scholarly journals Active Inflammatory and Chronic Structural Damages of Sacroiliac Joint in Patients With Radiographic Axial Spondyloarthritis and Non-Radiographic Axial Spondyloarthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Liudan Tu ◽  
Churong Lin ◽  
Ya Xie ◽  
Xiaohong Wang ◽  
Qiujing Wei ◽  
...  

ObjectiveEvaluate the MRI evidence of active inflammatory and chronic structural damages in radiographic axial spondyloarthritis (r-axSpA) and non-radiographic axial spondyloarthritis (nr-axSpA).MethodsA retrospective review of 253 patients who underwent sacroiliac joint (SIJ) MRI between June 2014 and December 2019 was performed. MRI images including short tau inversion recovery scan and T1-weighted spin echo scans were assessed using the Spondyloarthritis Research Consortium of Canada (SPARCC) score and SPARCC MRI SIJ structural score by two independent readers.ResultsHigher mean score of inflammatory (SPARCC) was seen in r-axSpA patients when compared with nr-axSpA patients (8.08 vs 4.37, P<0.05). Frequencies of MRI structural lesions in r-axSpA patients and nr-axSpA patients were as follows: erosion (65.84 vs 88.23%, P=0.002), backfill (33.17 vs 13.73%, P<0.001), fat metaplasia (79.21 vs 60.78%, P=0.01), and ankylosis (37.13 vs 1.96%, P<0.001). Patients with r-axSpA had a higher mean score for fat metaplasia (8.93 vs 4.06, P=0.0003) and ankylosis (4.49 vs 0.04, P<0.001).ConclusionMore active inflammatory and chronic structural damages except for erosion were seen in r-axSpA patients than nr-axSpA patients, while higher percentage of nr-axSpA patients presented with erosion in MRI.

2017 ◽  
Vol 04 (02) ◽  
pp. 174-180
Author(s):  
Lakshmi Ranganathan ◽  
Venkatraman Karthikeayan ◽  
Arun MM ◽  
Guhan R. ◽  
Venkateswaran KJ ◽  
...  

Radiology ◽  
1992 ◽  
Vol 182 (1) ◽  
pp. 205-211 ◽  
Author(s):  
M E Schweitzer ◽  
S K Brahme ◽  
J Hodler ◽  
G J Hanker ◽  
T P Lynch ◽  
...  

2021 ◽  
pp. jrheum.201075
Author(s):  
Marie Wetterslev ◽  
Mikkel Østergaard ◽  
Inge Juul Sørensen ◽  
Ulrich Weber ◽  
Anne Gitte Loft ◽  
...  

Objective In axial spondyloarthritis (axSpA), sacroiliac joint (SIJ) erosion is often followed by fat metaplasia in an erosion cavity (backfill), and subsequently ankylosis. We aimed to combine Spondyloarthritis Research Consortium of Canada (SPARCC) SIJ Structural score for Erosion, Backfill and Ankylosis into 3 versions of a novel preliminary Composite axSpA MRI SIJ Structural Damage Score (CSDS) and test these. Methods Thirty-three axSpA patients followed for 5 years after initiation of tumor necrosis factor inhibitor had MRI of SIJs at baseline, and yearly thereafter. Three versions of CSDSs were calculated based on different weightings of erosion, backfill and ankylosis: Equal weighting: CSDSequal=(erosion x0.5)+backfill+ankylosis; Advanced stages weighting more: CSDSstepwise=(erosion x1)+(backfill x4)+(ankylosis x6); Advanced stages overruling earlier stages (“hierarchical”) with “<” meaning “overruled by”: CSDShierarchical=(erosion x1)<(backfill x4)<(ankylosis x6). Results At baseline all CSDSs correlated positively with SPARCC Fat and Ankylosis, modified New Yorkradiography grading and negatively with BASDAI and SPARCC SIJ Inflammation. CSDSstepwise and CSDShierarchical (not CSDSequal) correlated positively with symptom duration and BASMI, and closer with SPARCC ankylosis and Modified New York-radiography grading than CSDSequal. The adjusted annual progression rate for CSDSstepwise and CSDShierarchical (not CSDSequal) was higher the first year compared with fourth year (p=0.04 and p=0.01). Standardized response mean (baselineweek 46) was moderate for CSDShierarchical (0.64) and CSDSstepwise (0.59) and small for CSDSequal (0.25). Conclusion Particularly CSDSstepwise and CSDShierarchical showed construct validity and responsiveness, encouraging further validation in larger clinical trials. The potential clinical implication is assessment of sacroiliac joint damage progression by one composite score.


