scholarly journals Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

2005 ◽  
Vol 73 (1) ◽  
pp. 617-621 ◽  
Author(s):  
Michelle N. Kelly ◽  
Jay K. Kolls ◽  
Kyle Happel ◽  
Joseph D. Schwartzman ◽  
Paul Schwarzenberger ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Adaptive Immunity ◽  
Protective Immunity ◽  
Polymorphonuclear Leukocytes ◽  
Early Infection ◽  
Interleukin 17 ◽  
Toxoplasma Gondii Infection ◽  
Knockout Animals

ABSTRACT We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

Is Toxoplasma gondii Infection a Cause or a Coincidence in an Adolescent with Psychosis?

2020 ◽  
Author(s):  
Hüsniye Yucel ◽  
Burak Acikel ◽  
F Nur Öz ◽  
Saliha Senel
Keyword(s):  
Toxoplasma Gondii ◽  
Psychiatric Symptoms ◽  
Current Level ◽  
Neuropsychiatric Diseases ◽  
New Knowledge ◽  
Young Adolescent Girl ◽  
Toxoplasma Gondii Infection ◽  
Psychiatric Problems ◽  
Immunocompetent Patients

AbstractAlthough presumed to be relatively harmless in immunocompetent patients, toxoplasmosis has been linked to several psychiatric problems such as schizophrenia, bipolar disorder, and suicidal/aggressive behaviors. We describe an 11-year-old young adolescent girl with psychoses who was ultimately diagnosed with toxoplasmosis. It is an unusual presentation of Toxoplasma gondii infection that adds new knowledge to the current level of literature about the substantial role of Toxoplasma gondii in the etiology of neuropsychiatric diseases. We propose that screening for toxoplasmosis is needed besides other etiologies in differential diagnosis of psychiatric symptoms particularly in endemic areas.

scholarly journals Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Samantha J. Batista ◽  
Katherine M. Still ◽  
David Johanson ◽  
Jeremy A. Thompson ◽  
Carleigh A. OʼBrien ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Protective Immunity ◽  
Toxoplasma Gondii Infection

scholarly journals Impact of Toxoplasma gondii infection on human health

2021 ◽  
Vol 8 (1) ◽  
pp. 1093-1099
Author(s):  
Taibur Rahman ◽  
Jerin E Gulshan ◽  
Atiqur Rahman
Keyword(s):  
Toxoplasma Gondii ◽  
Clinical Symptoms ◽  
Organ Transplant ◽  
Human Diseases ◽  
Immunodeficiency Virus ◽  
Life Threatening ◽  
Toxoplasma Gondii Infection ◽  
Immunocompetent Adults ◽  
Persistence Behavior

Toxoplasmosis is one of the most prevalent infectious disease around the globe and it is caused by the parasite named Toxoplasma gondii. Infections normally lead to asymptomatic parasite persistence in immunocompetent warm-blooded hosts, including up to 30-50% of humans. However, T. gondii infection has also a major medical concern and can lead to life-threatening diseases, after reactivation in immunocompromized individuals, particularly in patients with human immunodeficiency virus/cancer or organ transplant recipients, after vertical transmission to fetuses of pregnant women and by inducing recurrent uveitis in immunocompetent adults. More importantly, T. gondii undergoes stage conversion from its fast-replicating tachyzoite to slow replicating dormant bradyzoite preferentially in the brain and skeletal muscles, and lesser extent in the eye, liver, kidney and lung which enable the parasite to persist for the whole life of an individual. Due to the persistence behavior of the parasite in different parts of human body, T. gondii can develop multiple human diseases with severe clinical symptoms. In this study, we have summarized the association of T. gondii in multiple human diseases for instance Encephalitis, Parkinson’s disease, Schizophrenia, Heart disease, Ocular Toxoplasmosis, Congenital abnormalities, Cancer and Diabetes. This highlights the potential role of T. gondii in developing fatal diseases, particularly in immunocompromised individuals despite having asymptomatic nature of the parasite. Bioresearch Commu. 8(1): 1093-1099, 2022 (January)

scholarly journals The Role of Tim-3 on dNK Cells Dysfunction During Abnormal Pregnancy With Toxoplasma gondii Infection

2021 ◽  
Vol 11 ◽  
Author(s):  
Teng Li ◽  
Lijun Cui ◽  
Xiaoyan Xu ◽  
Haixia Zhang ◽  
Yuzhu Jiang ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnancy Outcomes ◽  
Neutralizing Antibody ◽  
Mechanism Analysis ◽  
Abnormal Pregnancy ◽  
Inhibitory Molecule ◽  
Pregnant Mice ◽  
Ifn Γ ◽  
Toxoplasma Gondii Infection

Vertical transmission of Toxoplasma gondii (T. gondii) infection during gestation can result in severe complications such as abortion, congenital malformation, fetal teratogenesis, etc. Immune inhibitory molecule Tim-3 was discovered to be expressed on some decidual immune cells and participates in the maintenance of maternal-fetal tolerance. Dysregulation of Tim-3 expression on decidual NK (dNK) cells was observed in several cases of pregnancy complications, whereas the role of Tim-3 on dNK cells during T. gondii infection remains unclear. In the present study, T. gondii infected Tim-3-/- pregnant mice, and anti-Tim-3 neutralizing antibody treated and infected human dNK cells were successfully established to explore the role of Tim-3 in dysfunction of dNK cells during abnormal pregnancy. Our results illustrated that Tim-3-/- pregnant mice displayed more worse pregnancy outcomes with T. gondii infection compared to infected WT pregnant mice. Also, it demonstrated that Tim-3 expression on dNK cells was significantly down-regulated following T. gondii infection. Data suggested a remarkable activation of dNK cells in Tim-3-/- mice and anti-Tim-3 neutralizing antibody treated and infected groups, with higher ratios of activating receptor NKG2D to inhibitory receptor NKG2A or KIR2DL4, IFN-γ/IL-10, and increased granule production compared with that of the infected group. Mechanism analysis proved that T. gondii-induced Tim-3 down-regulation significantly activated the phosphatidylinositol-3-kinase (PI3K)-AKT and JAK-STAT signaling pathway, by which the GranzymeB, Perforin, IFN-γ, and IL-10 production were further up-regulated. Our research demonstrated that the decrease of Tim-3 on dNK cells caused by T. gondii infection further led to dNK cells function disorder, which finally contributed to the development of abnormal pregnancy outcomes.

scholarly journals Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection

2019 ◽  
Vol 10 (3) ◽  
Author(s):  
Tanmay Majumdar ◽  
Shagun Sharma ◽  
Manmohan Kumar ◽  
Md. Arafat Hussain ◽  
Namita Chauhan ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Kynurenine Pathway ◽  
Toxoplasma Gondii Infection ◽  
Parasitic Role
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