scholarly journals The Relationships Between Lipid Accumulation Product Levels and Cognitive Decline Over 4 Years in a Rural Area of Xi’an, China

2021 ◽  
Vol 13 ◽  
Author(s):  
Yanyu Wang ◽  
Shan Wei ◽  
Rong Zhou ◽  
Suhang Shang ◽  
Liangjun Dang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cognitive Impairment ◽  
Cognitive Decline ◽  
Mmse Score ◽  
Blood Lipid ◽  
Normal Blood Pressure ◽  
Lipid Levels ◽  
Lipid Accumulation Product ◽  
Blood Lipid Levels

Background and Aims: The relationships between blood lipid levels and obesity and cognitive impairment have not been fully determined. Considering that the lipid accumulation product (LAP) is a composite index of blood lipid levels and obesity, we investigated the relationships between LAP levels at baseline and cognitive decline over 4 years.Methods: A total of 983 subjects (≥40 years) from a longitudinal cohort in a village of Xi’an, China, who completed the baseline survey were followed-up for 4 years. All participants underwent face-to-face interviews and cognitive assessments at baseline and at the 4-year follow-up. The Mini-Mental State Examination (MMSE) was used to assess cognitive function, and an MMSE score dropping ≥ 2 points from baseline was defined as cognitive decline. The relationships between LAP and cognitive decline were analyzed by linear regression models.Results: During the 4-year follow-up, 172 patients exhibited cognitive decline (17.5%). Univariate analysis showed that the rate of change in MMSE score was significantly different between the low-LAP group and the high-LAP group (t = −2.26, p = 0.024). Multiple linear regression indicated that a high LAP was positively associated with cognitive decline (β = 0.564, p = 0.012). Stratified multivariate analysis showed that LAP was positively associated with cognitive decline in the normal blood pressure female subgroup (β = 1.29, p = 0.002) but not in the high blood pressure group or the male group.Conclusions: High LAP is associated with cognitive decline in females with normal blood pressure but not in those with high blood pressure or males. This indicates that the relationships between blood lipid levels and obesity and cognitive impairment may be affected by blood pressure and sex.

scholarly journals Association between blood lipid levels and carotid intima-media thickness in Shanghai urban population

2013 ◽  
Vol 1 (1) ◽  
pp. 36-39
Author(s):  
Ya-Ya Guan ◽  
Mian Li ◽  
Xiao-Ou Chen ◽  
Wei Yang ◽  
Ming-Ming Tang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Urban Population ◽  
Intima Media Thickness ◽  
Blood Lipid ◽  
Carotid Intima Media Thickness ◽  
Normal Group ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Media Thickness ◽  
Blood Lipid Levels

Abstract Objective: The objective of the following study is to investigate the relationship between blood lipid levels and carotid intima-media thickness (CIMT) in Shanghai urban population. Materials and Methods: A total of 2504 residents over 40 years old in Jiading District of Shanghai municipality were divided into two groups in terms of the CIMT value 0.7 mm: Thickened group (n = 478) and normal group (n = 2026). All the patients received examinations of height, weight, waist, blood pressure, blood lipid level, hepatic and renal function, oral glucose tolerance test and carotid artery B-ultrasonography. Results: In comparison with those in CIMT normal group, the proportion of males, ages, body mass index, systolic blood pressure and levels of fast blood glucose, total cholesterol (TC), triglyceride (TG) and lowdensity lipoprotein cholesterol (LDL-C) were increased, but the levels of fast insulin were decreased (all P < 0.05). The risks of CIMT thickness were elevated by 19% and 25% as every increase in the standard deviation of the TC and LDL-C levels respectively (95% of confidence interval [CI] 1.08-1.31; 95% CI 1.13-1.37). Statistical analysis showed a significant correlation between CIMT thickness and TC/LDL-C. The levels of TG and high-density lipoprotein cholesterol were not associated with CIMT thickness. Conclusions: Levels of blood TC and LDL-C have significant correlations with the CIMT thickness in Shanghai urban population.

Trends in blood lipid levels, blood pressure, alcohol and smoking habits from 1985 to 2002: results from INTERGENE and GOT-MONICA

2005 ◽  
Vol 12 (2) ◽  
pp. 115-125 ◽  
Author(s):  
Christina M. Berg ◽  
Lauren Lissner ◽  
Nibia Aires ◽  
Georgios Lappas ◽  
Kjell Tor??n ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Lipid ◽  
Smoking Habits ◽  
Lipid Levels ◽  
Blood Lipid Levels

Blood pressure and blood lipid levels among vegetarian, semi-vegetarian, and non-vegetarian native Africans

1998 ◽  
Vol 31 (7) ◽  
pp. 545-549 ◽  
Author(s):  
Ademola Adekunle Famodu ◽  
Odutola Osilesi ◽  
Yetunde Olawumi Makinde ◽  
Olusoga Adewale Osonuga
Keyword(s):  
Blood Pressure ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Blood Lipid Levels

Does cisplatin-based chemotherapy effect on blood lipid levels of patients with germ cell testicular tumor in long-term follow-up?

