scholarly journals Physical Activity Improves Anxiety and Apathy in Early Parkinson's Disease: A Longitudinal Follow-Up Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Samuel Yong-Ern Ng ◽  
Nicole Shuang-Yu Chia ◽  
Mirza Masoom Abbas ◽  
Ehsan Seyed Saffari ◽  
Xinyi Choi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
The Elderly ◽  
Attention And Memory ◽  
Early Parkinson’S Disease ◽  
Baseline Physical Activity

Objective: In a prospective study, we investigated the association between physical activity and various motor, non-motor outcomes, and quality of life in early Parkinson's disease (PD) participants in the PD Longitudinal Singapore Study.Background: Prospective studies that examined the association between physical activity and motor and non-motor domains in early PD are lacking.Methods: 121 PD participants were followed-up prospectively to evaluate the association of physical activity with various symptom domains. The Physical Activity Scale for the Elderly (PASE) was used to measure physical activity annually. PD-related symptoms were categorized by motor, non-motor, and quality of life measures. Multivariate regression with gain score analysis was performed to understand the association of baseline PASE scores with the change of each variable at 1-year follow-up.Results: Higher baseline PASE scores (greater activity) were associated with a younger age, lower MDS-UPDRS motor scores, a smaller levodopa equivalent daily dose, better attention and memory scores, and better QoL. Activity scores in early PD declined on follow-up. Multivariate analysis revealed higher baseline physical activity to be associated with decreased anxiety and apathy scores at 1-year follow-up, after adjusting for demographic variables and medications.Conclusion: We demonstrated that higher baseline physical activity was associated with improved anxiety and apathy symptoms in early PD over a 1-year period.

scholarly journals Physical activity benefits the elderly with Parkinson’s disease

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Lee
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Physical Activity Intervention ◽  
The Elderly ◽  
Negative Effect ◽  
Effect Of Pd

Abstract Background Growing number of ageing population adds to the increase in the number of the patients with Parkinson's disease (PD). PD is an idiopathic and progressive disease that significantly affects patients' daily activities and quality of life. The current study sought to explore the role of physical activity as correlates of coping strategies for the elderly with PD. Methods We employed a four-year follow-up study design using data drawn from the Survey of Health Ageing and Retirement in Europe (SHARE) - waves 4 and 6. A total of 421 who ever diagnosed or currently having PD (Wave 4) were followed-up (Wave 6). Cross-lagged associations were examined between self-rated health, limits of daily activities, psychological distress, CASP - quality of life scale (Control, Autonomy, Self-realization, Pleasure), and life satisfaction. A path model was developed to examine if moderate to vigorous physical activities mitigated negative effect of PD. Results ANOVA showed that well-being index in the older adults with PD decreased at follow-up point across the measured variables, self-rated health (p < .001), limits of daily activity (p < .001), depression (p < .001), loneliness (p < .001), CASP (p < .001) and life satisfaction (p < .001) after controlling for socio-demographic and other health variables. Moderate to vigorous level of physical activity appeared to significantly mitigate the negative effect of PD. Conclusions In order to improve the quality of life among the elderly with PD, multilayer intervention should be coupled with the medical treatment. Public health should design and implement enduring rehabilitation program and adaptive physical activity intervention that help psychological and behavioral adaptation process to chronic illness for Parkinson patients. Mobility assistance services or home care products can relieve the difficulties to perform activities of daily living of the elderly with Parkinson's disease. Key messages Parkinson patients are more likely to experience difficulties to perform activities of daily living. Physical activity intervention can enhance living of the elderly with Parkinson’s disease.

scholarly journals Extradural Motor Cortex Stimulation in Parkinson’s Disease: Long-Term Clinical Outcome

2021 ◽  
Vol 11 (4) ◽  
pp. 416
Author(s):  
Carla Piano ◽  
Francesco Bove ◽  
Delia Mulas ◽  
Enrico Di Stasio ◽  
Alfonso Fasano ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Cortex ◽  
Clinical Outcome ◽  
Motor Cortex Stimulation ◽  
Dopaminergic Therapy

Previous investigations have reported on the motor benefits and safety of chronic extradural motor cortex stimulation (EMCS) for patients with Parkinson’s disease (PD), but studies addressing the long-term clinical outcome are still lacking. In this study, nine consecutive PD patients who underwent EMCS were prospectively recruited, with a mean follow-up time of 5.1 ± 2.5 years. As compared to the preoperatory baseline, the Unified Parkinson’s Disease Rating Scale (UPDRS)-III in the off-medication condition significantly decreased by 13.8% at 12 months, 16.1% at 18 months, 18.4% at 24 months, 21% at 36 months, 15.6% at 60 months, and 8.6% at 72 months. The UPDRS-IV decreased by 30.8% at 12 months, 22.1% at 24 months, 25% at 60 months, and 36.5% at 72 months. Dopaminergic therapy showed a progressive reduction, significant at 60 months (11.8%). Quality of life improved by 18.0% at 12 months, and 22.4% at 60 months. No surgical complication, cognitive or behavioral change occurred. The only adverse event reported was an infection of the implantable pulse generator pocket. Even in the long-term follow-up, EMCS was shown to be a safe and effective treatment option in PD patients, resulting in improvements in motor symptoms and quality of life, and reductions in motor complications and dopaminergic therapy.

