scholarly journals Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology

2020 ◽  
Vol 8 ◽  
Author(s):  
Zhihui Wu ◽  
Min Tian ◽  
Jinghui Heng ◽  
Jiaming Chen ◽  
Fang Chen ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Milk Production ◽  
Future Perspectives ◽  
Mammary Gland Biology

scholarly journals How to Use Online Tools to Generate New Hypotheses for Mammary Gland Biology Research: A Case Study for Wnt7b

2021 ◽  
Author(s):  
Yorick Bernardus Cornelis van de Grift ◽  
Nika Heijmans ◽  
Renée van Amerongen
Keyword(s):  
Mammary Gland ◽  
In Silico ◽  
Online Tools ◽  
Mammary Gland Biology ◽  
User Friendly ◽  
In Silico Analyses ◽  
Biology Research ◽  
Selection Of

AbstractAn increasing number of ‘-omics’ datasets, generated by labs all across the world, are becoming available. They contain a wealth of data that are largely unexplored. Not every scientist, however, will have access to the required resources and expertise to analyze such data from scratch. Fortunately, a growing number of investigators is dedicating their time and effort to the development of user friendly, online applications that allow researchers to use and investigate these datasets. Here, we will illustrate the usefulness of such an approach. Using regulation of Wnt7b expression as an example, we will highlight a selection of accessible tools and resources that are available to researchers in the area of mammary gland biology. We show how they can be used for in silico analyses of gene regulatory mechanisms, resulting in new hypotheses and providing leads for experimental follow up. We also call out to the mammary gland community to join forces in a coordinated effort to generate and share additional tissue-specific ‘-omics’ datasets and thereby expand the in silico toolbox.

MicroRNA-432 inhibits milk fat synthesis by targeting SCD and LPL in ovine mammary epithelial cells

2021 ◽  
Author(s):  
Zhiyun Hao ◽  
Yuzhu Luo ◽  
Jiqing Wang ◽  
Jon Hickford ◽  
Huitong Zhou ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Epithelial Cells ◽  
Milk Production ◽  
Milk Fat ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Differentially Expressed ◽  
Differentially Expressed Mirnas ◽  
Fat Synthesis ◽  
Milk Fat Synthesis

In our previous studies, microRNA-432 (miR-432) was found to be one of differentially expressed miRNAs in ovine mammary gland between the two breeds of lactating sheep with different milk production...

Sensitivity of mammary secretory cell turnover to protein restriction and re-alimentation during early lactation

1997 ◽  
Vol 1997 ◽  
pp. 130-130
Author(s):  
M.G. Goodwill ◽  
N.S. Jessop ◽  
J.D. Oldham
Keyword(s):  
Cell Proliferation ◽  
Mammary Gland ◽  
Milk Production ◽  
Secretory Cell ◽  
Protein Restriction ◽  
Secretory Cells ◽  
Early Lactation ◽  
Cell Turnover ◽  
Lactational Performance

Milk production depends on both the number and activity of secretory cells within the mammary gland. Our earlier work showed the sensitivity of lactational performance to changes in diet during lactation (Goodwill et al, 1996). This study investigated the influence of protein undernutrition and re-alimentation on secretory cell proliferation and death in the mammary gland of rats during early lactation.

scholarly journals Late gestation supplementation of corn dried distiller’s grains plus solubles to beef cows fed a low-quality forage: III. effects on mammary gland blood flow, colostrum and milk production, and calf body weights

2019 ◽  
Vol 97 (8) ◽  
pp. 3337-3347 ◽  
Author(s):  
Victoria C Kennedy ◽  
James J Gaspers ◽  
Bethany R Mordhorst ◽  
Gerald L Stokka ◽  
Kendall C Swanson ◽  
...  
Keyword(s):  
Blood Flow ◽  
Mammary Gland ◽  
Milk Production ◽  
Beef Cows ◽  
Late Gestation ◽  
Arterial Blood Flow ◽  
Total Blood ◽  
Distiller's Grains ◽  
Arterial Blood ◽  
Term Performance

