scholarly journals The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection

2021 ◽  
Vol 11 ◽  
Author(s):  
Teng Li ◽  
Lijun Cui ◽  
Xiaoyan Xu ◽  
Haixia Zhang ◽  
Yuzhu Jiang ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnancy Outcomes ◽  
Neutralizing Antibody ◽  
Mechanism Analysis ◽  
Abnormal Pregnancy ◽  
Inhibitory Molecule ◽  
Pregnant Mice ◽  
Ifn Γ ◽  
Toxoplasma Gondii Infection

Vertical transmission of Toxoplasma gondii (T. gondii) infection during gestation can result in severe complications such as abortion, congenital malformation, fetal teratogenesis, etc. Immune inhibitory molecule Tim-3 was discovered to be expressed on some decidual immune cells and participates in the maintenance of maternal-fetal tolerance. Dysregulation of Tim-3 expression on decidual NK (dNK) cells was observed in several cases of pregnancy complications, whereas the role of Tim-3 on dNK cells during T. gondii infection remains unclear. In the present study, T. gondii infected Tim-3-/- pregnant mice, and anti-Tim-3 neutralizing antibody treated and infected human dNK cells were successfully established to explore the role of Tim-3 in dysfunction of dNK cells during abnormal pregnancy. Our results illustrated that Tim-3-/- pregnant mice displayed more worse pregnancy outcomes with T. gondii infection compared to infected WT pregnant mice. Also, it demonstrated that Tim-3 expression on dNK cells was significantly down-regulated following T. gondii infection. Data suggested a remarkable activation of dNK cells in Tim-3-/- mice and anti-Tim-3 neutralizing antibody treated and infected groups, with higher ratios of activating receptor NKG2D to inhibitory receptor NKG2A or KIR2DL4, IFN-γ/IL-10, and increased granule production compared with that of the infected group. Mechanism analysis proved that T. gondii-induced Tim-3 down-regulation significantly activated the phosphatidylinositol-3-kinase (PI3K)-AKT and JAK-STAT signaling pathway, by which the GranzymeB, Perforin, IFN-γ, and IL-10 production were further up-regulated. Our research demonstrated that the decrease of Tim-3 on dNK cells caused by T. gondii infection further led to dNK cells function disorder, which finally contributed to the development of abnormal pregnancy outcomes.

scholarly journals LILRB4 Decrease on uDCs Exacerbate Abnormal Pregnancy Outcomes Following Toxoplasma gondii Infection

2018 ◽  
Vol 9 ◽  
Author(s):  
Shaowei Zhan ◽  
Jing Zheng ◽  
Haixia Zhang ◽  
Mingdong Zhao ◽  
Xianbing Liu ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnancy Outcomes ◽  
Abnormal Pregnancy ◽  
Toxoplasma Gondii Infection

The Role of Decidual PD-1+ Treg Cells in Adverse Pregnancy Outcomes due to Toxoplasma gondii Infection

Inflammation ◽  
2019 ◽  
Vol 42 (6) ◽  
pp. 2119-2128 ◽  
Author(s):  
Haixia Zhang ◽  
Lijun Cui ◽  
Liqin Ren ◽  
Xianbing Liu ◽  
Yuzhu Jiang ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnancy Outcomes ◽  
Treg Cells ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy ◽  
Toxoplasma Gondii Infection

scholarly journals Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

2005 ◽  
Vol 73 (1) ◽  
pp. 617-621 ◽  
Author(s):  
Michelle N. Kelly ◽  
Jay K. Kolls ◽  
Kyle Happel ◽  
Joseph D. Schwartzman ◽  
Paul Schwarzenberger ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Adaptive Immunity ◽  
Protective Immunity ◽  
Polymorphonuclear Leukocytes ◽  
Early Infection ◽  
Interleukin 17 ◽  
Toxoplasma Gondii Infection ◽  
Knockout Animals

ABSTRACT We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

Is Toxoplasma gondii Infection a Cause or a Coincidence in an Adolescent with Psychosis?

2020 ◽  
Author(s):  
Hüsniye Yucel ◽  
Burak Acikel ◽  
F Nur Öz ◽  
Saliha Senel
Keyword(s):  
Toxoplasma Gondii ◽  
Psychiatric Symptoms ◽  
Current Level ◽  
Neuropsychiatric Diseases ◽  
New Knowledge ◽  
Young Adolescent Girl ◽  
Toxoplasma Gondii Infection ◽  
Psychiatric Problems ◽  
Immunocompetent Patients

AbstractAlthough presumed to be relatively harmless in immunocompetent patients, toxoplasmosis has been linked to several psychiatric problems such as schizophrenia, bipolar disorder, and suicidal/aggressive behaviors. We describe an 11-year-old young adolescent girl with psychoses who was ultimately diagnosed with toxoplasmosis. It is an unusual presentation of Toxoplasma gondii infection that adds new knowledge to the current level of literature about the substantial role of Toxoplasma gondii in the etiology of neuropsychiatric diseases. We propose that screening for toxoplasmosis is needed besides other etiologies in differential diagnosis of psychiatric symptoms particularly in endemic areas.

scholarly journals Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection

2019 ◽  
Vol 51 (12) ◽  
pp. 1-10 ◽  
Author(s):  
Miwa Sasai ◽  
Masahiro Yamamoto
Keyword(s):  
Immune Response ◽  
Toxoplasma Gondii ◽  
Immune Responses ◽  
Parasitophorous Vacuole ◽  
Interferon Γ ◽  
Protective Role ◽  
Ifn Γ ◽  
Acquired Immune Responses ◽  
Toxoplasma Gondii Infection ◽  
Antimicrobial Immunity

AbstractHosts have been fighting pathogens throughout the evolution of all infectious diseases. Toxoplasma gondii is one of the most common infectious agents in humans but causes only opportunistic infection in healthy individuals. Similar to antimicrobial immunity against other organisms, the immune response against T. gondii activates innate immunity and in turn induces acquired immune responses. After activation of acquired immunity, host immune cells robustly produce the proinflammatory cytokine interferon-γ (IFN-γ), which activates a set of IFN-γ-inducible proteins, including GTPases. IFN-inducible GTPases are essential for cell-autonomous immunity and are specialized for effective clearance and growth inhibition of T. gondii by accumulating in parasitophorous vacuole membranes. Recent studies suggest that the cell-autonomous immune response plays a protective role in host defense against not only T. gondii but also various intracellular bacteria. Moreover, the negative regulatory mechanisms of such strong immune responses are also important for host survival after infection. In this review, we will discuss in detail recent advances in the understanding of host defenses against T. gondii and the roles played by cell-autonomous immune responses.

scholarly journals A Meta Analysis on Risks of Adverse Pregnancy Outcomes in Toxoplasma gondii Infection

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97775 ◽  
Author(s):  
Xue-Lan Li ◽  
Hai-Xia Wei ◽  
Hao Zhang ◽  
Hong-Juan Peng ◽  
David S. Lindsay
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Pregnancy ◽  
Toxoplasma Gondii Infection
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