Clinical Assessment of Bone Quality of Human Extraction Sockets After Conversion with Growth Factors

2015 ◽  
Vol 30 (1) ◽  
pp. 196-201 ◽  
Author(s):  
Athanasios Ntounis ◽  
Nico Geurs ◽  
Philip Vassilopoulos ◽  
Michael Reddy
Keyword(s):  
Growth Factors ◽  
Bone Quality ◽  
Clinical Assessment

MALIGNANT TUMORS ASSOCIATED WITH METABOLIC SYNDROME: THE EXPRESSION PROFILE OF THE TRANSCRIPTIONAL AND GROWTH FACTORS

2017 ◽  
Vol 63 (6) ◽  
pp. 817-823
Author(s):  
Natalya Yunusova ◽  
Irina Kondakova ◽  
Sergey Afanasev ◽  
Larisa Kolomiets ◽  
Alena Chernyshova
Keyword(s):  
Quality Of Life ◽  
Metabolic Syndrome ◽  
Growth Factors ◽  
Cell Motility ◽  
Expression Profile ◽  
Malignant Tumors ◽  
Molecular Targets ◽  
Factors Associated ◽  
High Incidence

The study of the pathogenetic features of malignant tumors associated with metabolic syndrome (MS) is relevant because of high incidence of these tumors. Investigations of the mechanisms of involvement of MS in the pathogenesis of cancer reasonably supplemented by the study of transcription and growth factors associated with energy imbalance of the cell and involved in proliferation, apoptosis, angiogenesis, cell motility and inflammation. More research is needed to identify the most promising molecular targets for therapy of malignant tumors associated with MS with a view to increasing the survival and quality of life of these patients.

scholarly journals Computed Tomographic Evaluation of Bone Quality of the Mandible Reconstructed by Particular Cellular Bone and Marrow Combined with Platelet Rich Plasma

2009 ◽  
Vol 6 (2) ◽  
pp. 63-72 ◽  
Author(s):  
Muneharu Iwamoto ◽  
Akira Matsuo ◽  
Noriko Kato ◽  
Sawako Takeuchi ◽  
Hidetoshi Takahashi ◽  
...  
Keyword(s):  
Bone Quality ◽  
Platelet Rich Plasma ◽  
Computed Tomographic ◽  
Cellular Bone

scholarly journals Dietary hybrid phytase and carbohydrases on nutrient digestibility and bone quality of broiler chickens

2021 ◽  
Vol 56 ◽  
Author(s):  
Caroline Bavaresco ◽  
Everton Luis Krabbe ◽  
Diego Surek ◽  
Edenilse Gopinger ◽  
Fernando Nicolas Martinez ◽  
...  
Keyword(s):  
Bone Quality ◽  
Broiler Chickens ◽  
Basal Diet ◽  
Positive Control ◽  
Nutrient Digestibility ◽  
Metabolizable Energy ◽  
Available P ◽  
Available Phosphorus ◽  
Poultry Diets

Abstract The objective of this work was to evaluate the effect of the use of hybrid phytase, alone or combined with carbohydrases, in poultry diets with nutritional reductions of calcium, available phosphorus, and metabolizable energy on the nutrient digestibility and bone quality of broiler chickens. A total of 1,875 broilers were distributed in five treatments in a completely randomized design, with 15 replicates of 25 chickens each. The treatments consisted of a positive control feed (T1) and of four negative controls (T2 to T5): T1, basal diet (BD) with corn and soybean; T2 and T3, BDs with reductions of 70 and 100 kcal kg-1 metabolizable energy, respectively, and both with reductions of 0.16% Ca and 0.15% available P; and T4 and T5, BDs with the same nutritional reductions, but supplemented with enzymes, i.e., T4 = T2 + 500 phytase units (FTU) per kilogram and T5 = T3 + 500 FTU kg-1 + 560 xylanase units (TXU) per kilogram + 250 glucanase units (TGU) per kilogram. The use of 500 FTU kg-1 hybrid phytase in pelleted corn-soybean meal diets allows a good digestive performance by broilers and replaces the nitrogen-corrected apparent metabolizable energy at 70 kcal kg-1, as well as 0.16% Ca and 0.15% available P.

scholarly journals Impact of radiofrequency ablation (RFA) on bone quality in a murine model of bone metastases

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0256076
Author(s):  
Soroush Ghomashchi ◽  
Cari M. Whyne ◽  
Tricia Chinnery ◽  
Fayez Habach ◽  
Margarete K. Akens
Keyword(s):  
Radiofrequency Ablation ◽  
Bone Metastases ◽  
Tumor Cells ◽  
Bone Quality ◽  
Second Harmonic ◽  
Local Treatment ◽  
Skeletal Metastases ◽  
The Impact ◽  
Surrounding Bone