Abstract Objectives were to investigate the effects of supplementation with corn dried distiller’s grains plus solubles (DDGS) to late gestating beef cows on arterial blood flow to the mammary glands during late gestation and early lactation; colostrum and milk production; dystocia and immunity; and calf BW. Cows were fed a control (CON; n = 15; 5.1% CP; 36.2% ADF) diet consisting of 90% corn stover and 10% corn silage on a dry basis offered ad libitum or CON diet with supplementation of DDGS (0.30% of BW; SUP n = 12). Mammary gland blood flow was assessed on day 245 of gestation. At parturition, maternal and calving parameters were assessed; colostrum and jugular blood was sampled; and dams were weighed. Mammary gland blood flow and milk production was measured on day 44 of lactation. Calves were weighed fortnightly for 8 wk and at weaning. Colostrum production tended to be greater in SUP dams than in CON dams (837 vs. 614 ± 95 g, P = 0.10). Calves of SUP dams were heavier at birth and 24 h (0 h, 43.2 vs. 39.8 ± 1.0 kg, P = 0.02; 24 h, 44.0 vs. 40.4 ± 1.1 kg, P = 0.02). At birth and 24 h, blood pCO2 was greater in calves born to SUP dams (6.82 vs. 6.00 ± 0.41 kPa, P = 0.04). Serum IgG did not differ (P = 0.21) at 24 h. Ipsilateral mammary gland blood flow of SUP cows was greater than CON cows (2.76 vs. 1.76 ± 0.30 L/min; P = 0.03); however, when summed with contralateral, total blood flow was similar (P = 0.33). Hemodynamic measures on day 44 of lactation were similar (P ≥ 0.32). Milk production tended to be increased (13.5 vs. 10.2 ± 1.2 kg/d, P = 0.07) in SUP vs. CON cows. Despite similar BW through 56 d, calves from SUP cows were heavier (P = 0.04) at weaning (309.7 vs. 292.0 ± 6.0 kg). In conclusion, we accept our hypothesis that DDGS supplementation during gestation influenced mammary blood flow, milk production and calf weights. These findings implicate maternal nutrition’s leverage on both nutrient and passive immunity delivery to the calf early in life as well as potential advantages on long-term performance.

A review of bovine growth hormone

1994 ◽  
Vol 74 (2) ◽  
pp. 167-201 ◽  
Author(s):  
Jeanne L. Burton ◽  
Brian W. McBride ◽  
Elliot Block ◽  
David R. Glimm ◽  
John J. Kennelly
Keyword(s):  
Growth Hormone ◽  
Mammary Gland ◽  
Growth Factor ◽  
Dairy Cows ◽  
Milk Production ◽  
Reproductive Efficiency ◽  
Bovine Growth Hormone ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Exogenous Growth

Unprecedented numbers of technical papers, abstracts, and short communications have been published in the past decade regarding the effects of exogenous bovine growth hormone on milk production, health, and reproductive efficiency of treated dairy cows. In well-managed dairy herds, exogenous growth hormone increases milk production without altering normal variability in milk composition. This has held true regardless of dairy breed tested, geographical location studied, or feeding management system used. Also consistent across studies is the rapidity of the galactopoietic effect of administered bovine growth hormone, which arises from altered partitioning and use of post-absorptive nutrients and increased synthetic capacity of the mammary gland. Growth hormone and its associated peptide, insulin-like growth factor-I, are now known to provide chronic lipolytic, diabetogenic, and gluconeogenic signals to target tissues culminating in increased mammary gland availability of glucose and nonesterified fatty acids. Together with yet ill-defined effects on mammary secretory tissue, this homeorhetic control of metabolism elicited by exogenous growth hormone is so efficient that treated cows are not more susceptible to metabolic disorders than untreated cows. However, some studies have reported an increased frequency of mastitis in groups of treated cows. This has been attributed mainly to increased milk volume in the mammary glands of treated cows and no convincing data are available that show decreased mammary gland immunity as a result of growth hormone treatments. On the contrary, an expanding body of evidence implicates growth hormone as a key neuroendocrine factor that is required for immunological competence. Trends of decreased reproductive efficiency in cows treated with growth hormone have also been reported, but available data imply that this is probably an indirect effect via prolonged negative energy balance in cows treated in early lactation rather than a direct negative effect on estrous cycling via altered reproductive hormone profiles. The objectives of the present review are to bring into focus and summarize pertinent biological discoveries regarding the treatment of dairy cows with recombinant bovine growth hormone, and to explore areas where additional growth hormone research is needed or warranted. Key words: Growth hormone, somatotropin, dairy cows, insulin-like growth factor-I

An in vitro approach to ruminant mammary gland biology

1997 ◽  
Vol 15 (1) ◽  
pp. 17-41 ◽  
Author(s):  
E. Matitashvili ◽  
A.J. Bramley ◽  
B. Zavizion
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Biology
Sign in / Sign up

Export Citation Format

Share Document