Case Report: Anti-MOG Antibody Seroconversion Accompanied by Dimethyl Fumarate Treatment
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Here we report three cases of anti-myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) mimicking multiple sclerosis in which seropositivity for anti-MOG antibodies occurred during disease-modifying drug dimethyl fumarate (DMF) treatment. These patients developed relapses with anti-MOG antibody seroconversion after switching from fingolimod or steroid pulse therapy to DMF, which was associated with peripheral lymphocyte recovery. MOGAD is considered a humoral immune disease, and DMF reportedly enhances Th2-skewed humoral immune activity. Therefore, we suggest that DMF, but not fingolimod, may exacerbate humoral immune imbalance and enhance autoantibody production, leading to aggravation of MOGAD.
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2008 ◽
Vol 11
(2)
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pp. 181-184
2005 ◽
Vol 64
(8)
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pp. 1236-1237
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2017 ◽
Vol 21
(6)
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pp. 1068-1074
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