Three-Year Efficacy and Safety of a Silicone Oil-Filled Foldable-Capsular-Vitreous-Body in Three Cases of Severe Retinal Detachment

ABSTRACTImplants are essential for the repair of retinal detachments. The implant buckles the wall of the eye and apposes the detached retina with the choroid, thus restoring light sensitivity to the retina. The scleral buckling also relieves traction on the retina from a shrinking vitreous body. The implant materials most commonly used are solid silicone rubber and silicone sponges, but both types have some disadvantages. A poly(hydroxyethyl acrylate-co-methyl acrylate) hydrogel implant with improved properties of softness and antibiotic absorption is also available for retinal detachment surgery. Proliferative vitreoretinopathy involves various conditions of retinal detachment complicated by vitreous fibrosis, which, after vitrectomy, may be treated with intraocular injection of fluids that support the retina against the choroid. For conditions requiring a long-term implant, silicone oil although controversial is the material of choice. Many other substances have been investigated but none better has yet been found.

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Evaluation of the Flexibility, Efficacy, and Safety of a Foldable Capsular Vitreous Body in the Treatment of Severe Retinal Detachment

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.10-5869 ◽

2011 ◽

Vol 52 (1) ◽

pp. 374 ◽

Cited By ~ 21

Author(s):

Xiaofeng Lin ◽

Jian Ge ◽

Qianying Gao ◽

Zhenfang Wang ◽

Chongde Long ◽

...

Keyword(s):

Retinal Detachment ◽

Vitreous Body ◽

Efficacy And Safety

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Efficacy and safety of heavy silicone oil Densiron 68® in the treatment of complicated retinal detachment with large inferior retinectomy

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-008-0876-6 ◽

2008 ◽

Vol 246 (10) ◽

pp. 1383-1389 ◽

Cited By ~ 26

Author(s):

Sylvain Auriol ◽

Véronique Pagot-Mathis ◽

Laurence Mahieu ◽

Claudia Lemoine ◽

André Mathis

Keyword(s):

Retinal Detachment ◽

Silicone Oil ◽

Efficacy And Safety ◽

Heavy Silicone Oil

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Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

BMC Ophthalmology ◽

10.1186/s12886-019-1268-x ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 3

Author(s):

Xiangyang Zhang ◽

Xuemin Tian ◽

Baike Zhang ◽

Lisa Guo ◽

Xiaodan Li ◽

...

Keyword(s):

Retinal Detachment ◽

Ocular Trauma ◽

Silicone Oil ◽

Vitreous Body ◽

Fundus Photography ◽

Specular Microscopy ◽

Applanation Tonometer ◽

Before And After ◽

Fellow Eyes

Abstract Background Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1-year follow-up. Methods A retrospective analysis was conducted for 20 patients with severe ocular trauma or silicone oil (SO) dependent eyes underwent vitrectomy and FCVB implantation in a 1-year follow-up. All treated eyes were peformed clinical examinations involved the visual acuity (VA) examination, Goldmann applanation tonometer, noncontact specular microscopy, fundus photography, B-Scan examination and optical coherence tomography (OCT). The groups were compared with t-test and the McNemar - Bowker test. Results In 1-year follow-up, 20 eyes were evaluated in the study. FCVB well supported the vitreous retina in all treated eyes, and 6 treated eyes achieved retinal reattachment 12 months after FCVB implantation. There were no significant differences in VA before and after FCVB implantation (P = 1.000). In addition, the postoperative IOP markedly elevated from the preoperative IOP of 12.90 ± 7.06 mmHg to 15.15 ± 3.36 mmHg (P = 0.000017). The intraocular pressure (IOP) of 10 eyes maintained at a normal level after surgeries. The other 10 eyes showed slightly lower IOP within the acceptable level. Though two patients developed keratopathy and ocular inflammation respectively, other treated eyes were symmetric with fellow eyes showing satisfactory appearance. Moreover, there was no SO emulsification or leakage happened in the observation. Conclusions FCVB implantation was an effective and safe treatment in the eyes with severe retinal detachment.

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Study On the Effectiveness and Safety of Foldable Capsular Vitreous Body Implantation

10.21203/rs.2.233/v3 ◽

2019 ◽

Author(s):

Xiangyang Zhang ◽

Xuemin Tian ◽

Baike Zhang ◽

Lisa Guo ◽

Xiaodan Li ◽

...

