Background:
Due to significant biological activity associated with N-, O- and S-heterocycles, a
number of reports for their synthesis have appeared in recent decades. Traditional approaches require expensive
or highly specialized equipment or would be of limited use to the synthetic organic chemist due to their
highly inconvenient approaches. This review summarizes the applications of copper catalysts with the
emphasis on their synthetic applications for nitrogen bearing polyheterocylces. In summary, this review article
describes the synthesis of a number of five-membered poly heterocyclic rings.
Objective:
Nowadays new approaches that employ atom-economical and efficient pathway have been developed.
The researchers are following natural models to design and synthesize heterocycles. The transition metal
catalyzed protocols have attracted the attention as compared to other synthetic methodologies because they use
easily available substrates to build multiple substituted complicated molecules directly under mild conditions.
In organic synthesis, constituted by transition metal catalyzed coupling transformations are one of the most
powerful and useful protocols. The N-heterocycles are synthesized by this convenient and useful tool.
Conclusion:
The efficient and chemoselective synthesis of heterocycles by this technique has appeared as an
important tool. This review shows a highly dynamic research field and the employment of copper catalysts in
organic synthesis. Several strategies have been pointed out in the past few years, to meet more sustainable, efficient
and environmentally benign chemical products and procedures. The catalytic strategies have been the
focus of intense research because they avoid the use of toxic reagents. Among these catalytic strategies, highly
rewarding and an important method in heterocycles synthesis is metal catalyzed synthesis.
Metal-catalyzed organic reactions by Resonant Acoustic Mixing
