Dietary vitamin A supplementation improved reproductive performance by regulating ovarian expression of hormone receptors, caspase-3 and Fas in broiler breeders

To determine the effects of dietary vitamin A on the activity of the mixed function oxidase (MFO) system and on the susceptibility to 3-methylindole (3MI)-induced respiratory disease, goats were fed a high (supplemented with 12 000 IU retinyl palmitate/kg) or a low (no supplementation) vitamin A diet for 14 weeks. Four animals in each dietary group were then challenged with [14C]3MI. The remaining four animals served as controls. Enzyme assays were performed and severity of the 3MI-induced lung damage was scored. Consumption of the low vitamin A diet resulted in a significant reduction in the liver and lung contents of vitamin A; however, serum concentration of vitamin A was unaffected. High vitamin A supplementation did not alter the activity of the MFO system. Clinical signs, lung – body weight ratio and wet – dry weight ratio of the lungs of 3MI-infused goats were not significantly different; however, in the low vitamin A goats, the microscopic lesions such as the extent of alveolar epithelial hyperplasia were judged to be significantly more severe than those observed in the high vitamin A goats.

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Vitamin A deficiency among children younger than 5 y in India: an analysis of national data sets to reflect on the need for vitamin A supplementation

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqaa314 ◽

2020 ◽

Author(s):

G Bhanuprakash Reddy ◽

Raghu Pullakhandam ◽

Santu Ghosh ◽

Naveen K Boiroju ◽

Shalini Tattari ◽

...

Keyword(s):

Vitamin A ◽

Vitamin A Deficiency ◽

Public Health Problem ◽

Sample Survey ◽

Dietary Vitamin ◽

High Dose ◽

Serum Retinol ◽

Indian Children ◽

Vitamin A Supplementation ◽

National Prevalence

ABSTRACT Background Biochemical vitamin A deficiency (VAD) is believed to be a serious public health problem (low serum retinol prevalence >20%) in Indian children, justifying universal high-dose vitamin A supplementation (VAS). Objective To evaluate in Indian children younger than 5 y the risk of biochemical VAD from the Comprehensive National Nutrition Survey, as well as dietary vitamin A inadequacy and excess over the tolerable upper limit of intake (TUL) from national and subnational surveys, factoring in fortification and VAS. Methods Child serum retinol data, corrected for inflammation, were examined to evaluate national- and state-level prevalence of VAD. Simultaneously, dietary intakes from the National Sample Survey Office and the National Nutrition Monitoring Bureau were examined for risk of dietary vitamin A deficiency against its average requirement (AR) derived for Indian children. Theoretical estimates of risk reduction with oil and milk vitamin A fortification were evaluated along with the risk of exceeding the TUL, as well as when combined with intake from VAS. Results The national prevalence of biochemical VAD measured in 9563 children was 15.7% (95% CI: 15.2%, 16.3%), and only 3 states had prevalence significantly >20%. The AR of vitamin A was 198 and 191 µg/d for boys and girls; the risk of dietary inadequacy was ∼70%, which reduced to 25% with oil and milk fortification. Then, the risk of exceeding the TUL was 2% and 1% in 1- to 3-y-old and 4- to 5-y-old children, respectively, but when the VAS dose was added to this intake in a cumulative 6-mo framework, the risk of exceeding the TUL rose to 30% and 8%, respectively. Conclusion The national prevalence of VAD risk is below 20% in Indian children. Because there is risk of excess intake with food fortification and VAS, serious consideration should be given to a targeted approach in place of the universal VAS program in India.

