scholarly journals Clinical assessment of growth performance, bone morphometry, bone quality, and serum indicators in broilers affected by valgus-varus deformity

2019 ◽  
Vol 98 (10) ◽  
pp. 4433-4440 ◽  
Author(s):  
Yaping Guo ◽  
Hehe Tang ◽  
Xiangnan Wang ◽  
Wenting Li ◽  
Yanbin Wang ◽  
...  

BMC Genomics ◽  
2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Yaping Guo ◽  
Hetian Huang ◽  
Zhenzhen Zhang ◽  
Yanchao Ma ◽  
Jianzeng Li ◽  
...  

Abstract Background Valgus-varus deformity (VVD) is a lateral or middle deviation of the tibiotarsus or tarsometatarsus, which is associated with compromised growth, worse bone quality and abnormal changes in serum indicators in broilers. To investigate the genetic basis of VVD, a genome wide association study (GWAS) was performed to identify candidate genes and pathways that are responsible for VVD leg disease, serum indicators and growth performance in broilers. Results In total, VVD phenotype, seven serum indicators and three growth traits were measured for 126 VVD broilers (case group) and 122 sound broilers (control group) based on a high throughput genome wide genotyping-by-sequencing (GBS) method. After quality control 233 samples (113 sound broilers and 120 VVD birds) and 256,599 single nucleotide polymorphisms (SNPs) markers were used for further analysis. As a result, a total of 5 SNPs were detected suggestively significantly associated with VVD and 70 candidate genes were identified that included or adjacent to these significant SNPs. In addition, 43 SNPs located on Chr24 (0.22 Mb - 1.79 Mb) were genome-wide significantly associated with serum alkaline phosphatase (ALP) and 38 candidate genes were identified. Functional enrichment analysis showed that these genes are involved in two Gene Ontology (GO) terms related to bone development (cartilage development and cartilage condensation) and two pathways related to skeletal development (Toll−like receptor signaling pathway and p53 signaling pathway). BARX2 (BARX homeobox 2) and Panx3 (Pannexin 3) related to skeleton diseases and bone quality were obtained according to functional analysis. According to the integration of GWAS with transcriptome analysis, HYLS1 (HYLS1 centriolar and ciliogenesis associated) was an important susceptibility gene. Conclusions The results provide some reference for understanding the relationship between metabolic mechanism of ALP and pathogenesis of VVD, which will provide a theoretical basis for disease-resistant breeding of chicken leg soundness.



1993 ◽  
Vol 53 (S1) ◽  
pp. S150-S150
Author(s):  
Robert Heaney


2015 ◽  
Vol 30 (1) ◽  
pp. 196-201 ◽  
Author(s):  
Athanasios Ntounis ◽  
Nico Geurs ◽  
Philip Vassilopoulos ◽  
Michael Reddy


2017 ◽  
Vol 26 (2) ◽  
pp. 131-140 ◽  
Author(s):  
K. Kwiatkowska ◽  
M. Kwiecień ◽  
A. Winiarska-Mieczan


2004 ◽  
Vol 13 (2) ◽  
pp. 311-318 ◽  
Author(s):  
J.R. Timmons ◽  
J.M. Harter-Dennis ◽  
A.E. Sefton


2014 ◽  
Vol 27 (2) ◽  
pp. 237-246 ◽  
Author(s):  
Z. K. Zeng ◽  
D. Wang ◽  
X. S. Piao ◽  
P. F. Li ◽  
H. Y. Zhang ◽  
...  


2018 ◽  
Vol 59 (3) ◽  
pp. 318-329 ◽  
Author(s):  
B. Koçer ◽  
M. Bozkurt ◽  
G. Ege ◽  
A. E. Tüzün ◽  
R. Konak ◽  
...  


2016 ◽  
Vol 191 ◽  
pp. 43-50 ◽  
Author(s):  
Małgorzata Kwiecień ◽  
Anna Winiarska-Mieczan ◽  
Anna Milczarek ◽  
Ewa Tomaszewska ◽  
Jan Matras


2021 ◽  
Vol 24 (2) ◽  
pp. 109-120
Author(s):  
Y. Shabban ◽  
F. Abdel Azeem ◽  
H. Thabet ◽  
A. El. Faham ◽  
Nematallah Ali ◽  
...  


2016 ◽  
Vol 45 (1) ◽  
pp. 423-429 ◽  
Author(s):  
Nazim Rasul Abdulla ◽  
Teck Chwen Loh ◽  
Henny Akit ◽  
Awis Qurni Sazili ◽  
Hooi Ling Foo ◽  
...  


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