Corrigendum: Imaging Protocol, Feasibility, and Reproducibility of Cardiovascular Phenotyping in a Large Tri-Ethnic Population-Based Study of Older People: The Southall and Brent Revisited (SABRE) Study

Background: People of South Asian and African Caribbean ethnicities living in UK have a high risk of cardiometabolic disease. Limited data exist regarding detailed cardiometabolic phenotyping in this population. Methods enabling this are widely available, but the practical aspects of undertaking such studies in large and diverse samples are seldom reported. Methods: The Southall and Brent Revisited (SABRE) study is the UK largest tri-ethnic longitudinal cohort. Over 1400 surviving participants (58-85 y) attended the 2nd study-visit (2008-2011) during which comprehensive cardiovascular phenotyping, including 3D-echocardiography (3D-speckle-tracking (3D-STE)), computed tomography, coronary artery calcium scoring, pulse-wave velocity, central blood pressure, carotid artery ultrasound and retinal imaging were performed. We describe the methods used with the aim of providing a guide to their feasibility and reproducibility in a large tri-ethnic population-based study of older people. Results: Conventional echocardiography and all vascular measurements showed high feasibility (>90% analyzable of clinic-attendees). 3DE and 3D-STE were less feasible in this age group (76% 3DE acquisition feasibility and 38% 3D-STE feasibility of clinic-attendees). Intra- and inter-observer variabilities were excellent for most of conventional and advanced echocardiographic measures. The test-retest reproducibility was good-excellent and fair-good for conventional and advanced echocardiographic measures, respectively, but lower than when re-reading the same images. All vascular measures demonstrated excellent or fair-good reproducibility. Conclusions: Detailed cardiovascular phenotyping is feasible and reproducible in an ethnically diverse population. The data collected will lead to a better understanding of why people of South Asian and African Caribbean ancestry are at elevated risk of cardiometabolic diseases.

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ATRIAL FIBRILLATION, COGNITIVE DECLINE, AND DEMENTIA AMONG OLDER PEOPLE: A LONGITUDINAL POPULATION-BASED STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2017.06.082 ◽

2017 ◽

Vol 13 (7) ◽

pp. P238

Author(s):

Mozhu Ding ◽

Laura Fratiglioni ◽

Kristina Johnell ◽

Alessandra Marengoni ◽

Petter Ljungman ◽

...

Keyword(s):

Atrial Fibrillation ◽

Older People ◽

Cognitive Decline ◽

Population Based ◽

Population Based Study

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Re: Anticholinergic Drug Use, Serum Anticholinergic Activity, and Adverse Drug Events among Older People: A Population-Based Study

The Journal of Urology ◽

10.1016/j.juro.2014.05.059 ◽

2014 ◽

Vol 192 (2) ◽

pp. 490-491

Author(s):

Tomas L. Griebling

Keyword(s):

Drug Use ◽

Older People ◽

Adverse Drug Events ◽

Anticholinergic Drug ◽

Population Based ◽

Population Based Study ◽

Anticholinergic Activity

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Self-Reported Vision Impairment and Frailty among Older People with Low Cognitive Performance in Central Africa: EPIDEMCA Population-Based Study

Dementia and Geriatric Cognitive Disorders ◽

10.1159/000518601 ◽

2021 ◽

pp. 1-7

Author(s):

Antoine Gbessemehlan ◽

Gilles Kehoua ◽

Catherine Helmer ◽

Cécile Delcourt ◽

Achille Tchalla ◽

...

Keyword(s):

Older People ◽

Cognitive Performance ◽

Odds Ratio ◽

Adjusted Odds Ratio ◽

Central Africa ◽

Population Based ◽

Vision Impairment ◽

Sub Saharan Africa ◽

Population Based Study ◽

The Impact

Introduction: Very little is known about the impact of vision impairment (VI) on physical health in late-life in sub-Saharan Africa populations, whereas many older people experience it. We investigated the association between self-reported VI and frailty in Central African older people with low cognitive performance. Methods: It was cross-sectional analysis of data from the Epidemiology of Dementia in Central Africa (EPIDEMCA) population-based study. After screening for cognitive impairment, older people with low cognitive performance were selected. Frailty was assessed using the Study of Osteoporotic Fracture index. Participants who met one of the 3 parameters assessed (unintentional weight loss, inability to do 5 chair stands, and low energy level) were considered as pre-frail, and those who met 2 or more parameters were considered as frail. VI was self-reported. Associations were investigated using multinomial logistic regression models. Results: Out of 2,002 older people enrolled in EPIDEMCA, 775 (38.7%) had low cognitive performance on the screening test. Of them, 514 participants (sex ratio: 0.25) had available data on VI and frailty and were included in the analyses. In total, 360 (70%) self-reported VI. Prevalence of frailty was estimated at 64.9% [95% confidence interval: 60.9%–69.1%] and 23.7% [95% CI: 20.1%–27.4%] for pre-frailty. After full adjustment, self-reported VI was associated with frailty (adjusted odds ratio = 2.2; 95% CI: 1.1–4.3) but not with pre-frailty (adjusted odds ratio = 1.8; 95% CI: 0.9–3.7). Conclusion: In Central African older people with low cognitive performance, those who self-reported VI were more likely to experience frailty. Our findings suggest that greater attention should be devoted to VI among this vulnerable population in order to identify early frailty onset and provide adequate care management.

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