scholarly journals Plasma β-Amyloid Levels Associated With Structural Integrity Based on Diffusion Tensor Imaging in Subjective Cognitive Decline: The SILCODE Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoni Wang ◽  
Mingyan Zhao ◽  
Li Lin ◽  
Ying Han
Keyword(s):  
Diffusion Tensor Imaging ◽  
Cognitive Decline ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Poor Performance ◽  
High Plasma ◽  
The Body ◽  
Subjective Cognitive Decline ◽  
Β Amyloid

Background: Accumulating evidence has demonstrated that plasma β-amyloid (Aβ) levels are useful biomarkers to reflect brain amyloidosis and gray matter structure, but little is known about their correlation with subclinical white matter (WM) integrity in individuals at risk of Alzheimer's disease (AD). Here, we investigated the microstructural changes in WM between subjects with low and high plasma Aβ levels among individuals with subjective cognitive decline (SCD).Methods: This study included 142 cognitively normal individuals with SCD who underwent a battery of neuropsychological tests, plasma Aβ measurements, and diffusion tensor imaging (DTI) based on the Sino Longitudinal Study on Cognitive Decline (SILCODE). Using tract-based spatial statistics (TBSS), we compared fractional anisotropy (FA), and mean diffusivity (MD) in WM between subjects with low (N = 71) and high (N = 71) plasma Aβ levels (cut-off: 761.45 pg/ml for Aβ40 and 10.74 pg/ml for Aβ42).Results: We observed significantly decreased FA and increased MD in the high Aβ40 group compared to the low Aβ40 group in various regions, including the body, the genu, and the splenium of the corpus callosum; the superior longitudinal fasciculus; the corona radiata; the thalamic radiation; the external and internal capsules; the inferior fronto-occipital fasciculus; and the sagittal stratum [p < 0.05, familywise error (FWE) corrected]. Average FA values were associated with poor performance on executive and memory assessments. No significant differences were found in either MD or FA between the low and high Aβ42 groups.Conclusion: Our results suggest that a correlation exists between WM integrity and plasma Aβ40 levels in individuals with SCD.

scholarly journals White matter degeneration in subjective cognitive decline: a diffusion tensor imaging study

Oncotarget ◽  
2016 ◽  
Vol 7 (34) ◽  
pp. 54405-54414 ◽  
Author(s):  
Xuan-yu Li ◽  
Zhen-chao Tang ◽  
Yu Sun ◽  
Jie Tian ◽  
Zhen-yu Liu ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cognitive Decline ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Subjective Cognitive Decline ◽  
White Matter Degeneration ◽  
Diffusion Tensor Imaging Study

scholarly journals White matter hyperintensity microstructure in amyloid dysmetabolism

2016 ◽  
Vol 37 (1) ◽  
pp. 356-365 ◽  
Author(s):  
Lisa F Kalheim ◽  
Atle Bjørnerud ◽  
Tormod Fladby ◽  
Kjetil Vegge ◽  
Per Selnes
Keyword(s):  
White Matter ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Amyloid Β ◽  
White Matter Hyperintensity ◽  
Subjective Cognitive Decline ◽  
Amyloid Β Peptide ◽  
Amyloid Accumulation ◽  
Vascular Origin

Accumulating evidence suggests associations between cerebrovascular disease (CVD) and Alzheimer’s disease (AD). White matter hyperintensities of presumed vascular origin (WMHs) are increased in subjects with mild cognitive impairment (MCI) and AD, but the exact pathomechanistic link is unknown. The current study investigated effects of amyloid dysmetabolism on the microstructure of WMHs in subjects with MCI or subjective cognitive decline ( N = 51), dichotomized according to pathological or normal levels of amyloid-β peptide (Aβ42) in cerebrospinal fluid (CSF). Thirty-one subjects with low CSF Aβ42 (Aβ+) and 20 subjects with normal CSF Aβ42 (Aβ−) were assessed with magnetic resonance diffusion tensor imaging (DTI), and fractional anisotropy (FA), radial diffusivity (DR), axial diffusivity (DA), and mean diffusivity (MD) were determined. There were no significant differences in WMH volume or distribution between the groups, and neither age nor WMH volume had significant impact on the DTI indices. Nevertheless, there were significantly higher DA, DR, and MD in WMHs in Aβ+ relative to Aβ−; however, no differences in FA were found. The present results suggest that amyloid accumulation is associated with impaired structural integrity (e.g. relating to more extensive demyelination and loss of axons) in WMHs putatively adding to effects of ischemia.

scholarly journals Dose-dependent degeneration of non-cancerous brain tissue in post-radiotherapy patients: A diffusion tensor imaging study

2019 ◽  
Author(s):  
Szabolcs David ◽  
Hamed Y. Mesri ◽  
Victor A. Bodiut ◽  
Steven H. J. Nagtegaal ◽  
Hesham Elhalawani ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Cognitive Decline ◽  
Brain Tissue ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Imaging Study ◽  
Relative Sensitivity ◽  
Frontal Pole ◽  
Regional Variability

AbstractBackground and purposeRadiation-induced changes in brain tissue may relate to post-radiotherapy (RT) cognitive decline. Our aim is to investigate changes of the brain microstructural properties after exposure to radiation during clinical protocols of RT using diffusion MRI (dMRI).Methods and MaterialsThe susceptibility of tissue changes to radiation was investigated in a clinically heterogenic cohort (age, pathology, tumor location, type of surgery) consisting of 121 scans of 18 patients (10 females). The imaging dataset included 18 planning CTs and 103 dMRI scans (range 2-14, median = 6 per patient) assessing pre-operative, post-operative pre-RT and post-RT states. Diffusion tensor imaging (DTI) metrics were estimated from all scans for a region-of-interest based linear relation analysis between mean dose and change in DTI metrics, while partial volume effects were regressed out.ResultsThe largest regional dose dependency with mean diffusivity appear in the white matter of the frontal pole in the left hemisphere by an increase of 2.61 %/(Gy x year). Full brain-wise, pooled results for white matter show fractional anisotropy to decrease by 0.85 %/(30Gy x year); mean diffusivity increase by 9.17 %/(30Gy x year); axial diffusivity increase by 7.30%/(30Gy x year) and radial diffusivity increases by 10.63%/(30Gy x year).ConclusionsWhite matter is susceptible to radiation with some regional variability where diffusivity metrics demonstrate the largest relative sensitivity. This suggests that dMRI is a promising tool in assessing microstructural changes after RT, which can help in understanding treatment-induced cognitive decline.

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