Hashimoto‘s thyroiditis

2021 ◽  
Vol 100 (3) ◽  
Keyword(s):  
Autoimmune Disease ◽  
Thyroid Gland ◽  
Malignant Tumor ◽  
Lymphocytic Infiltration ◽  
Conservative Surgery ◽  
Hashimoto Thyroiditis ◽  
Mechanical Compression ◽  
Iodine Supplementation ◽  
Large Goiter ◽  
Organ Specific

Hashimoto thyroiditis is a chronic organ-specific autoimmune disease. It is characterized by the production of autoantibodies against thyroid gland antigens with lymphocytic infiltration of the gland, leading to gradual destruction of a functional parenchyma. The disease is a leading cause of hypothyreosis in the areas with sufficient iodine supplementation. Etiology is currently unknown, occurence of other autoimmune diseases is common and familiar occurence was noted. The disease is associated with higher risk of thyroid gland malignancy. The treatment is usually conservative, surgery is indicated in suspicion for malignant tumor or in cases of a large goiter with mechanical compression.

scholarly journals Autoimmune thyroid disease and associated autoimmunity

2005 ◽  
Vol 133 (Suppl. 1) ◽  
pp. 16-24 ◽  
Author(s):  
Snezana Djurica ◽  
Bozo Trbojevic ◽  
Dragoslav Milosevic ◽  
Natasa Markovic
Keyword(s):  
Autoimmune Disease ◽  
Thyroid Gland ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Lymphoid Cells ◽  
Initial Report ◽  
Endocrine Orbitopathy ◽  
Autoimmune Thyroid ◽  
Autoimmune Attack ◽  
Organ Specific

Autoimmune diseases are manifested in a broad spectrum. Classic examples of organ-specific autoimmune disease include Addison?s disease, insulin-dependent type-1 Diabetes mellitus, Grave?s disease (MGB), and Hashimoto thyroiditis (HT). The initial report of this autoimmune thyroid disease (AITD) dates back to Hakira Hashimoto (1912). In HT, as an organ-specific autoimmune disease, massive infiltration of lymphoid cells and parenchyma destruction are a consistent feature. The infiltration appears to be immune-mediated, primarily lymphocytic (T helper, T suppressor cells), NK cells and B cells. The pathological characteristics of AITD include development of the goitre (atrophic form is not so frequent), impaired thyroid gland function (from hyperthyroidism to subclinical and manifested hypothyroidism) and the formation of antithyroidal antibodies against thyroglobulin (AbTg) and the microsomal antigen (Ab TPO). There is a very good correlation between the antibodies against TPO and the histological findings. Morbus Graves Basedow is characterized by autoimmune hyperthyroidism with goitre, and infiltrative orbitopathy. Autoantibodies against the TSH-receptor molecule on the plasma membrane of the thyroid gland follicles cause a nonphysiological activation and an increase of the cellular function. Besides this hyperthyroidal condition, an autoimmune attack against the retrobulbar tissue leading to endocrine orbitopathy, can be noted in about 40% of patients suffering from MGB.

scholarly journals Coexistence of sarcoidosis and Hashimoto thyroiditis

Reumatismo ◽  
2018 ◽  
Vol 70 (2) ◽  
pp. 106
Author(s):  
H. Semiz ◽  
M. Yalcin ◽  
S. Kobak
Keyword(s):  
Thyroid Gland ◽  
Hashimoto Thyroiditis ◽  
Skin Lesions ◽  
Chronic Inflammatory Disease ◽  
Endocrine Glands ◽  
Locomotor System ◽  
Caseating Granuloma ◽  
Bilateral Hilar Lymphadenopathy ◽  
Organ Specific ◽  
Eye Involvement

Sarcoidosis is a chronic, inflammatory disease with unknown cause characterized by non-caseating granuloma formations. It can present with bilateral hilar lymphadenopathy, skin lesions, eye involvement and locomotor system findings. Hashimoto thyroiditis is an organ-specific autoimmune disease characterized by increased autoantibody synthesis. Sarcoidosis can involve different endocrine glands. Thyroid gland involvement may lead to increased thyroid function disorders and autoantibodies. Herein, we report an 80-year-old female patient with sarcoidosis and Hashimoto coexistence.

scholarly journals Sarcoidosis following alemtuzumab treatment for multiple sclerosis

