scholarly journals Impact of Subthalamic Deep Brain Stimulation on Hyposmia in Patients With Parkinson's Disease Is Influenced by Constipation and Dysbiosis of Microbiota

2021 ◽  
Vol 12 ◽  
Author(s):  
Chao Li ◽  
Ying Hou ◽  
Xu Wang ◽  
Yue-xuan Li ◽  
Feng Li ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Therapeutic Effect ◽  
Brain Stimulation ◽  
Early Stage ◽  
Olfactory Function ◽  
Efficient Treatment ◽  
Qilu Hospital ◽  
Potential Factors ◽  
The Relationship ◽  
Deep Brain

Background: Non-motor symptoms in PD usually arise at very early stage and vary during the whole disease progression. Deep brain stimulation (DBS) is considered as a highly efficient treatment option for PD's motor function. However, the effect of DBS on NMS, especially hyposmia, has not been fully understood and the deep connection between different NMS such as hyposmia and constipation is still unknown.Objective: The objective of this study was to evaluate the therapeutic effect of DBS on hyposmia in PD patients with or without constipation and find potential factors which might influence the efficacy.Methods: A retrospective analysis of 65 PD patients accepted STN-DBS operation in Qilu Hospital during 2019–2020 were conducted to evaluate the exact therapeutic effect of DBS on hyposmia in PD. Sub-group analyses about the relationship between hyposmia and constipation were carried out. Analysis of flora in nasal mucosa was also conducted to evaluate the abundance and variety in different PD groups.Results: Our study showed that DBS had clearly improved olfactory function in Parkinson patients (P = 0.012) and subgroup analysis found that PD patients with constipation have lower olfactory function scores (25.27 ± 3.44 vs. 33.90 ± 6.633, p = 0.014) and worse improvement after DBS operation (ΔTDI 12.11 ± 3.2 vs. 8.78 ± 2.91, p = 0.0072). Analysis of flora indicated the obvious discrepancy on olfactory function scores and degree of improvement might be related to the abundance and dysbiosis of microbiota.Conclusion: In summary, this article presents a study on PD with hyposmia and constipation after DBS operation, explored the relationship between different NMS and offer a potential explanation on why PD patients with constipation usually have worse olfactory function for the less abundance and variety of microbiota.

scholarly journals Deep Brain Stimulation Effects on Olfactory Dysfunction of Parkinson’s Disease - A Meta-Analysis

2020 ◽  
Author(s):  
Chao Li ◽  
Xue-lian Chu ◽  
Min Tian ◽  
Feng Li ◽  
Shu-jun Xu ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Publication Bias ◽  
Therapeutic Effect ◽  
Brain Stimulation ◽  
Early Stage ◽  
Meta Analysis ◽  
Olfactory Function ◽  
Efficient Treatment ◽  
Stimulation Parameters ◽  
Deep Brain

Abstract Background: Non-motor symptoms in PD usually arise at very early stage and suffer the damage decades from diagnose. Deep brain stimulation (DBS) is considered as a highly efficient treatment option for PD’s motor function. However, the effect of DBS on NMS, especially hyposmia, has not been fully understood and there are contradictory data among different researches.Objective: The objective of this study was to evaluate the therapeutic effect of DBS on hyposmia in PD patients with a cohort study and identified whether the olfactory function scores influence the final surgery effect.Methods: A meta-analysis including six studies with 326 patients were conducted to evaluate the exact therapeutic effect of DBS on hyposmia in PD. Sub-group analyses based on sample size, gender, stimulation parameters were carried out to distinguish the difference. Sensitivity analysis was conducted to evaluate studies’ heterogeneity and stability. Potential publication bias were evaluated by Egger’s tests and the funnel plots.Results: Our study showed that DBS had clearly improved olfactory function in Parkinson patients (P < 0.0001) and the group heterogeneity as well as the publication bias advocate the convince of the result (Heterogeneity: Chi² = 6.39, df = 5 (P = 0.38); I² = 22%). Subgroup analysis also found that different groups of gender, education level or stimulation parameters have no obvious discrepancy on olfactory function improvement except age groups.Conclusion: In summary, this article summarize studies about DBS and hyposmia and offer evidences for the notion that DBS has authentic therapeutic value on the hyposmia in PD.