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The effect of dietary vitamin A supplementation in maternal and its offspring on the early growth performance, liver vitamin A content, and antioxidant index of goslings

Poultry Science ◽

10.3382/ps/pez432 ◽

2019 ◽

Vol 98 (12) ◽

pp. 6849-6856 ◽

Cited By ~ 1

Author(s):

J.R. Liang ◽

H. Dai ◽

H.M. Yang ◽

Z. Yang ◽

Z.Y. Wang

Keyword(s):

Vitamin A ◽

Growth Performance ◽

Early Growth ◽

Dietary Vitamin ◽

Vitamin A Supplementation ◽

Liver Vitamin

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The effect of vitamin A supplementation in broodstock feed on reproductive performance and larval quality in Penaeus chinensis

Aquaculture Nutrition ◽

10.1111/j.1365-2095.2004.00302.x ◽

2004 ◽

Vol 10 (5) ◽

pp. 295-300 ◽

Cited By ~ 10

Author(s):

L. Mengqing ◽

J. Wenjuan ◽

C. Qing ◽

W. Jialin

Keyword(s):

Vitamin A ◽

Reproductive Performance ◽

Vitamin A Supplementation ◽

Penaeus Chinensis ◽

Larval Quality

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Dietary Vitamin A Supplementation Decreases Colorectal Cancer Liver Metastases in Mice

The FASEB Journal ◽

10.1096/fasebj.23.1_supplement.730.2 ◽

2009 ◽

Vol 23 (S1) ◽

Author(s):

Jennifer Griffin ◽

Eun Young Park ◽

Michelle A Lane

Keyword(s):

Colorectal Cancer ◽

Vitamin A ◽

Liver Metastases ◽

Dietary Vitamin ◽

Colorectal Cancer Liver Metastases ◽

Vitamin A Supplementation

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The effect of retinyl palmitate added to iron-fortified maize porridge on erythrocyte incorporation of iron in African children with vitamin A deficiency

British Journal Of Nutrition ◽

10.1079/bjn2003914 ◽

2003 ◽

Vol 90 (2) ◽

pp. 337-343 ◽

Cited By ~ 15

Author(s):

Lena Davidsson ◽

Pierre Adou ◽

Christophe Zeder ◽

Thomas Walczyk ◽

Richard Hurrell

Keyword(s):

Single Dose ◽

Vitamin A ◽

Test Meal ◽

Vitamin A Deficiency ◽

Geometric Mean ◽

Retinyl Palmitate ◽

Dietary Vitamin ◽

Vitamin A Supplementation ◽

Vitamin A Status ◽

Before And After

Retinyl palmitate added to Fe-fortified maize bread has been reported to enhance Fe absorption in adult Venezuelan subjects but not in Western Europeans. It is not known to what extent these results were influenced by differences in vitamin A status of the study subjects. The objective of the present study was to evaluate the influence of retinyl palmitate added to Fe-fortified maize porridge on erythrocyte incorporation of Fe in children with vitamin A deficiency, before and after vitamin A supplementation. Erythrocyte incorporation of Fe-stable isotopes was measured 14 d after intake of maize porridge (2·0 mg Fe added as ferrous sulfate) with and without added retinyl palmitate (3·5 μmol; 3300 IU). The study was repeated 3 weeks after vitamin A supplementation (intake of a single dose of 210 μmol retinyl palmitate; ‘vitamin A capsule’). Vitamin A status was evaluated by the modified relative dose–response (MRDR) technique. Retinyl palmitate added to the test meal reduced the geometric mean erythrocyte incorporation of Fe at baseline from 4·0 to 2·6 % (P=0·008, n 13; paired t test). At 3 weeks after vitamin A supplementation, geometric mean erythrocyte incorporation was 1·9 and 2·3 % respectively from the test meal with and without added retinyl palmitate (P=0·283). Mean dehydroretinol:retinol molar ratios were 0·156 and 0·125 before and after intake of the single dose of 210 μmol retinyl palmitate; ‘vitamin A capsule’ (P=0·15). In conclusion, retinyl palmitate added to the labelled test meals significantly decreased erythrocyte incorporation of Fe in children with vitamin A deficiency at baseline but had no statistically significant effect 3 weeks after vitamin A supplementation. The difference in response to retinyl palmitate added to Fe-fortified maize porridge on erythrocyte incorporation of Fe before and after intake of the vitamin A capsule indicates, indirectly, changes in vitamin A status not measurable by the MRDR technique. The lack of conclusive data on the effect of retinyl palmitate on Fe absorption indicates the complexity of the interactions between vitamin A status, dietary vitamin A and Fe metabolism.

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