scholarly journals Chemerin Suppresses Breast Cancer Growth by Recruiting Immune Effector Cells Into the Tumor Microenvironment

2019 ◽  
Vol 10 ◽  
Author(s):  
Russell K. Pachynski ◽  
Ping Wang ◽  
Nicole Salazar ◽  
Yayue Zheng ◽  
Leona Nease ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Growth ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Breast Cancer Growth

scholarly journals The Tumor Microenvironment—A Metabolic Obstacle to NK Cells’ Activity

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3542
Author(s):  
Joanna Domagala ◽  
Mieszko Lachota ◽  
Marta Klopotowska ◽  
Agnieszka Graczyk-Jarzynka ◽  
Antoni Domagala ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Nk Cells ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Nk Cell ◽  
Metabolic Changes ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Almost All

NK cells have unique capabilities of recognition and destruction of tumor cells, without the requirement for prior immunization of the host. Maintaining tolerance to healthy cells makes them an attractive therapeutic tool for almost all types of cancer. Unfortunately, metabolic changes associated with malignant transformation and tumor progression lead to immunosuppression within the tumor microenvironment, which in turn limits the efficacy of various immunotherapies. In this review, we provide a brief description of the metabolic changes characteristic for the tumor microenvironment. Both tumor and tumor-associated cells produce and secrete factors that directly or indirectly prevent NK cell cytotoxicity. Here, we depict the molecular mechanisms responsible for the inhibition of immune effector cells by metabolic factors. Finally, we summarize the strategies to enhance NK cell function for the treatment of tumors.

3D hydrogel-based microwell arrays as a tumor microenvironment model to study breast cancer growth

2017 ◽  
Vol 12 (2) ◽  
pp. 025009 ◽  
Author(s):  
John Casey ◽  
Xiaoshan Yue ◽  
Trung Dung Nguyen ◽  
Aylin Acun ◽  
Victoria R Zellmer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Growth ◽  
Breast Cancer Growth

scholarly journals Metabolites in the Tumor Microenvironment Reprogram Functions of Immune Effector Cells Through Epigenetic Modifications

2021 ◽  
Vol 12 ◽  
Author(s):  
Yijia Li ◽  
Yangzhe Wu ◽  
Yi Hu
Keyword(s):  
Tumor Microenvironment ◽  
Cancer Cells ◽  
Immune Cells ◽  
Expression Patterns ◽  
Immune Effector ◽  
Effector Cells ◽  
Cell Functions ◽  
Metabolic Plasticity ◽  
Signal Transduction Networks ◽  
Immune Effector Cells

Cellular metabolism of both cancer and immune cells in the acidic, hypoxic, and nutrient-depleted tumor microenvironment (TME) has attracted increasing attention in recent years. Accumulating evidence has shown that cancer cells in TME could outcompete immune cells for nutrients and at the same time, producing inhibitory products that suppress immune effector cell functions. Recent progress revealed that metabolites in the TME could dysregulate gene expression patterns in the differentiation, proliferation, and activation of immune effector cells by interfering with the epigenetic programs and signal transduction networks. Nevertheless, encouraging studies indicated that metabolic plasticity and heterogeneity between cancer and immune effector cells could provide us the opportunity to discover and target the metabolic vulnerabilities of cancer cells while potentiating the anti-tumor functions of immune effector cells. In this review, we will discuss the metabolic impacts on the immune effector cells in TME and explore the therapeutic opportunities for metabolically enhanced immunotherapy.

The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment

Oncogene ◽  
2020 ◽  
Vol 39 (16) ◽  
pp. 3292-3304 ◽  
Author(s):  
Timothy P. Brown ◽  
Pushpak Bhattacharjee ◽  
Sabarish Ramachandran ◽  
Sathish Sivaprakasam ◽  
Bojana Ristic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Antigen Presenting Cells ◽  
Cancer Growth ◽  
Breast Cancer Growth ◽  
Antigen Presenting

scholarly journals From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Oana Draghiciu ◽  
Hans W. Nijman ◽  
Toos Daemen
Keyword(s):  
Tumor Microenvironment ◽  
Current Knowledge ◽  
Cancer Development ◽  
Detailed Knowledge ◽  
Immune Effector ◽  
Effector Cells ◽  
Immune Effector Cells ◽  
Tumor Immunosuppression ◽  
Tumor Eradication ◽  
Induction Of Tolerance

Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors.

Abstract 3363: RAGE/S100A7/Stat3-axis enhances breast cancer growth and metastasis via modulating tumor microenvironment

2015 ◽  
Author(s):  
Mohd W. Nasser ◽  
Nissar A. Wani ◽  
Janani Ravi ◽  
Grace A. Amponsah ◽  
Dinesh K. Ahirwar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Growth ◽  
Breast Cancer Growth

Abstract 916: Slit2 inhibits breast cancer growth and metastasis by modulating tumor microenvironment

2016 ◽  
Author(s):  
Dinesh K. Ahirwar ◽  
Mohd W. Nasser ◽  
Mohamad Elbaz ◽  
Kontestine Shilo ◽  
Ramesh Ganju
Keyword(s):  
Breast Cancer ◽  
Tumor Microenvironment ◽  
Cancer Growth ◽  
Breast Cancer Growth
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