Keyword(s):

Retinal Detachment ◽

Silicone Oil ◽

Vitreous Body ◽

Fundus Photography ◽

Specular Microscopy ◽

Test Results ◽

Applanation Tonometer ◽

Before And After ◽

Fellow Eyes

Abstract Background: Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1-year follow-up. Methods: A retrospective analysis was conducted for 20 patients with severe ocular trauma or silicone oil (SO) dependent eyes underwent vitrectomy and FCVB implantation in a 1-year follow-up. All treated eyes were peformed clinical examinations involved the visual acuity (VA) examination, Goldmann applanation tonometer, noncontact specular microscopy, fundus photography, B-Scan examination and optical coherence tomography (OCT). The groups were compared with t-test and the McNemar - Bowker test. Results: In 1-year follow-up, 20 eyes were evaluated in the study. FCVB well supported the vitreous retina in all treated eyes, and 6 treated eyes achieved retinal reattachment 12 months after FCVB implantation. There were no significant differences in VA before and after FCVB implantation (P = 1.000). In addition, the postoperative IOP markedly elevated from the preoperative IOP of 12.90 ± 7.06 mmHg to 15.15 ± 3.36 mmHg (P = 0.000017). The intraocular pressure (IOP) of 10 eyes maintained at a normal level after surgeries. The other 10 eyes showed slightly lower IOP within the acceptable level. Though two patients developed keratopathy and ocular inflammation respectively, other treated eyes were symmetric with fellow eyes showing satisfactory appearance. Moreover, there was no SO emulsification or leakage happened in the observation.Conclusions: FCVB implantation was an effective and safe treatment in the eyes with severe retinal detachment. Keywords: Foldable Capsular Vitreous Body; Efficacy; Safety; Retinal detachment

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AN EXPERIMENTAL STUDY OF A NOVEL DOMESTIC VITREOUS SUBSTITUTE “VITREOLON” IN COMPARISON WITH SILICONE OIL IN SIMULATED RETINAL DETACHMENT IN RABBITS

Biomeditsina ◽

10.33647/2074-5982-15-3-78-89 ◽

2019 ◽

pp. 78-89

Author(s):

I. B. Alekseyev ◽

A. R. Korigodskiy ◽

E. N. Iomdina ◽

A. A. Fedorov ◽

V. E. Belkin ◽

...

Keyword(s):

Experimental Study ◽

Retinal Detachment ◽

Silicone Oil ◽

Physiological State ◽

Vitreous Body ◽

Ophthalmic Surgery ◽

Experimental Animals ◽

Clinical Conditions ◽

Observation Period

This article presents the results of an experimental study of a new domestic preparation “Vitreolon”, an artifi cial vitreous body based on a weakly cross-linked hydrogel. The safety and effi cacy of this product for the treatment of retinal detachment in experimental animals was evaluated in comparison with silicone oil. The tamponade properties of each drug, their effect on the internal structure of the animal’s eye, convenience and safety of use in ophthalmic surgery were investigated. A base for conducting detailed preclinical and clinical trials was prepared.Rabbits of the gray chinchilla breed were chosen for the study, largely because the size of their eye is close to that of the human eye. This fact allowed us to study the effect of “Vitreolon” in an amount approximately equal to that used in clinical conditions. During the experiment, the indicators of ophthalmological examinations of experimental animals were recorded. The physiological state of the animals was controlled daily. The observation period ranged from 3 months (for rabbits with a silicone tamponade) to 6 months (for rabbits with a tamponade using the new hydrogel artificial vitreous body).It is found that “Vitreolon” is not inferior to silicone oil in terms of tamponade properties. Moreover, it boasts a number of signifi cant advantages, such as a lack of emulsifi cation, absence of migration to the anterior chamber of the eye, no effect on the exchange of intraocular fl uid, no effect on the intraocular pressure (IOP), long-term retention of the shape and transparency. The characteristics of the new hydrogel artifi cial vitreous body are close to those of the native vitreous body. The application of “Vitreolon” in ophthalmic surgery will increase the effi cacy of retinal detachment treatment by reducing the recovery time.

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Foldable capsular vitreous body implantation for treatment of traumatic retinal detachment: two case reports

Journal of International Medical Research ◽

10.1177/0300060521990257 ◽

2021 ◽

Vol 49 (2) ◽

pp. 030006052199025

Author(s):

Baihui Zeng ◽

Qian Wang ◽

Guiqin Sui ◽

Mingxuan Wang ◽

Wei Xie ◽

...

