Disease ◽  
Silicone Oil Tamponade

Retinal detachment caused by severe ocular trauma is a type of refractory vitreoretinal disease. Current treatment methods include vitrectomy combined with silicone oil tamponade. However, long-term use of silicone oil tamponade has various complications, including a risk of silicone oil dependence that eventually leads to eyeball atrophy and enucleation. Foldable capsular vitreous bodies (FCVBs) offer a good solution for these problems. However, FCVBs have not been used in large-scale clinical applications and few cases have been reported in the published literature. The main use of FCVBs, based on current evidence, is in the treatment of the relatively few (but important) patients whose eyes have no visual potential; the aim of treatment in these patients is globe preservation, rather than restoration of vision. Here, we describe two patients who underwent FCVB implantation. The findings in these patients indicated that FCVBs can effectively support the vitreous cavity and detached retina. FCVB implantation may thus offer a safe and effective method for treatment of severe retinal detachment, avoiding the inconvenience caused by silicone oil dependence and enucleation. To confirm its long-term usefulness in clinical applications, many additional case reports are needed.

scholarly journals Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment

2016 ◽  
Vol 5 (1) ◽  
pp. 2 ◽  
Author(s):  
Xiaofeng Lin ◽  
Xuyuan Sun ◽  
Zhenfang Wang ◽  
Zhaoxin Jiang ◽  
Yaqin Liu ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Silicone Oil ◽  
Vitreous Body ◽  
Efficacy And Safety

scholarly journals Novel Suturing Methods for the Management of Traumatic Choroidal Avulsion in Globe Injuries

2022 ◽  
Vol 8 ◽  
Author(s):  
Huijin Chen ◽  
Jiarui Yang ◽  
Changguan Wang ◽  
Xuefeng Feng ◽  
Kang Feng ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Silicone Oil ◽  
Open Globe Injury ◽  
Oil Migration ◽  
Corrected Visual Acuity ◽  
Open Globe ◽  
Baseline Information ◽  
Suturing Methods

PurposeTo explore the long-term efficacy of novel choroidal suturing methods including trans-scleral mattress suturing (TSS) and intraocular suturing (IOS) in the treatment of choroidal avulsion.DesignProspective cohort, hospital-based study.MethodsA total of 24 patients who were diagnosed with choroidal avulsion were enrolled in this study. The demographic characteristics, baseline information of trauma, best-corrected visual acuity (BCVA), and intraocular pressure (IOP) were collected before surgery, and the anatomic abnormities of the globe were recorded before or during surgery. All patients were diagnosed with choroidal avulsion and underwent choroid suturing treatment during vitrectomy, postoperative functional variables including BCVA and IOP, anatomic variables including retinal and choroidal reattachment rate, and silicone oil migration rate, which were recorded at the regular follow-ups at least 1 year after surgery.ResultsAll patients with open globe injury involved zone III, 70.8% of the patients presented with two quadrants of the avulsed choroid, and 29.2% with one quadrant involved; moreover, all patients had complications with retinal detachment (RD), of which 58.3% of patients had closed funnel retinal detachment. TSS was applied in nineteen patients and IOS in five patients. Postoperatively, a significant improvement on LogMAR BCVA was observed at each follow-up from 3.57 ± 0.69 before surgery to 2.82 ± 0.98 at the last follow-up (p < 0.05), and the proportion of no light perception (NLP) was also reduced from 69.6 to 37.5%. IOP was markedly elevated from 6.4 ± 4.1 mmHg preoperatively to 11.3 ± 4.3 mmHg at the last follow-up (p < 0.05). Choroidal reattachment was achieved in 91.7% of patients; two patients were observed with silicone oil migration at 3 months after surgery and underwent drainage of suprachoroidal silicone oil and sclera buckling. Meanwhile, retinal attachment was observed in 95.8% of patients, only one patient developed partial RD due to postoperative proliferative vitreoretinopathy, and secondary vitrectomy was performed; all patients were observed with complete retinal and choroidal attachment at the last follow-up. Eventually, four patients were silicone oil-free, and 20 patients were silicone oil-dependent.ConclusionsChoroidal suturing proved to be an effective method to fix the avulsed choroid, which greatly improved the BCVA and maintained the IOP, and efficiently increased the choroidal and retinal reattachment rate and preservation of the eyeball.

