scholarly journals TAFRO Syndrome in a Kidney Transplant Recipient That Was Diagnosed on Autopsy: A Case Report

2021 ◽  
Vol 8 ◽  
Author(s):  
Marie Nagai ◽  
Takahiro Uchida ◽  
Muneharu Yamada ◽  
Shuuhei Komatsu ◽  
Kohei Ota ◽  
...  

A 57-year-old man who received a kidney transplant 4 years previously owing to unknown underlying disease presented with thrombocytopenia and fever. Hepatosplenomegaly and lymphadenopathy were observed, and development of prominent anasarca and worsening of renal function yielded the diagnosis of TAFRO syndrome. He was treated with high-dose steroids and plasmapheresis, and a thrombopoietin receptor agonist was administered for refractory thrombocytopenia. However, his general condition worsened, and he died on day 92. Histopathological analysis of a kidney autopsy specimen showed thrombotic microangiopathy characterized by glomerular endothelial swelling, mesangiolysis, and double contours of the glomerular capillary walls. His bone marrow showed megakaryocytic hyperplasia with mild reticulin fibrosis. Interestingly, these clinical and pathological features were remarkably similar to those the patient demonstrated before the kidney transplant, suggesting the recurrence of TAFRO syndrome. TAFRO syndrome is a rare systemic disorder whose concept has recently been established, but information on its long-term outcome is scarce. To our knowledge, this is the first case of TAFRO syndrome developing in a kidney transplant recipient, which suggests that disease recurrence occurs many years after the kidney transplant.

2016 ◽  
Vol 5 (2) ◽  
pp. 168-172
Author(s):  
Masaaki Yanishi ◽  
Hiroyasu Tsukaguchi ◽  
Takashi Yoshida ◽  
Hisanori Taniguchi ◽  
Kenji Yoshida ◽  
...  

2014 ◽  
Vol 24 (3) ◽  
pp. 323-325 ◽  
Author(s):  
E. Amazan ◽  
N. Desbois ◽  
G. Fidelin ◽  
É. Baubion ◽  
C. Derancourt ◽  
...  

2014 ◽  
Vol 63 (1) ◽  
pp. 140-143 ◽  
Author(s):  
Young Keun Kim ◽  
Jin-Rok Oh ◽  
Hee Kyoung Choi ◽  
Hyo Youl Kim ◽  
Soon Deok Park ◽  
...  

Nocardia nova is a rare aetiological pathogen for cutaneous nocardiosis. To the best of our knowledge, this is the first case of N. nova primary cutaneous infection in a kidney transplant recipient. Identification was performed using 16S rRNA and secA1 gene sequence analyses. The patient was not treated successfully by antibiotics alone. Surgical debridement was required for successful treatment.


2021 ◽  
pp. 195-203
Author(s):  
Katarzyna Muras-Szwedziak ◽  
Maciej Tylski ◽  
Anna Masajtis-Zagajewska ◽  
Michał Nowicki

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon life-threatening condition caused by an uncontrolled immunological response. It can develop secondary to malignancies, infections, systemic diseases, and immunosuppression. Multiple risk factors may present in kidney transplant recipients; however, the cases of HLH in this population have been described sparsely. We report a case of a 39-year-old female kidney transplant recipient who presented to the hospital nearly 3.5 years after the transplantation with general malaise, recent history of weight loss, fevers, and persistent anemia. Laboratory tests showed pancytopenia, hyperferritinemia, hypertriglyceridemia, and increased activity of lactate dehydrogenase. A bone marrow aspiration revealed hemophagocytosis, which led to the diagnosis of HLH. Therapy consisting of high-dose steroids and plasma exchanges was administered, resulting in a significant improvement of blood count parameters and the patient’s general condition. While searching for the triggering disease, a single cavitary lesion in the right lung was revealed in a chest radiograph. Computed tomography scan, bronchoscopy, and additional laboratory testing did not reveal a definitive cause of the lesion. We suspect that the lesion may be a consequence of HLH. The patient was disqualified from thoracic surgery due to multiple comorbidities. Even though HLH is a rare condition, it should be taken into consideration in a kidney transplant patient presenting with unspecific symptoms accompanied by a bicytopenia. It has an unpredictable course that often results in serious complications. Thus close follow-up of the patient and a wide array of imaging and laboratory tests remain crucial.


Children ◽  
2021 ◽  
Vol 8 (11) ◽  
pp. 1013
Author(s):  
Alessia Marcellino ◽  
Cristiana Alessia Guido ◽  
Silvia Bloise ◽  
Saverio Mallardo ◽  
Sara Isoldi ◽  
...  

Background: actual literature suggests that children of methylmalonic acidemia patients are mostly healthy, but data are only partial, especially regarding long-term outcome. Therefore, our aim was to evaluate the possible long-term neurological effects of fetal exposure to high levels of methylmalonic acid in a child of a renal transplant recipient. Methods: we retrospectively evaluated the clinical and neurological records of a girl whose mother is a kidney transplant recipient affected by methylmalonic acidemia. Subsequently, we compared our results with the ones already published. Results: the girl’s weight and stature were within the normal range in the first years of life but, starting from 4 years of age, she became progressively overweight. Regarding the neurodevelopment aspects, for the first time we performed a complete and seriated neuropsychological evaluation, highlighting a mild but significant weakness in the verbal domain, with a worsening trend at three-year revaluation. Conclusions: since children of MMA patients are exposed to methylmalonic acid, the efforts of the physicians caring for these children should be directed on careful evaluation of growth, prevention of obesity and regular neurological examination together with structured neuropsychological tests to achieve a better insight in possible complications of pregnancy in patients suffering from this condition.


2008 ◽  
Vol 15 (4) ◽  
pp. 369-371 ◽  
Author(s):  
Kiyokazu Akioka ◽  
Masahiko Okamoto ◽  
Hidetaka Ushigome ◽  
Shuji Nobori ◽  
Satoshi Kaihara ◽  
...  

2020 ◽  
Vol 20 (7) ◽  
pp. 1944-1946 ◽  
Author(s):  
David Marx ◽  
Bruno Moulin ◽  
Samira Fafi‐Kremer ◽  
Ilies Benotmane ◽  
Gabriela Gautier ◽  
...  

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