Keyword(s):

Retinal Detachment ◽

Large Scale ◽

Silicone Oil ◽

Case Reports ◽

Vitreous Body ◽

Clinical Applications ◽

Current Evidence ◽

Vitreoretinal Disease ◽

Silicone Oil Tamponade

Retinal detachment caused by severe ocular trauma is a type of refractory vitreoretinal disease. Current treatment methods include vitrectomy combined with silicone oil tamponade. However, long-term use of silicone oil tamponade has various complications, including a risk of silicone oil dependence that eventually leads to eyeball atrophy and enucleation. Foldable capsular vitreous bodies (FCVBs) offer a good solution for these problems. However, FCVBs have not been used in large-scale clinical applications and few cases have been reported in the published literature. The main use of FCVBs, based on current evidence, is in the treatment of the relatively few (but important) patients whose eyes have no visual potential; the aim of treatment in these patients is globe preservation, rather than restoration of vision. Here, we describe two patients who underwent FCVB implantation. The findings in these patients indicated that FCVBs can effectively support the vitreous cavity and detached retina. FCVB implantation may thus offer a safe and effective method for treatment of severe retinal detachment, avoiding the inconvenience caused by silicone oil dependence and enucleation. To confirm its long-term usefulness in clinical applications, many additional case reports are needed.

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Extrascleral Filling Using Endoillumination the First Experiencethe

Russian ophthalmology of children ◽

10.25276/2307-6658-2020-3-43-49 ◽

2020 ◽

pp. 43-49

Author(s):

V.Y. Markevich ◽

◽

T.A. Imshenetskaya ◽

O.A. Yarmak ◽

◽

...

Keyword(s):

Surgical Treatment ◽

Retinal Detachment ◽

Rhegmatogenous Retinal Detachment ◽

Silicone Oil ◽

Subretinal Fluid ◽

Crystalline Lens ◽

Vitreous Cavity ◽

Macular Area ◽

General Group ◽

Anatomical Outcome

Purpose. To study the effectiveness of extrascleral filling (ESF) using endoillumination in the surgical treatment of patients with primary rhegmatogenous retinal detachment (RRD). Material and methods. The material for the study was the data of a comprehensive clinical examination and surgical treatment by ESF method using endoillumination in 17 patients (17 eyes) with RRD. In 7 cases (41%), the macular area was involved in the detachment process. In 5 cases (29.4%), local scleral filling was performed. In the remaining 12 cases (70.6%), the local ESF was supplemented with a circling silicone element. Surgical intervention was supplemented by transscleral drainage of subretinal fluid (SRF) in 10 cases (59%) and pneumatic retinopexy with SF6 gas 50% in 8 cases (48%). Results. In the general group of patients, best corrected visual acuity (BCVA) increased from 0.35 to 0.46. In the subgroup of patients with a detached macular area, the positive dynamics is more pronounced, BCVA increased from 0.1 to 0.28. The progression of proliferative vitreoretinopathy caused the recurrence of retinal detachment in two patients (11.8%). Recurrences were diagnosed after 3 and 5 months, respectively. In both cases, a vitrectomy with tamponade of the vitreous cavity with silicone oil 5000 Cst was performed. The percentage of successful anatomical outcome after the first operation in our study was 82%. The percentage of successful achievement of the final anatomical result was 94%. In two cases, additional injection of SF6 gas into the vitreous cavity was required. Conclusion. This type of surgical treatment is an effective method of surgical treatment of patients with RRD. In our study, the successful anatomical outcome after the first operation was recorded in 82% of patients, which correlates with the data of the authors who also used this method (83–92%). Surgeons who performed surgical treatment using this technique in our study note improved workplace ergonomics when visualizing the fundus using an operating microscope and endoillumination compared with indirect ophthalmoscopy. Other teams of authors came to this conclusion as well. In our study, there were no complications associated with the introduction of a light pipe into the vitreous cavity (iatrogenic crystalline lens injury, endophthalmitis), which indicates the safety of this type of surgical treatment.

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Refractory Myopic Retinal Detachment and Macular Hole Closure with Autologous Neurosensory Retinal Free Flap

Case Reports in Ophthalmology ◽

10.1159/000500275 ◽

2019 ◽

Vol 10 (2) ◽

pp. 160-164 ◽

Cited By ~ 1

Author(s):

Filipe Sousa Neves ◽

Joana Braga ◽

Paula Sepúlveda ◽

Miguel Bilhoto

Keyword(s):

Retinal Detachment ◽

Macular Hole ◽

Free Flap ◽

Vision Loss ◽

Silicone Oil ◽

Modified Technique ◽

Alternative Approach ◽

Retinal Atrophy ◽

One Year ◽

Hole Closure

The purpose of this case report is to describe a modified technique involving the use of an autologous neurosensory retinal free flap for closure of a macular hole (MH) during retinal detachment (RD) surgery. A 50-year-old female presented with sudden vision loss (light perception only) and a recurrent myopic RD associated with an MH. An autologous neurosensory retinal free flap was obtained and moved toward the MH. Silicone oil was used as an endotamponade and removed after 6 months. Two months after oil removal visual acuity improved to 20/400 and remained stable thereafter; however, the patient developed central retinal atrophy. One year after surgery the MH was closed and the retina attached. This modified technique with the use of an autologous neurosensory retinal flap provides an alternative approach for recurrent MH in RD procedures.

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