2018 ◽  
Vol 24 (13) ◽  
pp. 1779-1782 ◽  
Author(s):  
Mark D Willis ◽  
Ben Hope-Gill ◽  
Patrick Flood-Page ◽  
Fady Joseph ◽  
Ed Needham ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Disease ◽  
Thyroid Gland ◽  
Inflammatory Disease ◽  
Therapeutic Agent ◽  
Case Series ◽  
Retrospective Case ◽  
Proven Efficacy ◽  
Organ Specific ◽  
Auto Inflammatory Disease

Despite proven efficacy of alemtuzumab in multiple sclerosis (MS), approximately 50% of individuals will develop a new autoimmune disease following treatment. To date, these have largely been antibody mediated and organ specific (primarily affecting the thyroid gland). In a retrospective case series of 187 patients from two UK specialist centres (Cardiff and Cambridge) followed up for a median of 10 years, we report three (1.6%) cases of sarcoidosis following alemtuzumab treatment of MS. This report increases the spectrum of auto-inflammatory disease following alemtuzumab and should be considered by clinicians when using this therapeutic agent for MS.

scholarly journals HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mingkun Chen ◽  
Li Zhu ◽  
Miao Xue ◽  
Rongrong Zhu ◽  
Liling Jing ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Autoimmune Disease ◽  
Serum Concentration ◽  
Malignant Tumor ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Healthy Control Group ◽  
Control Group ◽  
Elisa Kit ◽  
Healthy Control

AbstractTo evaluate the feasibility of serum HMGB1, anti-HMGB1 antibodies, and HMGB1/anti-HMGB1 ratio as a diagnosis indicator of initial clinical classification in patients with fever of unknown origin (FUO). Ninety-four patients with classical FUO and ninety healthy controls were enrolled in this study. The subjects’ clinical data and serum were collected. The serum concentration of HMGB1 was detected by a commercial HMGB1 ELISA kit, while the serum concentration of anti-HMGB1 antibodies were detected by an in-house built anti-HMGB1 antibodies ELISA kit and further confirmed by immunoblotting. According to the hospital diagnosis on discharge, ninety-four FUO patients were divided into four groups, Infectious disease subgroup, autoimmune disease subgroup, malignant tumor subgroup, and undetermined subgroup. The concentrations of HMGB1 in the infectious disease subgroup and autoimmune disease subgroup were higher than those in the malignant tumor subgroup, undetermined subgroup, and healthy control group. The concentration of anti-HMGB1 antibodies in autoimmune disease subtype group was higher than those in other subgroups as well as healthy control group. According to the distribution of HMGB1 and anti-HMGB1 in scatter plots of the patients with FUO, we found that the ratio of serum HMGB1/anti-HMGB1 is an ideal clinical indicator for differential diagnosis of different subtypes of FUO. The best cut-off was 0.75, and the sensitivity, specificity, and AUC were 66.67%, 87.32%, and 0.8, respectively. Correlation analysis showed that serum concentration of HMGB1 was moderately correlated with CRP in infectious diseases subgroup, and the serum concentration of anti-HMGB1 antibodies was strongly correlated with erythrocyte sedimentation rate in autoimmune disease subgroup. Our study had showed that serum HMGB1/anti-HMGB1 antibodies ratio can help clinicians identify FUO subtypes, thereby avoiding many unnecessary examinations and tests, and improving the effectiveness of clinical diagnosis and treatment of FUO.

scholarly journals Dermal Enhancement: Bacterial Products on Intact Skin Induce and Augment Organ-Specific Autoimmune Disease

2003 ◽  
Vol 172 (1) ◽  
pp. 302-309 ◽  
Author(s):  
D. Sean Riminton ◽  
Rama Kandasamy ◽  
Danijela Dravec ◽  
Antony Basten ◽  
Alan G. Baxter
Keyword(s):  
Autoimmune Disease ◽  
Intact Skin ◽  
Organ Specific ◽  
Bacterial Products

scholarly journals Rare presentation of a testicular angiofibroma treated with testis sparing surgery

2016 ◽  
Vol 88 (4) ◽  
pp. 330 ◽  
Author(s):  
Luca Leone ◽  
Paola Fulvi ◽  
Giulia Sbrollini ◽  
Alessandra Filosa ◽  
Enrico Caraceni ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Tumor ◽  
Gold Standard ◽  
Conservative Surgery ◽  
Pathological Examination ◽  
Benign Tumors ◽  
Frozen Sections ◽  
Rare Presentation ◽  
Final Histology

