Whole-Brain Mapping the Direct Inputs of Dorsal and Ventral CA1 Projection Neurons

The CA1, an important subregion of the hippocampus, is anatomically and functionally heterogeneous in the dorsal and ventral hippocampus. Here, to dissect the distinctions between the dorsal (dCA1) and ventral CA1 (vCA1) in anatomical connections, we systematically analyzed the direct inputs to dCA1 and vCA1 projection neurons (PNs) with the rabies virus-mediated retrograde trans-monosynaptic tracing system in Thy1-Cre mice. Our mapping results revealed that the input proportions and distributions of dCA1 and vCA1 PNs varied significantly. Inside the hippocampal region, dCA1 and vCA1 PNs shared the same upstream brain regions, but with distinctive distribution patterns along the rostrocaudal axis. The intrahippocampal inputs to the dCA1 and vCA1 exhibited opposite trends, decreasing and increasing gradually along the dorsoventral axis, respectively. For extrahippocampal inputs, dCA1 and vCA1 shared some monosynaptic projections from certain regions such as pallidum, striatum, hypothalamus, and thalamus. However, vCA1, not dCA1, received innervations from the subregions of olfactory areas and amygdala nuclei. Characterization of the direct input networks of dCA1 and vCA1 PNs may provide a structural basis to understand the differential functions of dCA1 and vCA1.

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Neuro-Clinical Signatures of Language Impairments: A Theoretical Framework for Function-to-structure Mapping in Clinics

Current Topics in Medicinal Chemistry ◽

10.2174/1568026620666200302111130 ◽

2020 ◽

Vol 20 (9) ◽

pp. 800-811 ◽

Cited By ~ 2

Author(s):

Ferath Kherif ◽

Sandrine Muller

Keyword(s):

Brain Mapping ◽

Theoretical Framework ◽

Brain Regions ◽

Language Impairments ◽

Structure Mapping ◽

Language Functions ◽

The Past ◽

Language Recovery ◽

The Brain ◽

Bow Tie

In the past decades, neuroscientists and clinicians have collected a considerable amount of data and drastically increased our knowledge about the mapping of language in the brain. The emerging picture from the accumulated knowledge is that there are complex and combinatorial relationships between language functions and anatomical brain regions. Understanding the underlying principles of this complex mapping is of paramount importance for the identification of the brain signature of language and Neuro-Clinical signatures that explain language impairments and predict language recovery after stroke. We review recent attempts to addresses this question of language-brain mapping. We introduce the different concepts of mapping (from diffeomorphic one-to-one mapping to many-to-many mapping). We build those different forms of mapping to derive a theoretical framework where the current principles of brain architectures including redundancy, degeneracy, pluri-potentiality and bow-tie network are described.

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Rabies virulence: effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein.

Journal of Virology ◽

10.1128/jvi.53.3.926-934.1985 ◽

1985 ◽

Vol 53 (3) ◽

pp. 926-934 ◽

Cited By ~ 241

Author(s):

I Seif ◽

P Coulon ◽

P E Rollin ◽

A Flamand

Keyword(s):

Rabies Virus ◽

Antigenic Site ◽

Sequence Characterization

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Connectivity characterization of the mouse basolateral amygdalar complex

Nature Communications ◽

10.1038/s41467-021-22915-5 ◽

2021 ◽

Vol 12 (1) ◽

Author(s):

Houri Hintiryan ◽

Ian Bowman ◽

David L. Johnson ◽

Laura Korobkova ◽

Muye Zhu ◽

...

Keyword(s):

Granular Cell ◽

Cell Types ◽

Projection Neurons ◽

Cell Type ◽

Connectivity Map ◽

Analysis Techniques ◽

Domain Specific ◽

Cell Type Specific ◽

Unique Domain

AbstractThe basolateral amygdalar complex (BLA) is implicated in behaviors ranging from fear acquisition to addiction. Optogenetic methods have enabled the association of circuit-specific functions to uniquely connected BLA cell types. Thus, a systematic and detailed connectivity profile of BLA projection neurons to inform granular, cell type-specific interrogations is warranted. Here, we apply machine-learning based computational and informatics analysis techniques to the results of circuit-tracing experiments to create a foundational, comprehensive BLA connectivity map. The analyses identify three distinct domains within the anterior BLA (BLAa) that house target-specific projection neurons with distinguishable morphological features. We identify brain-wide targets of projection neurons in the three BLAa domains, as well as in the posterior BLA, ventral BLA, posterior basomedial, and lateral amygdalar nuclei. Inputs to each nucleus also are identified via retrograde tracing. The data suggests that connectionally unique, domain-specific BLAa neurons are associated with distinct behavior networks.

