scholarly journals Expression of MICA in Zero Hour Biopsies Predicts Graft Survival After Liver Transplantation

2021 ◽  
Vol 12 ◽  
Author(s):  
Thomas Resch ◽  
Hubert Hackl ◽  
Hannah Esser ◽  
Julia Günther ◽  
Hubert Schwelberger ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Function ◽  
Graft Survival ◽  
Predictive Value ◽  
Risk Index ◽  
Graft Function ◽  
Inverse Correlation ◽  
Rank Test ◽  
Short And Long Term

In search for novel biomarkers to assess graft quality, we investigated whether defined candidate genes are predictive for outcome after liver transplantation (LT).Zero-hour liver biopsies were obtained from 88 livers. Gene expression of selected candidate markers was analyzed and correlated with clinical parameters as well as short and long-term outcomes post LT. Whereas both, the calculated Eurotransplant Donor-Risk-Index and the donor body mass index, had either a poor or no predictive value concerning serum levels indicative for liver function (ALT, AST, GGT, bilirubin) after 6 months, chronological donor age was weakly predictive for serum bilirubin (AUC=0.67). In contrast, the major histcompatibility complex class I related chain A (MICA) mRNA expression demonstrated a high predictive value for serum liver function parameters revealing an inverse correlation (e.g. for ALT: 3 months p=0.0332; 6 months p=0.007, 12 months 0.0256, 24 months p=0.0098, 36 months, p=0.0153) and proved significant also in a multivariate regression model. Importantly, high expression of MICA mRNA revealed to be associated with prolonged graft survival (p=0.024; log rank test) after 10 years of observation, whereas low expression was associated with the occurrence of death in patients with transplant related mortality (p=0.031). Given the observed correlation with short and long-term graft function, we suggest MICA as a biomarker for pre-transplant graft evaluation.

scholarly journals Randomized study with cyclosporine in kidney transplantation: 10-year follow-up.

1996 ◽  
Vol 7 (5) ◽  
pp. 792-797
Author(s):  
C Ponticelli ◽  
G Civati ◽  
A Tarantino ◽  
F Quarto di Palo ◽  
G Corbetta ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Graft Survival ◽  
Controlled Trial ◽  
Randomized Study ◽  
Graft Function ◽  
Rank Test ◽  
Cadaveric Renal Transplantation ◽  
Azathioprine Group

This study presents the 10-yr follow-up results of a multicenter controlled trial on 108 recipients of cadaveric renal transplantation, randomized to receive cyclosporine (N = 55) or azathioprine (N = 53), both in combination with steroids. The 10-yr patient survival rate was 89% in the cyclosporine group and 83% in the azathioprine group (P = not significant [NS]); the 10-yr graft survival was 56% and 35%, respectively (log-rank test, P = 0.009). The half-life of grafts functioning after 1 yr was 15.4 +/- 3.9 versus 10.6 +/- 3.6, P = NS). The rate of early rejection in the cyclosporine group was significantly lower than that in the azathioprine group (0.30 versus 1.4, P < 0.01). Although the mean creatinine clearance rate was always higher in the azathioprine group, the decline in graft function from the first to the tenth yr was not significantly different between the two groups (-13.0 +/- 16.4 versus -12.3 +/- 19 mL/min, P = NS). In cadaveric renal transplantation, cyclosporine allows better graft survival than azathioprine, not only in the short term but also in the long term, with similar attrition of graft function for up to 10 yr.

VALIDATION OF THE DONOR RISK INDEX IN PREDICTING LONG-TERM GRAFT SURVIVAL AFTER LIVER TRANSPLANTATION: A SINGLE CENTER EXPERIENCE

2010 ◽  
Vol 90 ◽  
pp. 771 ◽  
Author(s):  
M. S. Abouljoud ◽  
M. M. Elatrache ◽  
A. Yoshida ◽  
D. Y. Kim ◽  
M. M. Kazimi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Risk Index ◽  
Single Center ◽  
Single Center Experience

scholarly journals Reassessment of Relevance and Predictive Value of Parameters Indicating Early Graft Dysfunction in Liver Transplantation: AST Is a Weak, but Bilirubin and INR Strong Predictors of Mortality

2021 ◽  
Vol 8 ◽  
Author(s):  
Margot Fodor ◽  
Adriana Woerdehoff ◽  
Wolfgang Peter ◽  
Hannah Esser ◽  
Rupert Oberhuber ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Survival ◽  
Predictive Value ◽  
Liver Graft ◽  
Rank Test ◽  
Graft Dysfunction ◽  
Log Rank Test ◽  
Early Graft ◽  
Early Graft Dysfunction ◽  
Patient And Graft Survival

