scholarly journals Atherogenic Index of Plasma and Coronary Artery Disease in the Adult Population: A Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Jing Wu ◽  
Qiang Zhou ◽  
Zhouxia Wei ◽  
Jinying Wei ◽  
Meizi Cui
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Observational Studies ◽  
Meta Analysis ◽  
Adult Population ◽  
Atherogenic Index ◽  
Current Evidence ◽  
Atherogenic Index Of Plasma ◽  
Adjusted Risk ◽  
Artery Disease

Background: The atherogenic index of plasma (AIP), which is the logarithm of the ratio between the triglyceride and high-density lipoprotein cholesterol (TG/HDL-C) concentrations in molar units, is correlated with the burden of atherosclerosis. This study aimed to evaluate the association between the AIP and coronary artery disease (CAD) in the adult population by performing a meta-analysis.Methods: Observational studies relevant for this meta-analysis were identified by searching the PubMed, Embase, and Web of Science databases. Only studies using multivariate analysis were considered. A random-effects model, which incorporates potential intra-study heterogeneity, was applied to combine the results.Results: Ten observational studies were included. In studies with the AIP analyzed as a continuous variable, a higher AIP was associated with a higher odds of CAD (adjusted risk ratio [RR] per 1-standard deviation [SD] increment of AIP: 2.10, 95% confidence interval [CI]: 1.51–2.93, P < 0.001, I2 = 90%). Further analysis of studies with the AIP analyzed as a categorical variable showed a higher odds of CAD (adjusted RR: 2.35, 95% CI: 1.88–2.93, P < 0.001, I2 = 37%) in the participants with the highest versus the lowest AIP value. Subgroup analyses demonstrated consistent results in asymptomatic and symptomatic populations as well as in male and female participants (all between-group P values > 0.05).Discussion: Current evidence, mostly from cross-sectional studies, suggests that a higher AIP value may be independently associated with CAD in the adult population.

scholarly journals RANTES Gene G-403A Polymorphism and Coronary Artery Disease: A Meta Analysis of Observational Studies

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e47211 ◽  
Author(s):  
Jun Liu ◽  
Yan-Jun Jia ◽  
Xiao-Lin Li ◽  
Rui-Xa Xu ◽  
Cheng-Gang Zhu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Observational Studies ◽  
Meta Analysis ◽  
Artery Disease

Relationship Between Platelet to Lymphocyte Ratio and Stable Coronary Artery Disease: Meta-Analysis of Observational Studies

Angiology ◽  
2020 ◽  
Vol 71 (10) ◽  
pp. 909-915
Author(s):  
Zhiqiang Qiu ◽  
Yu Jiang ◽  
Xinghua Jiang ◽  
Renqiang Yang ◽  
Yanqing Wu ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Collateral Circulation ◽  
Meta Analysis ◽  
Stable Coronary Artery Disease ◽  
Current Evidence ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Artery Disease ◽  
Stable Cad

Recent studies have reported a relationship between the platelet to lymphocyte ratio (PLR) and acute coronary syndromes. The aim of the present study was to investigate the association between PLR and stable coronary artery disease (CAD). A systematic search was conducted based on electronic databases (Cochrane, PubMed, Elsevier, Medline, and Embase). A total of 14 studies (n = 4,871) were included in the meta-analysis. Compared with the non-CAD group, PLR was significantly higher in CAD group ( P = .002). After further classification according to the Gensini score, the cases with atherosclerosis demonstrated a higher PLR than those without atherosclerosis ( P < .001). Platelet to lymphocyte ratio was higher in the severe atherosclerosis group compared with the mild atherosclerosis group ( P < .001). Compared with the poor coronary collateral circulation (CCC) group, PLR was significantly lower in the good CCC group ( P < .001). The PLR was significantly higher in patients with coronary slow flow (CSF) than those with normal coronary flow ( P = .01). On the basis of current evidence, an elevated PLR was associated with stable CAD, and it might be useful for predicting CAD severe stenosis, collateral circulation, and CSF. Future studies are needed to clarify the relationship between PLR and stable CAD.

