scholarly journals Nasal Septum Deviation as the Consequence of BMP-Controlled Changes to Cartilage Properties

2021 ◽  
Vol 9 ◽  
Author(s):  
Pranidhi Baddam ◽  
Daniel Young ◽  
Garett Dunsmore ◽  
Chunpeng Nie ◽  
Farah Eaton ◽  
...  
Keyword(s):  
Nasal Septum ◽  
Cartilage Growth ◽  
Knee Oa ◽  
Molecular Abnormalities ◽  
Elastic Cartilage ◽  
Septum Deviation ◽  
Morphogenetic Protein ◽  
Midfacial Hypoplasia ◽  
Nasal Septum Deviation

The nasal septum cartilage is a specialized hyaline cartilage important for normal midfacial growth. Abnormal midfacial growth is associated with midfacial hypoplasia and nasal septum deviation (NSD). However, the underlying genetics and associated functional consequences of these two anomalies are poorly understood. We have previously shown that loss of Bone Morphogenetic Protein 7 (BMP7) from neural crest (BMP7ncko) leads to midfacial hypoplasia and subsequent septum deviation. In this study we elucidate the cellular and molecular abnormalities underlying NSD using comparative gene expression, quantitative proteomics, and immunofluorescence analysis. We show that reduced cartilage growth and septum deviation are associated with acquisition of elastic cartilage markers and share similarities with osteoarthritis (OA) of the knee. The genetic reduction of BMP2 in BMP7ncko mice was sufficient to rescue NSD and suppress elastic cartilage markers. To our knowledge this investigation provides the first genetic example of an in vivo cartilage fate switch showing that this is controlled by the relative balance of BMP2 and BMP7. Cellular and molecular changes similar between NSD and knee OA suggest a related etiology underlying these cartilage abnormalities.

BMP2 Is Required for Postnatal Maintenance of Osteochondral Tissues of the Temporomandibular Joint

Cartilage ◽  
2020 ◽  
pp. 194760352098015
Author(s):  
Mara H. O’Brien ◽  
Eliane H. Dutra ◽  
Shivam Mehta ◽  
Po-Jung Chen ◽  
Sumit Yadav
Keyword(s):  
Age Groups ◽  
Mandibular Condyle ◽  
Bone Morphogenetic Protein 2 ◽  
Matrix Synthesis ◽  
Cartilage Growth ◽  
Chondrocyte Proliferation ◽  
Conditional Deletion ◽  
Morphogenetic Protein

Objective Bone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the in vivo loss of BMP2 in cells expressing aggrecan of the mandibular condyle and knee. Design Three-week-old BMP2 flox/flox- CreER-positive mice and their Cre-negative littermates were treated with tamoxifen and raised until 3 or 6 months. We also investigated the direct effects of BMP2 on chondrocytes in vitro. Cells from the mandibular condyle of mice were treated with recombinant human BMP2 (rhBMP2) or rhNoggin (inhibitor of BMP2 signaling). Results Conditional deletion of BMP2 caused breakage of the cartilage integrity in the mandibular condyle of mice from both age groups, accompanied by a decrease in cartilage thickness, matrix synthesis, mineralization, chondrocyte proliferation, and increased expression of degeneration markers, while the effects at articular cartilage were not significant. In vitro results revealed that rhBMP2 increased chondrocyte proliferation, mineralization, and differentiation, while noggin induced opposite effects. Conclusions In conclusion, BMP2 is essential for postnatal maintenance of the osteochondral tissues of the mandibular condyle.

Comparison of Olfactory Function and Quality of Life With Different Surgical Techniques for Nasal Septum Deviation

2019 ◽  
Vol 30 (2) ◽  
pp. 433-436 ◽  
Author(s):  
Imran Aydoğdu ◽  
Yavuz Atar ◽  
Zeynep Aydoğdu ◽  
Ziya Saltürk ◽  
Enes Ataç ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nasal Septum ◽  
Surgical Techniques ◽  
Olfactory Function ◽  
Septum Deviation ◽  
Nasal Septum Deviation

Morphometric Analysis of Sphenoid Sinus in Patients With Nasal Septum Deviation

2019 ◽  
Vol 30 (5) ◽  
pp. 1605-1608
Author(s):  
Israfil Orhan ◽  
Tugrul Ormeci ◽  
Nagihan Bilal ◽  
Saime Sagiroglu ◽  
Adem Doganer
Keyword(s):  
Morphometric Analysis ◽  
Nasal Septum ◽  
Sphenoid Sinus ◽  
Septum Deviation ◽  
Nasal Septum Deviation

scholarly journals A false nasal septum deviation

2013 ◽  
Vol 130 (6) ◽  
pp. 359-361
Author(s):  
C.-A. Righini ◽  
I. Atallah ◽  
E. Reyt
Keyword(s):  
Nasal Septum ◽  
Septum Deviation ◽  
Nasal Septum Deviation

Evaluation of inferior turbinate hypertrophy in patients with congenital and traumatic nasal septum deviation

2012 ◽  
Vol 126 (8) ◽  
pp. 784-788 ◽  
Author(s):  
A Y Korkut ◽  
F Islim ◽  
S Gulseven Ciftci ◽  
R Dogan ◽  
O Gedikli ◽  
...  
Keyword(s):  
Nasal Septum ◽  
Group Versus ◽  
Inferior Turbinate ◽  
Septal Deviation ◽  
Septum Deviation ◽  
Turbinate Hypertrophy ◽  
Nasal Septum Deviation ◽  
Traumatic Group ◽  
The Difference ◽  
Inferior Turbinate Hypertrophy

AbstractObjective:To compare mucosal and bony measurements in patients with congenital and traumatic nasal septum deviation and compensatory inferior turbinate hypertrophy.Methods:The study examined 50 patients with nasal septum deviation (25 congenital and 25 traumatic) and compensatory inferior turbinate hypertrophy in the contralateral nasal cavity, confirmed by computed tomography.Results:The study compared inferior turbinate measurements on the concave and convex sides of the septum, in the congenital and traumatic groups. Measurements comprised: the shortest distance from the median line to the medial border of the conchal bone; the distances from the most medial part of the conchal mucosa and the conchal bone to the lateral line; the projection angle of the inferior turbinate; and the widest parts of the whole inferior turbinate and the inferior turbinate conchal bone. The differences between the concave and convex side measurements were compared in the congenital group versus the traumatic group; for three measurements, the difference between these two groups was statistically significant (p < 0.05).Conclusion:The present study findings suggest that the conchal bone has a marked influence on nasal patency in patients with congenital septal deviation. These findings supported the decision to excise the inferior turbinate bone at the time of septoplasty, especially when treating congenital septal deviation.

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