Introduction: Early graft dysfunction (EAD) complicates liver transplantation (LT). The aim of this analysis was to discriminate between the weight of each variable as for its predictive value toward patient and graft survival.Methods: We reviewed all LT performed at the Medical University of Innsbruck between 2007 and 2018. EAD was recorded when one of the following criteria was present: (i) aspartate aminotransferase (AST) levels &gt;2,000 IU/L within the first 7 days, (ii) bilirubin levels ≥10mg/dL or (iii) international normalized ratio (INR) ≥1.6 on postoperative day 7.Results: Of 616 LT, 30.7% developed EAD. Patient survival did not differ significantly (P = 0.092; log rank-test = 2.87), graft survival was significantly higher in non-EAD patients (P = 0.008; log rank-test = 7.13). Bilirubin and INR on postoperative day 7 were identified as strong mortality predictors (Bilirubin HR = 1.71 [1.34, 2.16]; INR HR = 2.69 [0.51, 14.31]), in contrast to AST (HR = 0.91 [0.75, 1.10]). Similar results were achieved for graft loss estimation. A comparison with the Model for Early Allograft Function (MEAF) and the Liver Graft Assessment Following Transplantation (L-GrAFT) score identified a superior discrimination potential but lower specificity.Conclusion: Contrarily to AST, bilirubin and INR have strong predictive capacity for patient and graft survival. This fits well with the understanding, that bile duct injury and deprivation of synthetic function rather than hepatocyte injury are key factors in LT.

Short- and Long-Term Outcomes After Living Donor Liver Transplantation

2005 ◽  
Vol 37 (9) ◽  
pp. 3884-3886 ◽  
Author(s):  
A. Moreno Elola-Olaso ◽  
E. Moreno Gonzalez ◽  
J.C. Meneu Diaz ◽  
I. Garcı́a Garcı́a ◽  
C. Loinaz Segurola ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Long Term Outcomes ◽  
Donor Liver ◽  
Donor Liver Transplantation ◽  
Short And Long Term

Application of the BAR score as a predictor of short- and long-term survival in liver transplantation patients

2014 ◽  
Vol 9 (1) ◽  
pp. 113-119 ◽  
Author(s):  
Ivan Dias de Campos Junior ◽  
Raquel Silveira Bello Stucchi ◽  
Elisabete Yoko Udo ◽  
Ilka de Fátima Santana Ferreira Boin
Keyword(s):  
Liver Transplantation ◽  
Term Survival ◽  
Long Term Survival ◽  
Short And Long Term

Long-term Effects of Delayed Graft Function on Pancreas Graft Survival After Pancreas Transplantation

2014 ◽  
Vol 98 (12) ◽  
pp. 1316-1322 ◽  
Author(s):  
Sung Shin ◽  
Duck Jong Han ◽  
Young Hoon Kim ◽  
Seungbong Han ◽  
Byung Hyun Choi ◽  
...  
Keyword(s):  
Graft Survival ◽  
Pancreas Transplantation ◽  
Graft Function ◽  
Delayed Graft Function ◽  
Long Term Effects ◽  
Pancreas Graft

Combined Predictive Value of ECD Criteria for Long-Term Graft Survival of Kidneys From Donors After Cardiac Death.

2014 ◽  
Vol 98 ◽  
pp. 71
Author(s):  
M. Kusaka ◽  
Y. Kubota ◽  
H. Takahashi ◽  
N. Fukami ◽  
H. Sasaki ◽  
...  
Keyword(s):  
Graft Survival ◽  
Predictive Value ◽  
Cardiac Death

Abstract P101: Short and Long-Term Outcomes in Aspirin Treated PCI Patients Using NSAIDs

2011 ◽  
Vol 4 (suppl_1) ◽  
Author(s):  
Rizwan Alimohammad ◽  
Sayed Tariq ◽  
Ali Elkharbotly ◽  
Ed Timm ◽  
Mikhail Torosoff
Keyword(s):  
Myocardial Infarction ◽  
Rank Test ◽  
Long Term Outcomes ◽  
Chi Square ◽  
Low Dose Aspirin ◽  
History Of ◽  
Short And Long Term ◽  
Mortality Table ◽  
Prolonged Hospital

Background: NSAIDs may exert direct deleterious effects on CV system, while non-selective (NS) -NSAIDs may also diminish cardio-protective effect of low-dose aspirin. On another hand, NSAIDs may decrease CRP levels and ameliorate systemic inflammation. We have investigated short and long-term outcomes associated with NSAIDs use in post-PCI patients. Methods and Material: NSAID utilization, hospital and long-term outcomes of 2933 percutaneous coronary revascularizations (PCI) were collected and analyzed. Patients not on aspirin, or treated with rofecoxib and valdecoxib were excluded. ANOVA, Chi-square, Kaplan-Meyer analysis with log-rank test, and logistic regression were utilized. The study was approved by the Institutional IRB. Results: Patients treated with NS-NSAIDs, but not celecoxib, experienced longer length of stay, higher incidence of peri-procedural myocardial infarction, and mildly increased post-PCI mortality (Table). These effects were unchanged after adjustment for age (p=0.001), ejection fraction (p<0.001), and history of previous MI (p<0.001). There was a trend towards lower long-term (50+/-15 months) mortality in NS-NSAIDs (9%) and celecoxib (6.7%) treated patients, when compared to the rest of the cohort (11.3%, Table). Conclusion: Non-selective NSAIDs, but not Celecoxib, are associated with prolonged hospital stay and increased peri-procedural myocardial infarction in PCI patients. Long-term mortality does not appear to be affected by the NSAIDs use at the time of PCI. Randomized studies of this important clinical question are needed.

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