1996 ◽  
Vol 75 (02) ◽  
pp. 83-87 ◽  
Author(s):  
A. Dreher ◽  
G. U. Müller-Lisse ◽  
Ulrike L. Kretschmar ◽  
L. J. E. Jäger ◽  
G. Grevers

1994 ◽  
Vol 12 (7) ◽  
pp. 983-989 ◽  
Author(s):  
J.W. Thorpe ◽  
D.G. MacManus ◽  
B.E. Kendall ◽  
P.S. Tofts ◽  
G.J. Barker ◽  
...  

2021 ◽  
pp. 197140092110177
Author(s):  
Chian A Chang ◽  
Abigail L Chong ◽  
Ronil V Chandra ◽  
Ernest Butler ◽  
Deepa Rajendran ◽  
...  

Background and purpose The magnetic resonance imaging in multiple sclerosis consensus guidelines currently mandate three sagittal non-contrast enhanced sequences of T2-weighted fast spin echo, proton density-weighted fast spin echo and short tau inversion recovery; however, these particular three sequences have not previously been compared at 3T. This study compared T2-weighted fast spin echo, proton density-weighted fast spin echo, short tau inversion recovery as well as the double inversion recovery sequence for the sagittal detection of multiple sclerosis lesions in the cervical spinal cord at 3T. Methods Nineteen multiple sclerosis patients underwent magnetic resonance imaging with 3T sagittal T2-weighted fast spin echo, proton density-weighted fast spin echo, short tau inversion recovery and double inversion recovery between November 2012 and April 2013. Two neuroradiologists independently reviewed the images, and the number of lesions detected on each sequence was recorded. Lesion conspicuity was quantitatively assessed with the lesion-to-cord-contrast ratio and lesion contrast-to-noise ratio. The Wilcoxon signed rank test was performed for statistical analysis. Results Proton density-weighted fast spin echo and short tau inversion recovery detected 32% more lesions compared to T2-weighted fast spin echo, and 37% more lesions compared to double inversion recovery. The lesion-to-cord-contrast ratio was highest in short tau inversion recovery, while the lesion contrast-to-noise ratio was highest for proton density-weighted fast spin echo. Conclusions This study provides the necessary evidentiary support at 3T for the magnetic resonance imaging in multiple sclerosis spinal magnetic resonance imaging protocol consensus guidelines. At 3T sagittal proton density-weighted fast spin echo and short tau inversion recovery sequences allowed improved detection of cervical spinal cord multiple sclerosis lesions, compared to T2-weighted fast spin echo and three-dimensional double inversion recovery magnetic resonance imaging. Utilising T2-weighted fast spin echo alone at 3T is insufficient for lesion detection.


2019 ◽  
Vol 46 (4) ◽  
pp. 376-383 ◽  
Author(s):  
Juliane Greese ◽  
Torsten Diekhoff ◽  
Joachim Sieper ◽  
Carsten Schwenke ◽  
Marcus R. Makowski ◽  
...  

