The Socio-Cultural and Confessional Dimension of Delusional Ideas Content in the Spectrum of Non-Organic Psychotic Disorders

In the last decade, population clinical trials support the disabling nature of most globally diagnosed psychotic disorders. As a defining integral part of this pathology, the delusional idea considered to be the result of the inaccurate and abnormal interpretation of an external reality is individualized, despite the contrary evidence. This ideation’s clinical expression variability is influenced by a heterogeneous spectrum of biological and psychosocial factors, predisposing and/or favouring. This review’s main objective is to identify a series of relational patterns of the content of delusional ideation with socio-familial and cultural/confessional parameters to obtain a holistic approach to patients. Careful decipherment of these conditions can be the basis for developing new interventions that are much more effective in establishing a long-term diagnostic and therapeutic strategy.

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COVID-19 Response in Thailand and Its Implications on Future Preparedness

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18031089 ◽

2021 ◽

Vol 18 (3) ◽

pp. 1089

Author(s):

Wijitbusaba Marome ◽

Rajib Shaw

Keyword(s):

Early Stage ◽

Health Resources ◽

Holistic Approach ◽

Disaster Risk ◽

Community Level ◽

Multilateral Cooperation ◽

First Case ◽

Multiple Dimensions ◽

Economic And Social Impacts

Thailand has been affected by COVID-19, like other countries in the Asian region at an early stage, and the first case was reported as early as mid-January 2020. Thailand’s response to the COVID-19 pandemic has been guided by the “Integrated Plan for Multilateral Cooperation for Safety and Mitigation of COVID-19”. This paper analyses the health resources in the country and focuses on the response through community-level public health system and legislative measures. The paper draws some lessons on future preparedness, especially with respect to the four priorities of Sendai Framework for Disaster Risk Reduction. At the end, the paper puts some key learning for future preparedness. While Thailand’s response to COVID-19 has been effective in limiting the spread of the disease, it falls short at being able to address the multiple dimensions of the crisis such as the economic and social impacts. The socioeconomic sectors have been hardest hit, with significant impact on tourism sectors. Sociopolitical system also plays an important role in governance and decision-making for pandemic responses. The analysis suggests that one opportunity for enhancing resilience in Thailand is to strive for more multilevel governance that engages with various stakeholders and to support grassroots and community-level networks. The COVID-19 pandemic recovery is a chance to recover better while leaving no one behind. An inclusive long-term recovery plan for the various impacted countries needs to take a holistic approach to address existing gaps and work towards a sustainable society. Furthering the Health Emergency Disaster Risk Management (HEDRM) Framework may support a coordinated response across various linked sectors rather than straining one particular sector.

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MODL-16. ABEMACICLIB, A SELECTIVE CDK4/6 INHIBITOR, RESTRICTS GROWTH OF PEDIATRIC GLIAL-LINEAGE TUMORS IN VITRO AND IN VIVO

Neuro-Oncology ◽

10.1093/neuonc/noaa222.590 ◽

2020 ◽

Vol 22 (Supplement_3) ◽

pp. iii414-iii414

Author(s):

Muh-Lii Liang ◽

Tsung-Han Hsieh ◽

Tai-Tong Wong

Keyword(s):

Dna Repair ◽

Therapeutic Strategy ◽

Target Genes ◽

Rna Seq ◽

Downstream Target ◽

Rb Phosphorylation ◽

Glial Lineage

Abstract BACKGROUND Glial-lineage tumors constitute a heterogeneous group of neoplasms, comprising gliomas, oligodendrogliomas, and ependymomas, which account for 40%–50% of all pediatric central nervous system tumors. Advances in modern neuro-oncological therapeutics are aimed at improving neoadjuvant chemotherapy and deferring radiotherapy because radiation exposure may cause long-term side effects on the developing brain in young children. Despite aggressive treatment, more than half the high-grade gliomas (pHGGs) and one-third of ependymomas exhibit recurrence within 2 years of initial treatment. METHODS By using integrated bioinformatics and through experimental validation, we found that at least one gene among CCND1, CDK4, and CDK6 was overexpressed in pHGGs and ependymomas. RESULTS The use of abemaciclib, a highly selective CDK4/6 inhibitor, effectively inhibited cell proliferation and reduced the expression of cell cycle–related and DNA repair–related gene expression, which was determined through RNA-seq analysis. The efficiency of abemaciclib was validated in vitro in pHGGs and ependymoma cells and in vivo by using subcutaneously implanted ependymoma cells from patient-derived xenograft (PDX) in mouse models. Abemaciclib demonstrated the suppression of RB phosphorylation, downstream target genes of E2F, G2M checkpoint, and DNA repair, resulting in tumor suppression. CONCLUSION Abemaciclib showed encouraging results in preclinical pediatric glial-lineage tumors models and represented a potential therapeutic strategy for treating challenging tumors in children.

