scholarly journals Causal Associations of Obesity With the Intervertebral Degeneration, Low Back Pain, and Sciatica: A Two-Sample Mendelian Randomization Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Jingzhu Zhou ◽  
Jiarui Mi ◽  
Yu Peng ◽  
Huirong Han ◽  
Zhengye Liu

The role of obesity in the development of dorsopathies is still unclear. In this study, we assessed the associations between body mass index (BMI) and several dorsopathies including intervertebral disc degeneration (IVDD), low back pain (LBP), and sciatica by using the Mendelian randomization method. We also assessed the effect of several obesity-related traits on the same outcomes. Single-nucleotide polymorphisms associated with the exposures are extracted from summary-level datasets of previously published genome-wide association studies. Summary-level results of IVDD, LBP, and sciatica were from FinnGen. In our univariable Mendelian randomization analysis, BMI is significantly associated with increased risks of all dorsopathies including sciatica (OR = 1.33, 95% CI, 1.21–1.47, p = 5.19 × 10-9), LBP (OR = 1.28, 95% CI, 1.18–1.39, p = 6.60 × 10-9), and IVDD (OR = 1.23, 95% CI, 1.14–1.32, p = 2.48 × 10-8). Waist circumference, hip circumference, whole-body fat mass, fat-free mass, and fat percentage, but not waist–hip ratio, were causally associated with increased risks of IVDD and sciatica. Higher hip circumference, whole-body fat mass, fat-free mass, and fat percentage increased the risk of LBP. However, only whole-body fat-free mass remained to have a significant association with the risk of IVDD after adjusting for BMI with an odds ratio of 1.57 (95% CI, 1.32–1.86, p = 2.47 × 10-7). Proportions of BMI’s effect on IVDD, sciatica, and LBP mediated by leisure sedentary behavior were 41.4% (95% CI, 21.8%, 64.8%), 33.8% (95% CI, 17.5%, 53.4%), and 49.7% (95% CI, 29.4%, 73.5%), respectively. This study provides evidence that high BMI has causal associations with risks of various dorsopathies. Weight control is a good measure to prevent the development of dorsopathies, especially in the obese population.

2010 ◽  
Vol 33 (3) ◽  
pp. 268-270 ◽  
Author(s):  
Audy P. Hodselmans ◽  
Pieter U. Dijkstra ◽  
Jan H.B. Geertzen ◽  
Cees P. van der Schans

Medicine ◽  
2018 ◽  
Vol 97 (38) ◽  
pp. e12534
Author(s):  
Yi-Li Zheng ◽  
Zhi-Jie Zhang ◽  
Meng-Si Peng ◽  
Hao-Yu Hu ◽  
Ju Zhang ◽  
...  

Trials ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 104 ◽  
Author(s):  
Xue-Qiang Wang ◽  
Yan-Lin Pi ◽  
Pei-Jie Chen ◽  
Bin-Lin Chen ◽  
Lei-Chao Liang ◽  
...  

2000 ◽  
Vol 160 (21) ◽  
pp. 3265 ◽  
Author(s):  
Yoshitaka Toda ◽  
Neil Segal ◽  
Tamami Toda ◽  
Tadanobu Morimoto ◽  
Ryokei Ogawa

1998 ◽  
Vol 215 (4) ◽  
pp. 687-697 ◽  
Author(s):  
M.H. Pope ◽  
D.G. Wilder ◽  
M. Magnusson

2019 ◽  
Vol 92 (1103) ◽  
pp. 20190300
Author(s):  
Andrew D. Weedall ◽  
Adrian J. Wilson ◽  
Sarah C. Wayte

Objective: To validate MRI fat measurement protocols using purpose built test objects and by comparison with air-displacement plethysmography (ADP) whole-body fat measurements in non-obese subjects. Methods: Test objects of known fat concentration were used to quantify the accuracy of the MRI measurements. 10 participants with a body mass index in the range 18–30 underwent whole-body MRI using two different Dixon-based sequences (LAVA Flex and IDEAL IQ) to obtain an estimate of their whole-body fat mass. The MRI determined fat mass was compared to the fat mass determined by ADP. Results: MRI test object measurements showed a high correlation to expected fat percentage (r > 0.98). The participant MRI and ADP results were highly correlated (r = 0.99) but on average (mean ± standard deviation) MRI determined a higher fat mass than ADP (3.8 ± 3.1 kg for LAVA Flex and 1.9 ± 3.2 kg for IDEAL IQ). There was no trend in the difference between MRI and ADP with total fat mass. Conclusion: The good agreement between MRI and ADP shows that Dixon-based MRI can be used effectively as a tool in physiological research for non-obese adults. Advances in knowledge: This work found that for ten non-obese subjects body mass index had no effect on the MRI determination of whole-body fat mass.


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