2011 ◽  
Vol 43 (4) ◽  
pp. 1095-1100 ◽  
Author(s):  
Gokhan Koc ◽  
Taner Rauf Divrik ◽  
Nuri Unlu ◽  
Volkan Bulut ◽  
Ferruh Zorlu
Keyword(s):  
Germ Cell ◽  
Testicular Tumor ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Long Term Follow Up ◽  
Blood Lipid Levels

scholarly journals Effect of cigarette smoking on smoking biomarkers, blood pressure and blood lipid levels among Sri Lankan male smokers

2021 ◽  
pp. postgradmedj-2021-141016
Author(s):  
Prasanna Herath ◽  
Savithri Wimalasekera ◽  
Thamara Amarasekara ◽  
Manoj Fernando ◽  
Sue Turale
Keyword(s):  
Blood Pressure ◽  
Sri Lanka ◽  
Cigarette Smoking ◽  
Negative Correlation ◽  
Density Lipoprotein ◽  
Blood Lipid ◽  
Lipoprotein Cholesterol ◽  
Lipid Levels ◽  
Positive Correlation ◽  
Blood Lipid Levels

Study purposeThe aim of this study was to determine the fractional exhaled nitric oxide (FeNO) levels, exhaled breath carbon monoxide (eCO) levels, blood pressure, blood lipid levels between smokers and non-smokers and to determine the association of smoking intensity with the above parameters.MethodsThis descriptive study was conducted in selected periurban areas of the Colombo District, Sri Lanka. Adult male current tobacco smokers (n=360), aged between 21 and 60 years were studied and compared with anthropometrically matched male non-smokers (n=180). Data were collected by interviewer-administered questionnaire, clinical assessment and measurement of FeNO by FENO monitor and eCO bySmokerlyser.ResultsSmokers had significantly lower mean FeNO levels and higher mean eCO values compared with non-smokers. Presentation of palpitations was higher among the smokers and a significantly positive correlation was identified between palpitations and eCO levels. There was a significantly positive correlation between the systolic blood pressure of smokers with the duration of smoking (DS), Brinkman Index (BI), Body Mass Index (BMI) and there was a significantly negative correlation with FeNO levels. The mean arterial pressure was positively correlated with the DS, BI and BMI. There was a significantly negative correlation between FeNO and the number of cigarettes smoked per day, DS and BI of smokers. Significantly higher total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), very LDL-C, TC: HDL ratio and low high density lipoprotein cholesterol (HDL-C) level was observed among smokers compared with the non-smokers.ConclusionsTobacco smoking was found to impact blood pressure and serum lipid levels thus enhancing the cardiovascular risk among smokers. The levels of eCO and FeNO are useful biomarkers for determining the intensity of smoking. The results indicate the necessity for urgent measures to stop cigarette smoking in Sri Lanka.

scholarly journals Comparison of Renal Effects of Ezetimibe–Statin Combination versus Statin Monotherapy: A Propensity-Score-Matched Analysis

2020 ◽  
Vol 9 (3) ◽  
pp. 798
Author(s):  
Jaehyun Bae ◽  
Namki Hong ◽  
Byung-Wan Lee ◽  
Eun Seok Kang ◽  
Bong-Soo Cha ◽  
...  
Keyword(s):  
Renal Function ◽  
Propensity Score ◽  
Serum Creatinine ◽  
Blood Lipid ◽  
Renal Outcome ◽  
Lipid Levels ◽  
Beneficial Effects ◽  
Statin Monotherapy ◽  
Blood Lipid Levels

Neither lowering of blood lipid levels nor treatment with statins definitively improves renal outcomes. Ezetimibe, a non-statin antilipidemic agent, is known to not only decrease blood lipid levels but also reduce inflammatory response and activate autophagy. We evaluated the effect of adding ezetimibe to a statin on renal outcome compared with statin monotherapy by analyzing longitudinal data of 4537 patients treated with simvastatin 20 mg plus ezetimibe 10 mg (S + E) or simvastatin 20 mg alone (S) for more than 180 days. A propensity-score-based process was used to match baseline characteristics, medical history, and estimated glomerular filtration rate (eGFR) between S + E and S groups. Changes in serum creatinine and incidence of renal events, defined as doubling of serum creatinine to ≥1.5 mg/dL or occurrence of end-stage renal disease after the first day of treatment initiation, were compared between the groups. Among 3104 well-matched patients with a median follow-up of 4.2 years, the S + E group showed a significantly lower risk of renal events than the S group (hazard ratio 0.58; 95% CI 0.35-0.95, P = 0.032). In addition, the S + E group tended to preserve renal function compared with the S group throughout follow-up, as assessed by serum creatinine changes (P-values for time–group interactions <0.001). These data support the beneficial effects on renal function when combining ezetimibe with a statin.

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