Objective.To compare proton density–weighted short-tau inversion recovery (PD-STIR) and T2-weighted fat-suppressed turbo spin echo (T2-FS) sequences for detecting osteitis lesions of the sacroiliac joints (SIJ) in patients with chronic low back pain (CLBP).Methods.This prospective study included 110 patients with CLBP and suspected spondyloarthritis and 18 healthy controls. All 128 participants (age range: 19–57 yrs) underwent 3.0 Tesla magnetic resonance imaging (MRI) of the SIJ including PD-STIR and T2-FS. Two readers independently scored PD-STIR and T2-FS images for osteitis in separate sessions. Sum scores and signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were calculated. Images were further analyzed as to whether they fulfilled the Assessment of SpondyloArthritis international Society (ASAS) criterion of a positive MRI (MRI+). Interreader agreement was calculated using intraclass correlation coefficients.Results.Average osteitis sum scores were higher for T2-FS images (mean sum score of 4.10 in T2-FS vs 2.55 in PD-STIR, p = 0.017). Mean SNR was 16.54 for PD-STIR and 37.30 for T2-FS (p = 0.0289). Mean CNR was 4.14 for PD-STIR and 20.20 for T2-FS (p = 0.0212). For both readers, the ASAS MRI+ definition was more often fulfilled by T2-FS than by PD-STIR images, resulting in more patients being classified as having axial spondyloarthritis (axSpA): 68 patients using T2-FS versus 58 patients using PD-STIR. Interreader intraclass correlation coefficients were very good for both PD-STIR (0.91) and T2-FS (0.86).Conclusion.T2-FS sequences improve image quality and hence the detection of osteitis compared to the PD-STIR sequence. More patients were classified as axSpA based on a positive MRI by T2-FS.


2016 ◽  
Vol 44 (04) ◽  
pp. 231-241
Author(s):  
Daniela Mader ◽  
Uta Delling ◽  
Tobias Theuß ◽  
Kristin Müller ◽  
Julia Offhaus ◽  
...  

Zusammenfassung Ziel der Studie war, die diagnostische Aussagekraft der mittels Niederfeld- Magnetresonanztomographie (MRT) erhobenen Befunde bei septischen Erkrankungen im Hufbereich nach durchdringenden Verletzungen (Nageltritt) zu überprüfen. Material und Methoden: Bei 10 Pferden mit Verletzungen im Hufbereich wurden die MRT-Befunde mittels klinischer, chirurgischer, röntgenologischer, sonographischer und computertomographischer Befunde und/oder postmortaler histologischer Untersuchung validiert. Ergebnisse: Am genauesten ließ sich eine Beteiligung des Strahlbeins nachweisen, die am besten in der fettunterdrückten Sequenz (Short-Tau-Inversion-Recovery-Sequenz, STIR) ermittelt wurde. Defekte der tiefen Beugesehne waren ausgezeichnet nachweisbar, aber unspezifischer als Veränderungen des Strahlbeins. Sie ließen sich am besten in transversalen T2-gewichteten Fast-Spin- Echo-Sequenzen (T2w FSE) nachvollziehen. Der Stichkanal war in sämtlichen Fällen in allen Ebenen erkennbar. Auch hier erwies sich die T2w FSE als gut geeignet. Am wenigsten deutlich konnte die septische Bursitis nachvollzogen werden. Eine Erkrankung der Bursa war am besten in der sagittalen Ebene erkennbar. Schlussfolgerung und klinische Relevanz: Die MRT-Diagnostik von Erkrankungen im Hufbereich nach Verletzung durch Fremdkörper (vor allem Nageltritt) stellt eine zuverlässige Untersuchungsmethode zur Absicherung der Diagnose dar. Dabei eignet sich eine transversale T2w FSE am besten zum Nachweis eines Stichkanals und Sehnendefekts. Für die Diagnostik der Bursitis sind der Stichkanalverlauf und sekundäre Reaktionen des Strahlbeins ausschlaggebend. Fettunterdrückte Sequenzen können eine Knochenbeteiligung gut nachweisen, wenn der Stichkanal nicht direkt bis auf den Knochen zu verfolgen ist. Die beschriebenen Fälle verdeutlichen, dass bei durchdringenden Verletzungen im Hufbereich eine MRT-Untersuchung angezeigt sein kann, wenn die Beteiligung von Strukturen vermutet wird, die eine schlechte Prognose bedingen. Nur die MRT erlaubt intravital eine Beurteilung der verschiedenen Strukturen innerhalb der Hornkapsel. Diese Information wie derum ist essenziell bei der Entscheidungsfindung für eine gezielte Therapie bzw. einer Vermeidung unnötiger Behandlungen.


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