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Physical Characterization of Rabies Virus Haemagglutinin

Journal of General Virology ◽

10.1099/0022-1317-3-2-289 ◽

1968 ◽

Vol 3 (2) ◽

pp. 289-293 ◽

Cited By ~ 13

Author(s):

F. A. Murphy ◽

P. E. Halonen ◽

G. W. Gary ◽

D. R. Reese

Keyword(s):

Rabies Virus ◽

Physical Characterization ◽

Virus Haemagglutinin

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Characterization of rabies virus from a human case in Nepal

Archives of Virology ◽

10.1007/s00705-010-0868-9 ◽

2011 ◽

Vol 156 (4) ◽

pp. 681-684 ◽

Cited By ~ 8

Author(s):

G. R. Pant ◽

D. L. Horton ◽

M. Dahal ◽

J. N. Rai ◽

S. Ide ◽

...

Keyword(s):

Rabies Virus ◽

Human Case

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Molecular Characterization of Cryptically Circulating Rabies Virus from Ferret Badgers, Taiwan

Emerging Infectious Diseases ◽

10.3201/eid2005.131389 ◽

2014 ◽

Vol 20 (5) ◽

pp. 790-798 ◽

Cited By ~ 32

Author(s):

Hue-Ying Chiou ◽

Chia-Hung Hsieh ◽

Chian-Ren Jeng ◽

Fang-Tse Chan ◽

Hurng-Yi Wang ◽

...

Keyword(s):

Molecular Characterization ◽

Rabies Virus

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Characterization of the Equilibrium between the Native and Fusion-Inactive Conformation of Rabies Virus Glycoprotein Indicates That the Fusion Complex Is Made of Several Trimers

Virology ◽

10.1006/viro.2002.1429 ◽

2002 ◽

Vol 297 (1) ◽

pp. 128-135 ◽

Cited By ~ 79

Author(s):

Stéphane Roche ◽

Yves Gaudin

Keyword(s):

Rabies Virus ◽

Inactive Conformation ◽

Rabies Virus Glycoprotein ◽

Virus Glycoprotein

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Characterization of conformation-specific monoclonal antibodies against rabies virus nucleoprotein

Archives of Virology ◽

10.1007/s00705-010-0709-x ◽

2010 ◽

Vol 155 (8) ◽

pp. 1187-1192 ◽

Cited By ~ 14

Author(s):

Yan Jiang ◽

Yonghuang Luo ◽

Frank Michel ◽

Robert J. Hogan ◽

Ying He ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Rabies Virus

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Characterization of Each St and Y Genome Chromosome of Roegneria grandis Based on Newly Developed FISH Markers

Cytogenetic and Genome Research ◽

10.1159/000515623 ◽

2021 ◽

pp. 213-222

Author(s):

Dandan Wu ◽

Xiaoxia Zhu ◽

Lu Tan ◽

Haiqin Zhang ◽

Lina Sha ◽

...

Keyword(s):

Structural Changes ◽

Distribution Patterns ◽

Proximal Region ◽

Genome Chromosome ◽

High Affinity ◽

Complete Set ◽

Genome Analyses ◽

First Time ◽

Homoeologous Chromosomes

The genera of the tribe Triticeae (family Poaceae), constituting many economically important plants with abundant genetic resources, carry genomes such as St, H, P, and Y. The genome symbol of Roegneria C. Koch (Triticeae) is StY. The St and Y genomes are crucial in Triticeae, and tetraploid StY species participate extensively in polyploid speciation. Characterization of St and Y nonhomologous chromosomes in StY-genome species could help understand variation in the chromosome structure and differentiation of StY-containing species. However, the high genetic affinity between St and Y genome and the deficiency of a complete set of StY nonhomologous probes limit the identification of St and Y genomes and variation of chromosome structures among Roegneria species. We aimed to identify St- and Y-enhanced repeat clusters and to study whether homoeologous chromosomes between St and Y genomes could be accurately identified due to high affinity. We employed comparative genome analyses to identify St- and Y-enhanced repeat clusters and generated a FISH-based karyotype of R. grandis (Keng), one of the taxonomically controversial StY species, for the first time. We explored 4 novel repeat clusters (StY_34, StY_107, StY_90, and StY_93), which could specifically identify individual St and Y nonhomologous chromosomes. The clusters StY_107 and StY_90 could identify St and Y addition/substitution chromosomes against common wheat genetic backgrounds. The chromosomes V_St, VII_St, I_Y, V_Y, and VII_Y displayed similar probe distribution patterns in the proximal region, indicating that the high affinity between St and Y genome might result from chromosome rearrangements or transposable element insertion among V_St/Y, VII_St/Y, and I_Y chromosomes during allopolyploidization. Our results can be used to employ FISH further to uncover the precise karyotype based on colinearity of Triticeae species by using the wheat karyotype as reference, to analyze diverse populations of the same species to understand the intraspecific structural changes, and to generate the karyotype of different StY-containing species to understand the interspecific chromosome variation.

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