scholarly journals Influence of Gender in Advanced Heart Failure Therapies and Outcome Following Transplantation

2021 ◽  
Vol 8 ◽  
Author(s):  
María Dolores García-Cosío ◽  
Francisco González-Vilchez ◽  
Raquel López-Vilella ◽  
Eduardo Barge-Caballero ◽  
Manuel Gómez Bueno ◽  
...  
Keyword(s):  
Heart Failure ◽  
Sex Differences ◽  
Heart Transplantation ◽  
Heart Transplant ◽  
Advanced Heart Failure ◽  
Waiting List ◽  
Ventricular Assist Devices ◽  
Long Term Results ◽  
Current Evidence ◽  
Men And Women

Biological differences between males and females change the course of different diseases and affect therapeutic measures' responses. Heart failure is not an exception to these differences. Women account for a minority of patients on the waiting list for heart transplantation or other advanced heart failure therapies. The reason for this under-representation is unknown. Men have a worse cardiovascular risk profile and suffer more often from ischemic heart disease. Conversely, transplanted women are younger and more frequently have non-ischemic cardiac disorders. Women's poorer survival on the waiting list for heart transplantation has been previously described, but this trend has been corrected in recent years. The use of ventricular assist devices in women is progressively increasing, with comparable results than in men. The indication rate for a heart transplant in women (number of women on the waiting list for millions of habitants) has remained unchanged over the past 25 years. Long-term results of heart transplants are equal for both men and women. We have analyzed the data of a national registry of heart transplant patients to look for possible future directions for a more in-depth study of sex differences in this area. We have analyzed 1-year outcomes of heart transplant recipients. We found similar results in men and women and no sex-related interactions with any of the factors related to survival or differences in death causes between men and women. We should keep trying to approach sex differences in prospective studies to confirm if they deserve a different approach, which is not supported by current evidence.

scholarly journals Impact of Heart Transplantation on Cheyne-Stokes Respiration in a Child

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Suhail Al-Saleh ◽  
Paul F. Kantor ◽  
Indra Narang
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Dilated Cardiomyopathy ◽  
Heart Transplant ◽  
Cardiac Transplantation ◽  
Sleep Disordered Breathing ◽  
Pediatric Population ◽  
Severe Heart Failure ◽  
Advanced Heart Failure ◽  
Caucasian Male

Sleep disordered breathing is well described in adults with heart failure but not in pediatric population. We describe a 13-year-old Caucasian male with severe heart failure related to dilated cardiomyopathy who demonstrated polysomnographic features of Cheyne-Stokes respiration, which completely resolved following cardiac transplantation. Cheyne-Stokes respiration in children with advanced heart failure and its resolution after heart transplant can be observed similar to adults.

scholarly journals Mechanical Circulatory Support in Advanced Heart Failure

2021 ◽  
pp. 263246362110327
Author(s):  
Sonali Arora ◽  
Auras R. Atreya
Keyword(s):  
Heart Failure ◽  
Cardiogenic Shock ◽  
Heart Transplantation ◽  
Medical Therapy ◽  
Mechanical Circulatory Support ◽  
Advanced Heart Failure ◽  
Ventricular Assist Devices ◽  
Circulatory Support ◽  
Ventricular Assist ◽  
Advanced Therapies

Advanced heart failure (HF) with persistent and progressive clinical decline despite maximal medical therapy portends a high mortality in the absence of advanced therapies, such as ventricular assist devices or heart transplantation. A subset of these advanced HF patients deteriorates into refractory cardiogenic shock, that is challenging to manage with vasoactive agents alone. Temporary mechanical circulatory support (MCS) device options have evolved over the years and provide a viable option to rescue and rest the myocardium of patients in cardiogenic shock. The goal of such therapy is to serve as bridge to recovery, or more often, a bridge to durable advanced therapies. For those patients with progressive advanced HF despite extensive medical therapy, durable MCS devices (ventricular assist devices) are available when heart transplantation is not feasible. In this article, we review currently available temporary and durable MCS devices, with a focus on their hemodynamic profiles, to inform optimal device selection for patients with advanced HF.

scholarly journals Use of Ventricular Assist Devices and Heart Transplantation for Advanced Heart Failure

2019 ◽  
Vol 124 (11) ◽  
pp. 1658-1678 ◽  
Author(s):  
Leslie Miller ◽  
Emma Birks ◽  
Maya Guglin ◽  
Harveen Lamba ◽  
O.H. Frazier
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Advanced Heart Failure ◽  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Assist Devices

scholarly journals Aortic intervention guided by contrast-enhanced transoesophageal ultrasound whist waiting for cardiac transplantation: a case report

2020 ◽  
Author(s):  
Mireya Castro Verdes ◽  
Xun Yuan ◽  
Wei Li ◽  
Roxy Senior ◽  
Christoph A Nienaber
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Left Ventricular ◽  
Advanced Heart Failure ◽  
Ventricular Assist Devices ◽  
Left Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Contrast Enhanced ◽  
Left Ventricular Assist ◽  
Aortic Interventions

Abstract Background  Aortic complications can happen during left ventricular assist devices (LVADs) insertion and its treatment remains challenging. Percutaneous aortic interventions can be an alternative to surgery in such high-risk cases. Case summary  We present a patient with idiopatic dilated cardiomyopathy and advanced heart failure requiring LVAD insertion as a bridge to transplant, who developed an aortic pseudoaneurysm below the anastomosis of the LVAD tube. He was successfully treated with percutaneous coiling under contrast-enhanced transoesophageal echocardiography (TOE) guidance, reaching destination therapy (heart transplantation) a year later. Discussion  Left ventricular assist devices provide haemodynamic support for patients with advanced heart failure waiting for heart transplantation. Although uncommon, aortic complications can happen as a result of LVAD insertion and be life-threatening. Percutaneous aortic interventions can be performed in such cases to promote thrombosis and remodelling of false lumen or aneurysmatic spaces, hence potentially reducing the risk of sudden death. Contrast-enhanced TOE can be easily and safely used to monitor the intervention in order to improve anatomic definition, guide positioning of wires and catheters and assess early results.

scholarly journals Heart Transplantation in Adriamycin-Associated Cardiomyopathy in the Contemporary Era of Advanced Heart Failure Therapies

2021 ◽  
Vol 3 (2) ◽  
pp. 294-301
Author(s):  
Bhavadharini Ramu ◽  
Maria Masotti ◽  
Ryan J. Tedford ◽  
Rebecca J. Cogswell
Keyword(s):  
Heart Failure ◽  
Heart Transplantation ◽  
Advanced Heart Failure
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