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Tourism Productivity Theory and Measurement for Policy Implications: The Case of Australia

Journal of Travel Research ◽

10.1177/0047287519835972 ◽

2019 ◽

Vol 59 (2) ◽

pp. 247-266

Author(s):

Tien Duc Pham

Keyword(s):

Labor Productivity ◽

Holistic Approach ◽

Tourism Industry ◽

Policy Implications ◽

Policy Makers ◽

Average Growth ◽

Multifactor Productivity ◽

Capital Productivity ◽

Productivity Theory

Tourism productivity measures are quite diverse, not always compatible and usually based partly on labor productivity for hotels and restaurants. This article develops a holistic approach that integrates the principles of the growth accounting framework and tourism satellite account to measure multifactor productivity, labor productivity and capital productivity for the Australian tourism industry. This study shows that tourism has been identified as a reservoir for other industries through the ebbs and flows of labor demands. Compared with the rest of the economy, the average growth of labor productivity—that is, income per unit of labor—for tourism is stagnant, and has reached an unprecedented low, six times below the market sector average, mainly because of low multifactor productivity. The results are valuable for policy makers and the lobbying groups wanting to identify areas of need for policy changes to ensure the healthy long-term growth of tourism.

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Therapeutic Strategy for Chronic Pancreatitis From Long-Term Outcome, Medical Treatment Vs. Surgical Treatment

Pancreas ◽

10.1097/01.mpa.0000371194.63075.9e ◽

2010 ◽

Vol 39 (5) ◽

pp. 696

Author(s):

Kazunori Takeda ◽

Terumi Kamisawa.

Keyword(s):

Chronic Pancreatitis ◽

Surgical Treatment ◽

Medical Treatment ◽

Therapeutic Strategy ◽

Term Outcome ◽

Long Term Outcome

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Evaluation of the inhibitory potential of essential oils and aromatic extracts on SARS-CoV-2 Mpro and PLpro

10.21203/rs.3.rs-997891/v1 ◽

2021 ◽

Author(s):

Daniel Strub ◽

Michał Talma ◽

Maria Strub ◽

Wioletta Rut ◽

Mikołaj Żmudziński ◽

...

Keyword(s):

Essential Oils ◽

Exploratory Study ◽

Therapeutic Strategy ◽

Plant Materials ◽

Highly Pathogenic ◽

Significant Growth ◽

Volatile Products ◽

Inhibitory Potential ◽

Human Coronaviruses

Abstract Essential oils and aromatic extracts (oleoresins, absolutes, concretes, resinoids) are often used as food flavorings and constituents of fragrance compositions. The flavor and fragrance industry observes significant growth in sales of some natural materials during the COVID-19 outbreak. Some companies worldwide are making false claims regarding their essential oils or blends to be effective (or indirectly points towards this conclusion) against coronaviruses even though the available data on the activity of plant materials against highly pathogenic human coronaviruses is very scarce. Our exploratory study aimed to develop pioneering knowledge, and provide the first experimental results on the inhibitory properties of hundreds of flavor & fragrance materials against SARS-CoV-2 main- and papain-like proteases. As essential oils are volatile products, they could provide an interesting subsidiary inhalation therapeutic strategy in the long term.

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‘Home, Sweet Home’: Managing Returning Foreign Terrorist Fighters in Germany, The United Kingdom and Australia

International Community Law Review ◽

10.1163/18719732-12341378 ◽

2018 ◽

Vol 20 (3-4) ◽

pp. 311-346 ◽

Cited By ~ 1

Author(s):

Kerstin Braun

Keyword(s):

United Kingdom ◽

Criminal Justice ◽

Holistic Approach ◽

Security Threats ◽

Security Risks ◽

Western Countries ◽

The United Kingdom

Abstract Since 2011, the conflict in Syria and Iraq has seen unprecedented numbers of Westerners travelling to the region to support jihadist terror organisations, so-called Foreign Terrorist Fighters (‘FTFs’). However, since 2015, with Islamic State’s financial and territorial losses, the numbers of Western FTFs are dwindling and many are returning to their countries of origin. As a consequence, numerous countries are grappling with how to best manage potential security threats arising from returning FTFs. This article critically analyses legal and criminal justice strategies to address this phenomenon implemented in three Western countries from which a significant number of FTFs originate: Germany, the United Kingdom and Australia. It focuses on prosecution, prevention of re-entry and rehabilitation of returning FTFs. It suggests that a holistic approach focusing on punitive but also on de-radicalising and reintegrating measures is best suited to address the security risks FTFs pose long term.