scholarly journals Influence of the COVID-19 Pandemic on Quality of Life of Patients with Parkinson’s Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Dengjun Guo ◽  
Bing Han ◽  
Yuqiang Lu ◽  
Chenling Lv ◽  
Xiaoling Fang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prevention And Control ◽  
Control Period ◽  
And Control ◽  
Disease Questionnaire ◽  
Gradual Release

Introduction. This study investigated the influence of lockdown during the 2019 coronavirus disease (COVID-19) pandemic on the quality of life of patients with Parkinson’s disease (PD). Methods. We conducted a questionnaire survey involving 113 patients with PD from Xihu District, Hangzhou, Zhejiang. During the epidemic prevention and control period (February 1 to March 31, 2020), patients enrolled were asked to fill out questionnaires, including the “COVID-19 Questionnaire for PD Patients during the Period of Epidemic Prevention and Control” and “39-item Parkinson’s Disease Questionnaire (PDQ-39).” During the phase of gradual release of epidemic prevention and control (April 1 to April 30, 2020), all patients were followed up again, and PDQ-39 questionnaires were completed. Results. The quality of life for patients during the period of epidemic prevention and control was worse than that after epidemic prevention and control (P < 0.001). The biggest problem that they faced was that they could not receive their doctor’s advice or guidance regularly. The quality of life of patients who had difficulty getting doctors’ guidance or those who changed their routine medication due to lockdown was even worse. Telemedicine was quite effective and efficient for patients to get doctors’ guidance during lockdown. Conclusions. The inconvenient treatment during the pandemic directly caused the aggravation of patients’ symptoms and the decline in their quality of life. It is suggested that social media (such as WeChat or Tencent QQ) are used for regular interactions and follow-up appointments for patients with inconvenient medical treatment.

Rasagiline improves quality of life in patients with early Parkinson's disease

2006 ◽  
Vol 21 (5) ◽  
pp. 616-623 ◽  
Author(s):  
Kevin M. Biglan ◽  
Steven Schwid ◽  
Shirley Eberly ◽  
Karen Blindauer ◽  
Stanley Fahn ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Early Parkinson’S Disease

IMPACT & TREATMENT OF NON-MOTOR SYMPTOMS IN EARLY PARKINSON'S DISEASE

2015 ◽  
Vol 86 (11) ◽  
pp. e4.80-e4
Author(s):  
Fahd Baig ◽  
Michael Lawton ◽  
Michal Rolinski ◽  
Claudio Ruffmann ◽  
Kannan Nithi ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Symptoms ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Non Motor Symptoms ◽  
Early Parkinson’S Disease

ObjectiveTo delineate treatment and quality of life of non-motor symptoms (NMS) in early Parkinson's disease (PD) and first-degree relatives.BackgroundNon-motor symptoms (NMS) are an important prodromal feature of Parkinson's disease (PD). However, their frequency, treatment rates and impact on health-related quality of life (HRQoL) in the early motor phase is unclear.Methods769 population-ascertained PD subjects within 3.5 years of diagnosis and 287 control subjects were assessed. Validated severity questionnaires were employed to assess NMS symptoms across the following domains: (1) neuropsychiatric (2) gastrointestinal (3) sleep (4) sensory (5) autonomic (6) sexual. Health related quality of life (HRQoL), functional status and management were also evaluated.ResultsNMS were common in early PD. More than half of the PD cases had hyposmia, pain, fatigue, sleep disturbance or urinary dysfunction. PD cases had worse HRQoL scores than controls (OR 4.1, p<0.001) with depression, anxiety and pain being stronger drivers than MDS-UPDRS motor scores. Quality of life is affected in early PD, although 23% of participants reported no problems. NMS were rarely treated in routine clinical practice.ConclusionsDespite their major impact on HRQoL, NMS are usually under-recognised and treated. The use of screening tools could improve recognition and treatment of NMS in early PD.

scholarly journals Mindfulness for Motor and Nonmotor Dysfunctions in Parkinson’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Nadeeka N. W. Dissanayaka ◽  
Farah Idu Jion ◽  
Nancy A. Pachana ◽  
John D. O’Sullivan ◽  
Rodney Marsh ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Controlled Trial ◽  
Nonparametric Tests ◽  
Life Questionnaire ◽  
Mindfulness Intervention

Background. Motor and nonmotor symptoms negatively influence Parkinson’s disease (PD) patients’ quality of life. Mindfulness interventions have been a recent focus in PD. The present study explores effectiveness of a manualized group mindfulness intervention tailored for PD in improving both motor and neuropsychiatric deficits in PD.Methods. Fourteen PD patients completed an 8-week mindfulness intervention that included 6 sessions. The Five Facet Mindfulness Questionnaire (FFMQ), Geriatric Anxiety Inventory, Hamilton Depression Rating Scale, PD Cognitive Rating Scale, Unified PD Rating Scale, PD Quality of Life Questionnaire, and Outcome Questionnaire (OQ-45) were administered before and after the intervention. Participants also completed the FFMQ-15 at each session. Gains at postassessment and at 6-month follow-up were compared to baseline using pairedt-tests and Wilcoxon nonparametric tests.Results. A significant increase in FFMQ-Observe subscale, a reduction in anxiety, depression, and OQ-45 symptom distress, an increase in PDCRS-Subcortical scores, and an improvement in postural instability, gait, and rigidity motor symptoms were observed at postassessment. Gains for the PDCRS were sustained at follow-up.Conclusion. The mindfulness intervention tailored for PD is associated with reduced anxiety and depression and improved cognitive and motor functioning. A randomised controlled trial using a large sample of PD patients is warranted.

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