Introduction: Testicular benign tumors are very rare (< 5%). Testicular Angiofibroma (AF) is one of those, however the gold standard of treatment and follow-up is still unclear. Case report: A 47 years-old man with only one functioning testis was referred to our clinic for a palpable right testicular mass and atrophic contralateral testis. Patient underwent testis-sparing surgery with inguinal approach and intraoperative frozen sections examination with diagnosis of AF. Final histology confirmed AF. Post-operative follow-up was uneventful. Clinical and ultrasonographic follow-up was negative after 8 months. Conclusion: We report a conservative surgery in a patient with AF of the solitary testis. AF is a benign para-testicular fibrous neoplasm that could be misinterpreted as malignant tumor and treated with orchiectomy. Testis-sparing surgery is recommended in this case with intraoperative pathological examination. The excision of the mass is enough but in front of a possible recurrence a long follow-up is advisable.

scholarly journals Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

2013 ◽  
Vol 110 (7) ◽  
pp. 2599-2604 ◽  
Author(s):  
K. D. Mason ◽  
A. Lin ◽  
L. Robb ◽  
E. C. Josefsson ◽  
K. J. Henley ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Organ Specific

Deviant proteome profile of equine granulocytes associates to latent activation status in organ specific autoimmune disease

2021 ◽  
Vol 230 ◽  
pp. 103989
Author(s):  
Maria Weigand ◽  
Stefanie M. Hauck ◽  
Cornelia A. Deeg ◽  
Roxane L. Degroote
Keyword(s):  
Autoimmune Disease ◽  
Organ Specific ◽  
Proteome Profile ◽  
Activation Status

scholarly journals Drug utilization in treatment of thyroid disorders during pregnancy in Serbia

2016 ◽  
Vol 69 (1-2) ◽  
pp. 11-15
Author(s):  
Olga Horvat ◽  
Zdenko Tomic ◽  
Vesna Mijatovic ◽  
Ana Sabo
Keyword(s):  
Pregnant Woman ◽  
Thyroid Gland ◽  
Drug Utilization ◽  
Thyroid Dysfunction ◽  
Hashimoto Thyroiditis ◽  
Thyroid Disorders ◽  
Thyroid Disorder ◽  
Study Results ◽  
Novi Sad

Introduction. Depleted uranium radiation and pollution with polychlorinated biphenyls resulting from bombings the territories of Serbia as well as the additional long-term stress may have affected the function of thyroid gland. The objective of this study was to determine the trend of drug utilization in the treatment of thyroid dysfunction during pregnancy in Novi Sad. Material and Methods. Women who had given birth at the Department of Gynecology in 1989, 1999, 2007 and 2011 were interviewed during a one-month period about thyroid diseases in the pregnancy as well as the drugs they had taken. Results. Not a single pregnant woman was reported to have a thyroid disorder in 1989 and 1999, while in 2007 four women were reported to have a thyroid dysfunction. In 2011, fourteen out of 18 women with thyroid dysfunction were using levothyroxine and in most cases hypothyroidism was diagnosed as autoimmune Hashimoto thyroiditis. Conclusion. The study results suggest the necessity of performing more detailed analyses of the correlation between the frequency of the thyroid gland dysfunction and the effects of environmental pollution in Serbia.

scholarly journals Serum immunoglobulin a deficiency and autoimmune comorbidities: a crossectional study in 281 patients with systemic lupus erythematosus

2020 ◽  
Vol 66 (6) ◽  
pp. 752-756
Author(s):  
Gustavo Felício Alexandroni Linzmeyer ◽  
Fabiane Karen Miyake ◽  
Thiago Alberto F. C. Gomes Dos Santos ◽  
Thelma L Skare
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Clinical Data ◽  
Lupus Erythematosus ◽  
Immunoglobulin A ◽  
Hashimoto Thyroiditis ◽  
Iga Deficiency ◽  
Systemic Lupus ◽  
High Prevalence

SUMMARY OBJECTIVE To study the profile of associated autoimmune diseases in a series of patients with systemic lupus erythematosus (SLE) and see if such associations are linked to IgA deficiency. METHODS Two hundred eighty-one patients with SLE were studied for Ig A levels by nephelometry. Levels equal to or under 0.05g/dL were considered as IgA deficiency. Epidemiological and clinical data, including the presence of associated autoimmune diseases, were extracted from the patient’s charts. RESULTS Ig A deficiency was found in 6% of the patients. In 30.2% of SLE patients, there was at least one more autoimmune disease; Hashimoto thyroiditis and Sjögren’s syndrome were the most common. No association between the occurrence of associated autoimmune disease with IgA deficiency was found. CONCLUSIONS There is a high prevalence of autoimmune diseases associated with SLE. IgA deficiency does not affect the presence of these associations.

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