scholarly journals White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression

2021 ◽  
Vol 15 ◽  
Author(s):  
Rita Vieira ◽  
Ana Coelho ◽  
Joana Reis ◽  
Carlos Portugal-Nunes ◽  
Ricardo Magalhães ◽  
...  
Keyword(s):  
White Matter ◽  
Major Depression ◽  
Magnetic Resonance ◽  
Treatment Response ◽  
Diffusion Tensor ◽  
Antidepressant Treatment ◽  
Antidepressant Response ◽  
Superior Longitudinal Fasciculus ◽  
White Matter Microstructure ◽  
Paroxetine Treatment

More than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, there has been a focus on studying neural biomarkers associated with antidepressant response. Diffusion tensor imaging measures have shown a promising role as predictors of antidepressant response by pointing to pretreatment differences in the white matter microstructural integrity between future responders and non-responders to different pharmacotherapies. Therefore, the aim of the present study was to explore whether response to paroxetine treatment was associated with differences in the white matter microstructure at baseline. Twenty drug-naive patients diagnosed with major depressive disorder followed a 6- to 12-week treatment with paroxetine. All patients completed magnetic resonance brain imaging and a clinical assessment at baseline and 6–12 weeks after treatment. Whole-brain tract-based spatial statistics was used to explore differences in white matter microstructural properties estimated from diffusion magnetic resonance imaging. Voxel-wise statistical analysis revealed a significant increase in fractional anisotropy and a decrease in radial diffusivity in forceps minor and superior longitudinal fasciculus in responders compared to non-responders. Thus, alterations in white matter integrity, specifically in forceps minor and the superior longitudinal fasciculus, are associated with paroxetine treatment response. These findings pave the way for personalized treatment strategies in major depression.

scholarly journals Thyrotropin, but not a polymorphism in type II deiodinase, predicts response to paroxetine in major depression

2006 ◽  
Vol 154 (6) ◽  
pp. 819-825 ◽  
Author(s):  
Jantien P Brouwer ◽  
Bente C Appelhof ◽  
Robin P Peeters ◽  
Witte J G Hoogendijk ◽  
Jochanan Huyser ◽  
...  
Keyword(s):  
Major Depression ◽  
Treatment Response ◽  
Antidepressant Treatment ◽  
Type Ii ◽  
Lower Serum ◽  
Dsm Iv ◽  
Hpt Axis ◽  
The Brain ◽  
Paroxetine Treatment ◽  
Serum Tsh

Objective: The determinants of response to antidepressant treatment in major depression are unknown at present. The aim of the present study was to establish whether response is predicted by Hypothalamus–Pituitary–Thyroid (HPT) axis parameters or by a recently discovered polymorphism in the enzyme type II deiodinase (DII), which catalyzes the production of T3 in the brain. Design: We analyzed prediction of response to paroxetine treatment by calculating response rates per tertile of HPT-axis parameters and per DII genotype. Methods: Ninety-eight outpatients with major depression (DSM-IV) were included. Serum concentrations of TSH, FT4 and delta TSH in a DEX/CRH-TRH test were measured. In addition, the presence of a polymorphism in the DII sequence (Thr92Ala) was determined. Results: The overall treatment response was 48 of 98 patients (49%). After exclusion of patients with subclinical hypothyroidism and/or TPO antibodies (n = 16), higher serum TSH significantly predicted response (response rate per tertile from low to high TSH: 36%, 42%, and 67%). Heterozygous patients for the DII polymorphism (44%) had slightly lower serum TSH (P = 0.03) as compared to patients with the wild-type DII (47%). The polymorphism was unrelated to treatment response. Conclusion: Higher serum TSH was associated with response to paroxetine in patients with major depression.