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Neural Transplantation

Cell Transplantation ◽

10.1177/096368979500400410 ◽

1995 ◽

Vol 4 (4) ◽

pp. 393-400 ◽

Cited By ~ 17

Author(s):

Olle Lindvall

Keyword(s):

Cell Transplantation ◽

Therapeutic Strategy ◽

Symptomatic Relief ◽

Animal Experiments ◽

Research Field ◽

Term Survival ◽

Demyelinating Disorders ◽

And Function ◽

Further Development

Cell transplantation is now being explored as a new therapeutic strategy to restore function in the diseased human central nervous system. Neural grafts show long-term survival and function in patients with Parkinson's disease but the symptomatic relief needs to be increased. Cell transplantation seems justified in patients with Huntington's disease and, at a later stage, possibly also in demyelinating disorders. The further development in this research field will require systematic studies in animal experiments but also well-designed clinical trials in small groups of patients.

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Paleoenvironmental Reconstructions Improve Ecosystem Services Risk Assessment: Case Studies from Two Coastal Lagoons in South America

Water ◽

10.3390/w10101350 ◽

2018 ◽

Vol 10 (10) ◽

pp. 1350 ◽

Cited By ~ 4

Author(s):

Maria Velez ◽

Daniel Conde ◽

Juan Lozoya ◽

James Rusak ◽

Felipe García-Rodríguez ◽

...

Keyword(s):

Risk Assessment ◽

Risk Management ◽

Ecosystem Services ◽

South America ◽

Coastal Lagoons ◽

Holistic Approach ◽

Assessment Process ◽

History Of ◽

Paleoenvironmental Reconstructions

Paleoenvironmental reconstructions are increasingly being used in conservation biology, ecosystem management, and evaluations of ecosystem services (ES), but their potential to contribute to the ES risk assessment process has not been explored. We propose that the long-term history of the ecosystem provides valuable information that augments and strengthens an ES risk assessment and that it should be considered routinely when undertaking risk assessments. We adjusted a standard ecosystem-based risk management (EBRM) protocol to include paleoenvironmental data, and tested the modified approach on two coastal lagoons in South America. Paleolimnological reconstructions in both lagoons indicate that salinity and nutrients (in Laguna de Rocha), and salinity (in Ciénaga Grande de Santa Marta), as controlled by hydrologic connectivity with the ocean and freshwater tributaries, have been the key variables behind ecosystem’s function. This understanding, applied to inform various components and steps in the EBRM protocol, suggests that the maintenance of hydrological connections should be a management priority to minimize risk to ES. This work illustrates the utility of including paleoenvironmental data in an EBRM context and highlights the need for a more holistic approach to risk management by incorporating the long-term history of ecosystem function.

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Data-Driven Decision Making: An Holistic Approach to Assessment in Special Collections Repositories

Evidence Based Library and Information Practice ◽

10.18438/b8d03m ◽

2013 ◽

Vol 8 (2) ◽

pp. 225 ◽

Cited By ~ 3

Author(s):

Melanie Griffin ◽

Barbara Lewis ◽

Mark I. Greenberg

Keyword(s):

Single Case ◽

Holistic Approach ◽

Assessment Model ◽

Digital Collections ◽

Skill Sets ◽

Special Collections ◽

Day To Day Operations ◽

Technical Services

Objective – In an environment of shrinking budgets and reduced staffing, this study seeks to identify a comprehensive, integrated assessment strategy to better focus diminished resources within special collections repositories. Methods – This article presents the results of a single case study conducted in the Special and Digital Collections department at a university library. The department created an holistic assessment model, taking into account both public and technical services, to explore inter-related questions affecting both day-to-day operations as well as long-term, strategic priorities. Results – Data from a variety of assessment activities positively impacted the department’s practices, informing decisions made about staff skill sets, training, and scheduling; outreach activities; and prioritizing technical services. The results provide a comprehensive view of both patron and department needs, allowing for a wide variety of improvements and changes in staffing practices, all driven by data rather than anecdotal evidence. Conclusion – Although the data generated for this study is institutionally specific, the methodology is applicable to special collections departments at other institutions. A systemic, holistic approach to assessment in special collections departments enables the implementation of operational efficiencies. It also provides data that allows the department to document its value to university-wide stakeholders.

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