Thermal therapies such as radiofrequency ablation (RFA) are gaining widespread clinical adoption in the local treatment of skeletal metastases. RFA has been shown to successfully destroy tumor cells, yet the impact of RFA on the quality of the surrounding bone has not been well characterized. RFA treatment was performed on femora of rats with bone metastases (osteolytic and osteoblastic) and healthy age matched rats. Histopathology, second harmonic generation imaging and backscatter electron imaging were used to characterize changes in the structure, organic and mineral components of the bone after RFA. RFA treatment was shown to be effective in targeting tumor cells and promoting subsequent new bone formation without impacting the surrounding bone negatively. Mineralization profiles of metastatic models were significantly improved post-RFA treatment with respect to mineral content and homogeneity, suggesting a positive impact of RFA treatment on the quality of cancer involved bone. Evaluating the impact of RFA on bone quality is important in directing the growth of this minimally invasive therapeutic approach with respect to fracture risk assessment, patient selection, and multimodal treatment planning.

scholarly journals Bone Quality of the Dento-Maxillofacial Complex and Osteoporosis. Opportunistic Radiographic Interpretation

2021 ◽  
Author(s):  
Plauto Christopher Aranha Watanabe ◽  
Giovani Antonio Rodrigues ◽  
Marcelo Rodrigues Azenha ◽  
Michel Campos Ribeiro ◽  
Enéas de Almeida Souza Filho ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Quality ◽  
Bone Mineral ◽  
Panoramic Radiography ◽  
Mineral Density ◽  
Radiographic Findings ◽  
Radiographic Interpretation ◽  
Auxiliary Mechanism

Research suggests the use of different indexes on panoramic radiography as a way to assess BMD and to be able to detect changes in bone metabolism before fractures occur. Therefore, the objective of this chapter is to describe the use of these parameters as an auxiliary mechanism in the detection of low bone mineral density, as well as to characterize the radiographic findings of patients with osteoporosis.

scholarly journals Limestone particle sizes and lighting regimens on egg and bone quality of laying hens

2015 ◽  
Vol 50 (8) ◽  
pp. 718-725 ◽  
Author(s):  
Regina Patrícia de Souza Xavier ◽  
Ednardo Rodrigues Freitas ◽  
Nádia Melo Braz ◽  
Nadja Naiara Pereira Farias ◽  
Raffaella Castro Lima ◽  
...  
Keyword(s):  
Bone Quality ◽  
Laying Hens ◽  
Egg Quality ◽  
Mineral Matter ◽  
Artificial Light ◽  
Particle Sizes ◽  
Randomized Design ◽  
Completely Randomized Design ◽  
Haugh Unit

Abstract:The objective of this work was to evaluate the effect of limestone particle sizes in the diet and of lighting regimes on the egg and bone quality and on the performance of commercial laying hens. Three hundred Hissex White layers, at 18 weeks of age, were distributed in a completely randomized design, in a 5×2 factorial arrangement (coarse limestone in the diet at 0, 25, 50, 75, and 100%; with or without artificial light), with five replicates of six birds. No significant interaction was observed between particle sizes and lighting regime for the evaluated parameters. There was no significant effect of coarse limestone level in the diet on the performance and egg quality of hens; however, bone deformity (3.23 to 4.01 mm), strength (5.19 to 6.70 kgf cm-2), and mineral matter (51.09 to 59.61%) improved as the proportion of coarse limestone increased. For lighting regime, the treatment with artificial light yielded higher Haugh unit values (87.17 vs. 85.54) than that with natural light only. Greater limestone particles improve bone quality of laying hens, and the use of artificial light can benefit the albumen quality of the eggs.

scholarly journals Release of growth factors after mechanical and chemical pleurodesis for treatment of malignant pleural effusion: a randomized control study

2015 ◽  
Vol 49 (4) ◽  
pp. 386-394 ◽  
Author(s):  
Aljaz Hojski ◽  
Maja Leitgeb ◽  
Anton Crnjac
Keyword(s):  
Quality Of Life ◽  
Growth Factors ◽  
Growth Factor ◽  
Pleural Effusion ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Transforming Growth Factor ◽  
Chemical Pleurodesis ◽  
Thoracic Drainage