Accuracy of diffusion tensor magnetic resonance imaging tractography assessed using intraoperative subcortical stimulation mapping and magnetic source imaging

2007 ◽  
Vol 107 (3) ◽  
pp. 488-494 ◽  
Author(s):  
Jeffrey I. Berman ◽  
Mitchel S. Berger ◽  
Sungwon Chung ◽  
Srikantan S. Nagarajan ◽  
Roland G. Henry
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Fiber Tracking ◽  
Bipolar Electrode ◽  
Source Imaging ◽  
Magnetic Source Imaging ◽  
Motor Pathway ◽  
Magnetic Source ◽  
Subcortical Stimulation

Object Resecting brain tumors involves the risk of damaging the descending motor pathway. Diffusion tensor (DT)–imaged fiber tracking is a noninvasive magnetic resonance (MR) technique that can delineate the subcortical course of the motor pathway. The goal of this study was to use intraoperative subcortical stimulation mapping of the motor tract and magnetic source imaging to validate the utility of DT-imaged fiber tracking as a tool for presurgical planning. Methods Diffusion tensor-imaged fiber tracks of the motor tract were generated preoperatively in nine patients with gliomas. A mask of the resultant fiber tracks was overlaid on high-resolution T1- and T2-weighted anatomical MR images and used for stereotactic surgical navigation. Magnetic source imaging was performed in seven of the patients to identify functional somatosensory cortices. During resection, subcortical stimulation mapping of the motor pathway was performed within the white matter using a bipolar electrode. Results A total of 16 subcortical motor stimulations were stereotactically identified in nine patients. The mean distance between the stimulation sites and the DT-imaged fiber tracks was 8.7 ±3.1 mm (±standard deviation). The measured distance between subcortical stimulation sites and DT-imaged fiber tracks combines tracking technique errors and all errors encountered with stereotactic navigation. Conclusions Fiber tracks delineated using DT imaging can be used to identify the motor tract in deep white matter and define a safety margin around the tract.

Altered White Matter Microstructure in Adolescents With Major Depression: A Preliminary Study

2010 ◽  
Vol 49 (2) ◽  
pp. 173-183.e1 ◽  
Author(s):  
Kathryn R. Cullen ◽  
Bonnie Klimes-Dougan ◽  
Ryan Muetzel ◽  
Bryon A. Mueller ◽  
Jazmin Camchong ◽  
...  
Keyword(s):  
White Matter ◽  
Major Depression ◽  
White Matter Microstructure ◽  
Preliminary Study

Diffusion tensor magnetic resonance imaging tractographic analysis of slMFB DBS in major depression

2017 ◽  
Vol 10 (2) ◽  
pp. 523-524
Author(s):  
V.A. Coenen ◽  
T.E. Schlaepfer ◽  
B. Bewernick ◽  
J. Bostroem ◽  
E. Hattingen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Major Depression ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Resonance Imaging

scholarly journals Structural disconnectivity in schizophrenia: a diffusion tensor magnetic resonance imaging study

2003 ◽  
Vol 182 (5) ◽  
pp. 439-443 ◽  
Author(s):  
J. Burns ◽  
D. Job ◽  
M. E. Bastin ◽  
H. Whalley ◽  
T. Macgillivray ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Fractional Anisotropy ◽  
Structural Integrity ◽  
Diffusion Tensor ◽  
Uncinate Fasciculus ◽  
Arcuate Fasciculus ◽  
Resonance Imaging ◽  
White Matter Tracts

BackgroundThere is growing evidence that schizophrenia is a disorder of cortical connectivity Specifically, frontotemporal and frontoparietal connections are thought to be functionally impaired. Diffusion tensor magnetic resonance imaging (DT–MRI) is a technique that has the potential to demonstrate structural disconnectivity in schizophrenia.AimsTo investigate the structural integrity of frontotemporal and frontoparietal white matter tracts in schizophrenia.MethodThirty patients with DSM–IV schizophrenia and thirty matched control subjects underwent DT–MRI and structural MRI. Fractional anisotropy – an index of the integrity of white matter tracts – was determined in the uncinate fasciculus, the anterior cingulum and the arcuate fasciculus and analysed using voxel-based morphometry.ResultsThere was reduced fractional anisotropy in the left uncinate fasciculus and left arcuate fasciculus in patients with schizophrenia compared with controls.ConclusionsThe findings of reduced white matter tract integrity in the left uncinate fasciculus and left arcuate fasciculus suggest that there is frontotemporal and frontoparietal structural disconnectivity in schizophrenia.

Sign in / Sign up

Export Citation Format

Share Document