scholarly journals Serum Lactate Dehydrogenase Level as a Prognostic Factor for COVID-19: A Retrospective Study Based on a Large Sample Size

2022 ◽  
Vol 8 ◽  
Author(s):  
Yihui Huang ◽  
Liang Guo ◽  
Jiwei Chen ◽  
Meng Wu ◽  
Chao Zhang ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Cox Regression ◽  
Continuous Variable ◽  
Serum Lactate ◽  
Hospital Death ◽  
Serum Lactate Dehydrogenase ◽  
Large Sample Size ◽  
Regression Analyses ◽  
Clinical Prognosis ◽  
Kaplan Meier

Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression and prognosis of patients with COVID-19.Methods: We retrospectively reviewed the information of 1,751 patients with COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate and multivariate Cox regression analyses as well as Logistics regression analyses, and Kaplan-Meier curves were used to determine the association between LDH levels and the prognosis of COVID-19 patients.Results: LDH was an independent risk factor for in-hospital death no matter it was taken as classified variable and continuous variable (all P = 0.001) but not for severe or critical illness status. The Kaplan-Meier curves for LDH level showed that an elevated level of LDH was associated with in-hospital death.Conclusions: In patients with COVID-19, the increased LDH level is associated with a higher risk of negative clinical prognosis and higher mortality. This will provide a reference for clinicians and researchers to understand, diagnose, and treat patients with COVID-19. Further prospective studies with larger sample sizes are needed to verify these findings.

scholarly journals The Association between Serum Lactate Dehydrogenase Level and In-hospital Death due to Pulmonary Embolism

2021 ◽  
Author(s):  
Samad Ghaffari ◽  
Reza Hajizadeh ◽  
Tooba Mohammadi ◽  
Hadis Kavandi ◽  
Kamran Mohammadi ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Lactate Dehydrogenase ◽  
Lactate Dehydrogenase Level ◽  
Cross Sectional Study ◽  
Serum Lactate ◽  
Hospital Death ◽  
Serum Lactate Dehydrogenase ◽  
Cross Sectional ◽  
Serum Lactate Dehydrogenase Level ◽  
The Mean

Abstract Background: Few studies are evaluating the prognostic value of lactate dehydrogenase (LDH) in patients with pulmonary embolism (PE). We analyzed the possible power of serum LDH levels to predict in-hospital mortality.Methods: In this cross-sectional study 217 patients with confirmed PE diagnosis with CT angiography and available serum LDH level at first 24-hours upon admission were included.Results: The mean age of patients was 63.04±16.81 years old, 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that only LDH, WBC were independent predictors of in-hospital mortality, however, this association was not significant.Conclusion: LDH can be a good prognostic marker for predicting in-hospital death in patients with pulmonary embolism.

scholarly journals The Association Between Serum Lactate Dehydrogenase Level and in-hospital Death Due to Pulmonary Embolism

2021 ◽  
Author(s):  
Samad Ghaffari ◽  
Tooba Mohammadi ◽  
Reza Hajizadeh ◽  
Hadiseh Kavandi ◽  
Kamran Mohammadi ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Lactate Dehydrogenase ◽  
Hospital Mortality ◽  
Lactate Dehydrogenase Level ◽  
Cross Sectional Study ◽  
Serum Lactate ◽  
Hospital Death ◽  
Serum Lactate Dehydrogenase ◽  
Cross Sectional ◽  
Serum Lactate Dehydrogenase Level

Abstract Background: There are few studies evaluating the prognostic value of lactate dehydrogenase (LDH) in patients with pulmonary embolism (PE). We analyzed possible power of serum LDH level to predict in-hospital mortality. Methods: In this cross-sectional study 217 patients with confirmed PE diagnosis with CT angiography and available serum LDH level at first 24-hours upon admission were included. Results: The mean age of patients were 63.04±16.81 years old, 23 patients (10.6%) died during hospitalization. Multivariate analysis showed that only LDH, WBC were independent predictors of in-hospital mortality, however this association was not significant. Conclusions: In patients with pulmonary embolism, LDH can be a good prognostic marker for predicting in-hospital death.

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

A Rapid Electrophoretic Method for the Determination of the Isoenzymes of Serum Lactate Dehydrogenase

1966 ◽  
Vol 12 (5) ◽  
pp. 308-313 ◽  
Author(s):  
Albert W Opher ◽  
Charles S Collier ◽  
Joseph M Miller
Keyword(s):  
Enzyme Activity ◽  
Lactate Dehydrogenase ◽  
Quantitative Determination ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Electrophoretic Method ◽  
The Individual ◽  
Electrophoretic Procedure ◽  
Purple Formazan

Abstract A convenient electrophoretic procedure for the separation and quantitation of lactate dehydrogenase (LDH) isoenzymes is described. The system uses polyacetate Sepraphore III strips.* The areas of activity are shown by incubation with an LDH substrate combined with tetra-nitro-blue-tetrazolium. The reduction of the latter to the purple formazan is quantitatively related to the enzyme activity. Quantitative determination of the individual colored areas is performed by densitometry.

Serum Lactate Dehydrogenase Level in Patients with Nasopharyngeal Carcinoma

1997 ◽  
Vol 36 (2) ◽  
pp. 159-164 ◽  
Author(s):  
Chuang-Chi Liaw ◽  
Cheng-Hsu Wang ◽  
Jen-Sheng Huang ◽  
Mee-Chou Kiu ◽  
Jen-Shi Chen ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Nasopharyngeal Carcinoma ◽  
Lactate Dehydrogenase Level ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Serum Lactate Dehydrogenase Level
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