Abstract Background. Growth factors are key inducers of fibrosis but can also mediate inflammatory responses resulting in increasing pleural effusion and acute respiratory distress syndrome. The primary aim of the study was to analyse growth factors release after performing chemical and mechanical pleurodesis in the first 48 hours at the patients with malignant pleural effusion. The secondary endpoints were to evaluate the effectiveness of the both pleurodeses, symptoms release and the quality of life of patients after the treatment. Patients and methods. A prospective randomized study included 36 consecutive female patients with breast carcinoma and malignant pleural effusion in an intention-to-treat analysis. We treated 18 patients by means of thoracoscopic mechanical pleurodesis and 18 patients by chemical pleurodesis with talcum applied over a chest tube. We gathered the pleural fluid and serum samples in the following 48 hours under a dedicated protocol and tested them for growth factors levels. A quality of life and visual analogue pain score surveys were also performed. Results. Median measured serum vascular endothelial growth factor (VEGF) level after chemical pleurodesis was 930.68 pg/ml (95% CI: 388.22–4656.65) and after mechanical pleurodesis 808.54 pg/ml. (95% CI: 463.20-1235.13) (p = 0.103). Median pleural levels of transforming growth factor (TGF) β1 were higher after performing mechanical pleurodesis (4814.00 pg/ml [95% CI: 2726.51–7292.94]) when compared to those after performing chemical pleurodesis (1976.50 pg/ml [95% CI: 1659.82–5136.26]) (p = 0.078). We observed similar results for fibroblast growth factor (FGF) β; the serum level was higher after mechanical pleurodesis (30.45 pg/ml [95% CI: 20.40–59.42]), compared to those after chemical pleurodesis (13.39 pg/ml [95% CI: 5.04 – 74.60]) (p = 0.076). Mechanical pleurodesis was equally effective as chemical pleurodesis in terms of hospital stay, pleural effusion re-accumulation, requiring of additional thoracentesis, median overall survival, but, it shortened the mean thoracic drainage duration (p = 0.030) and resulted in a higher symptoms release and in a better quality of life (p = 0.047). Conclusions. We recorded an increase in serum VEGF levels after chemical pleurodesis, however on the contrary, an increase in the pleural fluid level of TGFβ1 and FGFβ] after mechanical pleurodesis with respect to compared group. Although the differences did not reach statistical significance, VEGF, TGFβ1 and FGFβ remain the most interesting parameters for future research. Considering the mechanisms of growth factors action, we conclude that in our study group mechanical pleurodesis might be more efficient in terms of growth factors release, thoracic drainage duration and resulted in a higher symptoms release and in a better quality of life than chemical pleurodesis.

scholarly journals Enthesitis in psoriatic arthritis (Part 3): clinical assessment and management

Rheumatology ◽  
2020 ◽  
Vol 59 (Supplement_1) ◽  
pp. i21-i28 ◽  
Author(s):  
Philip Mease
Keyword(s):  
Quality Of Life ◽  
Physical Examination ◽  
Clinical Assessment ◽  
Janus Kinase ◽  
Clinical Feature ◽  
Phosphodiesterase 4 ◽  
Significant Efficacy ◽  
Synthetic Dmards ◽  
The Impact

Abstract Enthesitis is a common clinical feature of PsA, which is characterized by inflammation at the site of insertion of tendons, ligaments and joint capsule fibres into bone. Enthesitis is relatively unique to the spondyloarthritides, setting this group of diseases apart from other rheumatological conditions. The pathophysiological underpinnings of this clinical domain, and the imaging assessment of it, are described in accompanying articles in this supplement. The focus of this article is on the assessment of enthesitis by physical examination, the impact of enthesitis on function and quality of life, the impact of concomitant FM on clinical assessment, and the evidence for therapy of enthesitis garnered in trials of biologic and targeted synthetic DMARDs. Several physical examination measures of enthesitis have been developed and have proved reliable in assessment of enthesitis. Enthesitis has a significant deleterious impact on function and quality of life. The presence of concomitant FM in ≤20% of patients may result in artefactual worsening of assessment of disease severity and hinder achievement of the goal of low disease activity or remission. Several targeted therapies, which, for example, target the TNF, IL-17, IL-23, phosphodiesterase 4 or Janus kinase pathways, have shown significant efficacy in the treatment of enthesitis, resulting in improvement of function and quality of life for patients with PsA.

scholarly journals More Than Smell—COVID-19 Is Associated With Severe Impairment of Smell, Taste, and Chemesthesis

2020 ◽  
Vol 45 (7) ◽  
pp. 609-622 ◽  
Author(s):  
Valentina Parma ◽  
Kathrin Ohla ◽  
Maria G Veldhuizen ◽  
Masha Y Niv ◽  
Christine E Kelly ◽  
...  
Keyword(s):  
Nasal Obstruction ◽  
Clinical Assessment ◽  
Quantitative Measurements ◽  
Severe Impairment ◽  
Olfactory Ability ◽  
Sensory Neural ◽  
Initial Results ◽  
Smell Loss ◽  
Qualitative Changes

Abstract Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments, such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation, and initial results of a multilingual, international questionnaire to assess self-reported quantity and quality of perception in 3 distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, and 8 others, aged 19–79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste, and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change ±100) revealed a mean reduction of smell (−79.7 ± 28.7, mean ± standard deviation), taste (−69.0 ± 32.6), and chemesthetic (−37.3 ± 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell but also affects taste and chemesthesis. The multimodal impact of COVID-19 and the lack of perceived nasal obstruction suggest that severe acute respiratory syndrome coronavirus strain 2 (SARS-CoV-2) infection may disrupt sensory-neural mechanisms.

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