Increased Peripheral Blood Visfatin Concentrations May Be a Risk Marker of Coronary Artery Disease: A Meta-Analysis of Observational Studies

Angiology ◽  
2018 ◽  
Vol 69 (9) ◽  
pp. 825-834 ◽  
Author(s):  
Fuling Yu ◽  
Jianwei Li ◽  
Qilei Huang ◽  
Hongbin Cai
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Peripheral Blood ◽  
Observational Studies ◽  
Meta Analysis ◽  
Density Lipoprotein ◽  
Risk Marker ◽  
Regression Analyses ◽  
Meta Regression ◽  
Artery Disease

A comprehensive quantitative evaluation of the relationship between peripheral blood visfatin concentrations and coronary artery disease (CAD) is lacking. This study is the first attempt to quantify this relationship via a meta-analysis of published observational studies in terms of weighted mean difference (WMD). Literature retrieval, article selection, and data extraction were conducted. Heterogeneity was inspected using both subgroup and meta-regression analyses. In total, 15 articles involving 1053 CAD cases and 714 controls were included. Overall, peripheral blood visfatin concentrations were significantly higher in CAD cases than in controls (WMD: 4.72 ng/mL; 95% confidence interval [CI]: 2.97-6.47; P < .001), with significant heterogeneity and publication bias. Six studies were theoretically missing based on filled funnel plot, and considering the impact of these missing studies still detected a significant overall mean difference in visfatin (WMD: 2.82 ng/mL; 95% CI: 2.22-3.58; P < .001; number of studies: 21). Subgroup and meta-regression analyses indicated age, body mass index, race, diabetes, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were identified as possible causes of heterogeneity. In conclusion, our findings suggest that increased peripheral blood visfatin concentrations may be a risk marker of CAD.

ATHEROGENIC INDEX OF PLASMA IS A MARKER OF PLAQUE VULNERABILITY IN CORONARY ARTERY DISEASE

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 85A-86A
Author(s):  
YUB RAJ SEDHAI ◽  
SONEY BASNYAT ◽  
PRASAD KONDA ◽  
AJAY KOIRALA ◽  
PARITOSH PRASAI ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Atherogenic Index ◽  
Plaque Vulnerability ◽  
Atherogenic Index Of Plasma ◽  
Artery Disease

Coronary artery disease in primary biliary cirrhosis: A systematic review and meta-analysis of observational studies

2014 ◽  
Vol 45 (11) ◽  
pp. 1055-1061 ◽  
Author(s):  
Patompong Ungprasert ◽  
Karn Wijarnpreecha ◽  
Wasin Ahuja ◽  
Ittikorn Spanuchart ◽  
Charat Thongprayoon
Keyword(s):  
Systematic Review ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Primary Biliary Cirrhosis ◽  
Observational Studies ◽  
Meta Analysis ◽  
Biliary Cirrhosis ◽  
Artery Disease

scholarly journals Correlation between Atherogenic index and the severity of coronary artery disease in diabetic patients undergoing elective coronary angiography using Gensini score

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A S Elyamani ◽  
M A Elnozahi ◽  
A M Abdelmoteleb
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Significant Positive Correlation ◽  
Atherogenic Index ◽  
Diabetic Patients ◽  
Gensini Score ◽  
Atherogenic Index Of Plasma ◽  
Positive Correlation ◽  
Artery Disease

Abstract Background Dyslipidemia is one of the most important factors for CAD. Atherogenic index of plasma (AIP) is a new indicator involved in dyslipidemia. However, its relation with CAD severity in diabetic patients is not well established yet. Aim of the Study To study the relationship between atherogenic index of plasma and severity of coronary artery disease (CAD) in the diabetic patients. Methods Our study was conducted on 150 diabetic patient with stable CAD undergoing elective coronary angiography in Al-Agoza Hospital from april 2016 to august 2018. Atherogenic index was calculated from the logarithmically transformed ratio of concentrations of TGs to HDL-C obtained from the patient’s lipid profile. correlation of the AIP and the severity of CAD according to Gensini scoring system was done. Results AIP had a statistically significant positive relation with IDDM (p = 0.033), NIDDM (p = 0.033), HTN (p = 0.024), dyslipedemia (p = 0.042). And a highly significant positive correlation with FBS (p &lt; 0.001, r = 0.479) and HbA1c (p &lt; 0.001, r = 0.538), proximal LAD lesions (p = 0.002), LCX (p &lt; 0.001), and the number of vessls affected (p = 0.005). AIP Also had a highly significant positive correlation with severity of CAD in terms of Gensini score (p &lt; 0.001, r = 0.692). Conclusion AIP is considered a good predictor of CAD severity and multivessel affection in diabetic patients.

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