scholarly journals Long-Term Survival Outcomes and Comparison of Different Treatment Modalities for Stage I-III Cervical Esophageal Carcinoma

2021 ◽  
Vol 8 ◽  
Author(s):  
Yanwei Lu ◽  
Chenwang Xu ◽  
Haitao Wang ◽  
Tao Song ◽  
Shixiu Wu ◽  
...  

Purpose: To investigate the survival outcomes, prognostic factors and treatment modalities of stage I-III cervical esophageal carcinoma (CEC) patients using data from the Surveillance, Epidemiology, and End Results (SEER) database from the period 2004–2016.Methods: Patients with a histopathologic diagnosis of CEC were included. The primary endpoint was overall survival (OS). Univariate and multivariate analyses of OS were performed using Cox proportional hazards models, and OS was compared using the Kaplan-Meier method and log-rank test.Results: A total of 347 patients in the SEER database were enrolled. The median OS was 14.0 months, with a 5-year OS rate of 20.9%. The parameters that were found to significantly correlate with OS in the multivariate analysis were age at diagnosis [P < 0.001, hazard ratio (HR) = 1.832], sex [P < 0.001, HR= 1.867], histology [P = 0.001, HR = 0.366], surgery at the primary site [P = 0.021, HR = 0.553], radiotherapy (RT, P = 0.017, HR = 0.637) and chemotherapy (CT, P < 0.001, HR = 0.444). Comparison among the three treatment modalities demonstrated that a triple therapy regimen consisting of surgery, RT and CT was associated with a longer survival time than the other two treatment modalities before and after propensity score matching (PSM). However, triple therapy showed no significant survival benefit over double therapy (P = 0.496 before PSM and P = 0.184 after PSM).Conclusions: The survival of patients with CEC remains poor. Surgery, RT and CT were all strongly correlated with OS. We recommend a triple therapy regimen for select CEC patients based on the findings of the current study, although this recommendation should be further confirmed by prospective studies with large sample sizes.

2015 ◽  
Vol 55 (5) ◽  
pp. 592-600 ◽  
Author(s):  
Holly Kimko ◽  
An Thyssen ◽  
Diane R. Mould ◽  
Erik Mannaert ◽  
William R. Treem

2017 ◽  
Vol 32 (6) ◽  
pp. 2894-2901 ◽  
Author(s):  
Katelin A. Mirkin ◽  
Audrey S. Kulaylat ◽  
Christopher S. Hollenbeak ◽  
Evangelos Messaris

2004 ◽  
Vol 51 (1) ◽  
pp. 49-54 ◽  
Author(s):  
Predrag Pesko ◽  
Vojko Djukic ◽  
Aleksandar Simic ◽  
Predrag Sabljak ◽  
Dejan Stojakov ◽  
...  

In the period between January 1st, 1978 and January 1st, 2003, 82 unselected patients with hypopharyngeal and cervical esophageal squamocellular carcinoma were treated at the Department of Esophagogastric Surgery, First University Surgical Hospital, Clinical Center of Serbia. In 43 (52,4%) patients operated with curative intent, radical surgical en-block resection and functional neck dissection has been performed. In 26 (60,5%) patient reconstruction was performed with stomach, in 11 (25,6%) left colon, and 6 (14%) free jejunal transfer. The overall 2-year and 5-year survival rate were 55.88 % (19 patients) and 26.47 % (9 patients), respectively. No patient undergoing nutritive gastrostomy and radiotherapy was alive after two years. At present surgery looks like the treatment of choice for hypopharyngeal and cervical esophageal carcinoma, providing a definitive palliation of dysphagia and better long-term survival. Free jejunal transfer has become the standard technique for reconstruction of the pharynx and hypopharynx especially with proximal lesions, whereas, gastric tube interposition is the technique of choice for reconstruction of the hypopharynx and cervical esophagus when the resection extends below the thoracic inlet or when there is a presence of synchronous carcinoma of the esophageal.


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