scholarly journals Validation of the Relationship Between Iris Color and Uveal Melanoma Using Artificial Intelligence With Multiple Paths in a Large Chinese Population

2021 ◽  
Vol 9 ◽  
Author(s):  
Haihan Zhang ◽  
Yueming Liu ◽  
Kai Zhang ◽  
Shiqi Hui ◽  
Yu Feng ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Chinese Population ◽  
Anterior Segment ◽  
Learning Methods ◽  
Predisposing Factor ◽  
Iris Color ◽  
Multiple Paths ◽  
Color Spectrum ◽  
Classification Probability ◽  
High Consistency

Previous studies have shown that light iris color is a predisposing factor for the development of uveal melanoma (UM) in a population of Caucasian ancestry. However, in all these studies, a remarkably low percentage of patients have brown eyes, so we applied deep learning methods to investigate the correlation between iris color and the prevalence of UM in the Chinese population. All anterior segment photos were automatically segmented with U-NET, and only the iris regions were retained. Then the iris was analyzed with machine learning methods (random forests and convolutional neural networks) to obtain the corresponding iris color spectra (classification probability). We obtained satisfactory segmentation results with high consistency with those from experts. The iris color spectrum is consistent with the raters’ view, but there is no significant correlation with UM incidence.

scholarly journals Uveal Melanoma and Secondary Angle-Closure Crisis: A Case Report and Literature Review

2021 ◽  
pp. 476-480
Author(s):  
Tung Thanh Hoang ◽  
Tuan Anh Hoang ◽  
Peter McCluskey ◽  
John Grigg
Keyword(s):  
Retinal Detachment ◽  
Uveal Melanoma ◽  
Vision Loss ◽  
Serous Retinal Detachment ◽  
Anterior Segment ◽  
Angle Closure ◽  
Large Tumor ◽  
Tumor Mass ◽  
Healthy Female ◽  
Life Threatening

A 66-years-old Vietnamese healthy female patient presented with prolonged severe right ocular pain and complete vision loss in that eye. Anterior segment assessment including gonioscopy identified angle-closure configuration. A suspected ciliary body melanoma was seen through the pupil. Posterior segment examination revealed a large tumor mass and 360° retinal detachment (kissing configuration). An ultrasound examination was consistent with a uveal tumor. The painful, blind right eye with a tumor mass was enucleated. Histopathology confirmed a type A uveal spindle cell melanoma associated with total serous retinal detachment without evidence of tumor necrosis, epithelioid cells, scleral, or optic nerve infiltration. There was no evidence of metastasis after 1-year of follow-up. It is critically important to differentiate primary and secondary angle closure, especially in cases with life-threatening ocular malignancy as uveal melanoma.

Prophylactic Use of Bevacizumab to Avoid Anterior Segment Neovascularization Following Proton Therapy for Uveal Melanoma

2014 ◽  
Vol 158 (4) ◽  
pp. 693-701.e2 ◽  
Author(s):  
Irmela Mantel ◽  
Ann Schalenbourg ◽  
Ciara Bergin ◽  
Aleksandra Petrovic ◽  
Damien C. Weber ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Proton Therapy ◽  
Anterior Segment ◽  
Prophylactic Use

Positive Interaction Between Light Iris Color and Ultraviolet Radiation in Relation to the Risk of Uveal Melanoma

Ophthalmology ◽  
2009 ◽  
Vol 116 (2) ◽  
pp. 340-348 ◽  
Author(s):  
Andrea Schmidt-Pokrzywniak ◽  
Karl-Heinz Jöckel ◽  
Norbert Bornfeld ◽  
Wolfgang Sauerwein ◽  
Andreas Stang
Keyword(s):  
Ultraviolet Radiation ◽  
Uveal Melanoma ◽  
Positive Interaction ◽  
Iris Color

scholarly journals Uveal Melanoma Biopsy. A Review

2020 ◽  
Vol 76 (6) ◽  
pp. 247-252
Author(s):  
Štěpán Rusňák ◽  
Lenka Hecová ◽  
Zdeněk Kasl ◽  
Markéta Sobotová ◽  
Lukáš Hauer
Keyword(s):  
Uveal Melanoma ◽  
Tissue Sample ◽  
Anterior Segment ◽  
Punch Biopsy ◽  
Sample Collection ◽  
Surgical Biopsy ◽  
Diagnostic Uncertainty ◽  
Intraocular Tumors ◽  
Tumor Dissemination ◽  
Biopsy Punch

In intraocular tumors, diagnosis is usually based on clinical examination and imaging without the need for invasive surgery or tissue sampling. The diagnosis can be confirmed by biopsy, however, in the case of intraocular malignancy, the biopsy is considered controversial. Due to the development of uveal melanoma cytogenetic prognostics and the progression in generalised uveal melanoma treatment, intraocular melanoma biopsy is becoming increasingly important. Diagnostic biopsy of intraocular tumors is indicated in cases of diagnostic uncertainty for findings with conflicting non-invasive test results and for small melanocyte lesions. Tumor prognostic biopsy is performed to obtain a tissue sample for tumor cytogenetic testing, which can help to determine the prognosis and specific metastatic risk of the patient. For anterior segment tumors, anterior chamber fluid sampling, thin-needle iris biopsy, punch biopsy, surgical biopsy or biopsy using vitrectomy may be used. For posterior segment tumors, procedures include transscleral or transretinal thin-needle biopsy, vitrectomy-assisted biopsy, punch biopsy, endoresection or transscleral exoresection. Complications of intraocular melanoma biopsy include too small or non-valuable sample collection, intra-tumoral heterogeneity, intra-ocular trauma and induction of intraocular or extraocular tumor dissemination.

Anterior segment sparing to reduce charged particle radiotherapy complications in uveal melanoma

1997 ◽  
Vol 39 (5) ◽  
pp. 997-1010 ◽  
Author(s):  
Inder K. Daftari ◽  
Devron H. Char ◽  
Lynn J. Verhey ◽  
Joseph R. Castro ◽  
Paula L. Petti ◽  
...  
Keyword(s):  
Charged Particle ◽  
Uveal Melanoma ◽  
Anterior Segment ◽  
Particle Radiotherapy

scholarly journals Dental Caries Experience in the Deciduous Dentition of Rural Guatemalan Children Ages 6 Months to 7 Years

1976 ◽  
Vol 55 (6) ◽  
pp. 951-957 ◽  
Author(s):  
Peter F. Infante ◽  
George M. Gillespie
Keyword(s):  
Dental Caries ◽  
Anterior Segment ◽  
Caries Experience ◽  
Caries Prevalence ◽  
Enamel Hypoplasia ◽  
Deciduous Dentition ◽  
Predisposing Factor ◽  
White Children ◽  
Linear Enamel Hypoplasia ◽  
Repeated Observation

A study of 528 Guatemalan children indicated that caries prevalence in the deciduous dentition was twice as great as but in the permanent dentition was similar to that for US white children. This is a repeated observation for children of some preindustrial societies. Caries experience was significantly greater in boys. Until 4 years of age, caries attack was greater in the anterior segment of the oral cavity; linear enamel hypoplasia was a predisposing factor.

scholarly journals Chromosome 3 and 8q aberrations in Uveal Melanoma show greater impact on survival in patients with light iris versus dark iris color

Ophthalmology ◽  
2021 ◽  
Author(s):  
Annemijn P.A. Wierenga ◽  
Niels J. Brouwer ◽  
Maria Chiara Gelmi ◽  
Robert M. Verdijk ◽  
Marc-Henri Stern ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Chromosome 3 ◽  
Iris Color ◽  
Impact On Survival
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