scholarly journals Integrated Transcriptome and Histone Modification Analysis Reveals NDV Infection Under Heat Stress Affects Bursa Development and Proliferation in Susceptible Chicken Line

2020 ◽  
Vol 11 ◽  
Author(s):  
Ganrea Chanthavixay ◽  
Colin Kern ◽  
Ying Wang ◽  
Perot Saelao ◽  
Susan J. Lamont ◽  
...  
2011 ◽  
Vol 5 (Suppl 4) ◽  
pp. S7 ◽  
Author(s):  
Juan Luo ◽  
Ying Yu ◽  
Huanmin Zhang ◽  
Fei Tian ◽  
Shuang Chang ◽  
...  

2020 ◽  
Author(s):  
Hao-Teng Zheng ◽  
Zi-Xuan Zhuang ◽  
Chao-Jung Chen ◽  
Hsin-Yi Liao ◽  
Hung-Lin Chen ◽  
...  

Abstract The adrenal gland responds to heat stress by epinephrine and glucocorticoid release to alleviate the adverse effects. This study investigated the effect of acute heat stress on the protein profile and histone modification in the adrenal gland of layer-type country chickens. A total of 192 30-week-old roosters were subject to acute heat stress. A resistant group and a susceptible group were identified according to body temperature change after heat stress. Adrenal glands were collected for global protein expression and histone modification analysis. The results indicated that fatty acid amide hydrolase and parathymosin were downregulated, whereas somatostatin, steroidogenic acute regulatory protein, hydroxy-δ-5-steroid dehydrogenase, 3 beta- and steroid δ-isomerase 1, and prostaglandin E synthase 3 were upregulated in the resistant group. Histone modification analysis identified 115 histone markers. The tri-methylation state of histone H3 lysine 27 (H3K27me3) was significantly more abundant in the susceptible group and showed positive crosstalk with K36me and K37me in the H3 tails. Roosters in the heat-resistant group exhibited lower hypothalamus–pituitary–adrenal axis activity but higher reactivity to maintain body temperature homeostasis. Alteration of adrenal H3K27me3 level was associated with the endocrine function of adrenal H3K27me3 and may have contributed to the thermotolerance of chickens.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hao-Teng Zheng ◽  
Zi-Xuan Zhuang ◽  
Chao-Jung Chen ◽  
Hsin-Yi Liao ◽  
Hung-Lin Chen ◽  
...  

AbstractThe adrenal gland responds to heat stress by epinephrine and glucocorticoid release to alleviate the adverse effects. This study investigated the effect of acute heat stress on the protein profile and histone modification in the adrenal gland of layer-type country chickens. A total of 192 roosters were subject to acute heat stress and thereafter classified into a resistant or susceptible group according to body temperature change. The iTRAQ analysis identified 80 differentially expressed proteins, in which the resistant group had a higher level of somatostatin and hydroxy-δ-5-steroid dehydrogenase but a lower parathymosin expression in accordance with the change of serum glucocorticoid levels. Histone modification analysis identified 115 histone markers. The susceptible group had a higher level of tri-methylation of histone H3 lysine 27 (H3K27me3) and showed a positive crosstalk with K36me and K37me in the H3 tails. The differential changes of body temperature projected in physiological regulation at the hypothalamus–pituitary–adrenal axis suggest the genetic heterogeneity in basic metabolic rate and efficiency for heat dissipation to acclimate to thermal stress and maintain body temperature homeostasis. The alteration of adrenal H3K27me3 level was associated with the endocrine function of adrenal gland and may contribute to the thermotolerance of chickens.


PROTOPLASMA ◽  
2019 ◽  
Vol 256 (5) ◽  
pp. 1245-1256 ◽  
Author(s):  
Haoli Hou ◽  
Lin Zhao ◽  
Xueke Zheng ◽  
Mayank Gautam ◽  
Mengxia Yue ◽  
...  

2019 ◽  
Vol 28 (3) ◽  
pp. 669-678
Author(s):  
Anand Laxmi Nidamanuri ◽  
Leslie Leo Prince Lawerence ◽  
Rama Subbaiah Kothamidde ◽  
Rama Krishna Mahapatra

2018 ◽  
Vol 34 (1) ◽  
pp. 51-64
Author(s):  
A. Hemantaranjan ◽  
◽  
C.P. Malik ◽  
A. Nishant Bhanu ◽  
◽  
...  

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