scholarly journals Preliminary Study on Retinal Vascular and Oxygen-related Changes after Long-term Silicone Oil and Foldable Capsular Vitreous Body Tamponade

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Wei Yang ◽  
Yongguang Yuan ◽  
Yao Zong ◽  
Zhen Huang ◽  
Shuyi Mai ◽  
...  
Keyword(s):  
Silicone Oil ◽  
Vitreous Body ◽  
Preliminary Study

scholarly journals Unrecognized Orbital Images Cause Diagnostic Confusion: Silicone Oil and Implanted Silicone Encircling Bands

2021 ◽  
Vol 2021 ◽  
pp. 1-3
Author(s):  
Tsuyoshi Nojima ◽  
Takafumi Obara ◽  
Kohei Tsukahara ◽  
Atsunori Nakao ◽  
Hiromichi Naito
Keyword(s):  
Case Report ◽  
Retinal Detachment ◽  
Head Trauma ◽  
Silicone Oil ◽  
Ophthalmological Examination ◽  
Ophthalmic Surgery ◽  
High Attenuation ◽  
Postoperative Changes ◽  
Imaging Characteristics ◽  
Diagnostic Confusion

Introduction. Most physicians are not familiar with postoperative changes to the orbit, so radiologists and clinicians may sometimes find it challenging to conduct a proper radiological assessment of the globe of the eye and orbital abnormalities. We present a patient with head trauma who had surgery for retinal detachment with implantation of silicone encircling bands. This case report may help clinicians recognize imaging characteristics after ophthalmic surgery to prevent misdiagnosis and unnecessary workup. Case Report. An 18-year-old man with severe head trauma was admitted to our hospital. Initial computed tomography (CT) revealed a high attenuation of intraocular silicone that could be mistaken for a hemorrhage. Ophthalmological examination and detailed ophthalmic history confirmed silicone oil in his eye for treatment of retinal detachment. Knowledge of the anatomical changes and radiological appearance of postsurgical findings following retinal detachment, including the surgical materials of silicone oil or bands, can prevent unnecessary alarm. Conclusion. Implanted ophthalmic devices, for example, silicone oil, appear similar to hemorrhages on CT and magnetic resonance imaging and cause diagnostic confusion. When in doubt, it is useful to assess the clinical presentation and obtain an accurate medical history.

scholarly journals Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiangyang Zhang ◽  
Xuemin Tian ◽  
Baike Zhang ◽  
Lisa Guo ◽  
Xiaodan Li ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Ocular Trauma ◽  
Silicone Oil ◽  
Vitreous Body ◽  
Fundus Photography ◽  
Specular Microscopy ◽  
Applanation Tonometer ◽  
Before And After ◽  
Fellow Eyes

Abstract Background Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1-year follow-up. Methods A retrospective analysis was conducted for 20 patients with severe ocular trauma or silicone oil (SO) dependent eyes underwent vitrectomy and FCVB implantation in a 1-year follow-up. All treated eyes were peformed clinical examinations involved the visual acuity (VA) examination, Goldmann applanation tonometer, noncontact specular microscopy, fundus photography, B-Scan examination and optical coherence tomography (OCT). The groups were compared with t-test and the McNemar - Bowker test. Results In 1-year follow-up, 20 eyes were evaluated in the study. FCVB well supported the vitreous retina in all treated eyes, and 6 treated eyes achieved retinal reattachment 12 months after FCVB implantation. There were no significant differences in VA before and after FCVB implantation (P = 1.000). In addition, the postoperative IOP markedly elevated from the preoperative IOP of 12.90 ± 7.06 mmHg to 15.15 ± 3.36 mmHg (P = 0.000017). The intraocular pressure (IOP) of 10 eyes maintained at a normal level after surgeries. The other 10 eyes showed slightly lower IOP within the acceptable level. Though two patients developed keratopathy and ocular inflammation respectively, other treated eyes were symmetric with fellow eyes showing satisfactory appearance. Moreover, there was no SO emulsification or leakage happened in the observation. Conclusions FCVB implantation was an effective and safe treatment in the eyes with severe retinal detachment.

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