Effects of deep brain stimulation on sleep-wake disturbances in patients with Parkinson's disease: A narrative review

2021 ◽  
Vol 19 ◽  
Author(s):  
Yu Jin Jung ◽  
Han-Joon Kim ◽  
Sun Ha Paek ◽  
Beomseok Jeon
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Early Stage ◽  
Motor Symptoms ◽  
Specific Effects ◽  
The Impact ◽  
Non Motor Symptoms ◽  
Deep Brain

: Sleep-wake disturbances (SWD) are one of the most common non-motor symptoms in Parkinson's disease (PD) and can appear in the early stage even before the onset of motor symptoms. Deep brain stimulation (DBS) is an established treatment for the motor symptoms in patients with advanced PD. However, the effect of DBS on SWD and its specific mechanisms are not widely understood and remain controversial. In addition to the circuit-mediated direct effect, DBS may improve SWD by an indirect effect such as the resolution of nocturnal motor complications and a reduction of dopaminergic medication. Here, the authors review the recent literatures regarding the impact of DBS on SWD in patients with PD. Furthermore, the selection of the DBS targets and the specific effects of applying DBS to each target on SWD in PD are also discussed.

Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidus

2008 ◽  
Vol 109 (1) ◽  
pp. 130-132 ◽  
Author(s):  
Brigitte Biolsi ◽  
Laura Cif ◽  
Hassan El Fertit ◽  
Santiago Gil Robles ◽  
Philippe Coubes
Keyword(s):  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Movement Disorders ◽  
Huntington Disease ◽  
Internal Globus Pallidus ◽  
Efficient Treatment ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation is now accepted as a safe and efficient treatment for movement disorders including selected types of dystonia and dyskinesia. Very little, however, is known about its effect on other movement disorders, particularly for “choreic” movements. Huntington disease is a fatal autosomal-dominant neurodegenerative disorder characterized by movement disorders, progressive cognitive impairment, and psychiatric symptoms. Bilateral chronic stimulation of the internal globus pallidus was performed to control choreic movements in a 60-year-old man with a 10-year history of Huntington disease. Chronic deep brain stimulation resulted in remarkable improvement of choreic movements. Postoperative improvement was sustained after 4 years of follow-up with a marked improvement in daily quality of life.

Neuropsychological Effects of Deep Brain Stimulation in Subjects with Early Stage Parkinson's Disease in a Randomized Clinical Trial

2015 ◽  
Vol 5 (1) ◽  
pp. 151-163 ◽  
Author(s):  
Michael G. Tramontana ◽  
Anna L. Molinari ◽  
Peter E. Konrad ◽  
Thomas L. Davis ◽  
Scott A. Wylie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Randomized Clinical Trial ◽  
Brain Stimulation ◽  
Early Stage ◽  
Neuropsychological Effects ◽  
Deep Brain

scholarly journals Subthalamic nucleus deep brain stimulation in early stage Parkinson's disease

2014 ◽  
Vol 20 (7) ◽  
pp. 731-737 ◽  
Author(s):  
David Charles ◽  
Peter E. Konrad ◽  
Joseph S. Neimat ◽  
Anna L. Molinari ◽  
Michael G. Tramontana ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Early Stage ◽  
Deep Brain

Patient Perspectives on Deep Brain Stimulation Clinical Research in Early Stage Parkinson’s Disease

2017 ◽  
Vol 7 (1) ◽  
pp. 89-94 ◽  
Author(s):  
Lauren Heusinkveld ◽  
Mallory Hacker ◽  
Maxim Turchan ◽  
Madelyn Bollig ◽  
Christina Tamargo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Clinical Research ◽  
Brain Stimulation ◽  
Early Stage ◽  
Patient Perspectives ◽  
Deep Brain

scholarly journals Shaping reversibility? Long-term deep brain stimulation in dystonia: the relationship between effects on electrophysiology and clinical symptoms

Brain ◽  
2011 ◽  
Vol 134 (7) ◽  
pp. 2106-2115 ◽  
Author(s):  
D. Ruge ◽  
L. Cif ◽  
P. Limousin ◽  
V. Gonzalez ◽  
X. Vasques ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Clinical Symptoms ◽  
The Relationship ◽  
Deep Brain

scholarly journals A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effects

2021 ◽  
Vol 05 (02) ◽  
pp. 1-1
Author(s):  
Francesco Sciancalepore ◽  
◽  
Giulia Remoli ◽  
Leonardo Tariciotti ◽  
Giulia Sarti ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Early Stage ◽  
Case Reports ◽  
Biological Processes ◽  
Inclusion Criteria ◽  
Disease Modifying ◽  
Deep Brain

Deep-Brain Stimulation (DBS) is an important treatment option for the management of Parkinson’s disease (PD) and is a common symptomatic treatment. However, an increasing number of studies have examined the biological processes to assess if DBS can also modify the natural history of PD by acting on its pathophysiological mechanisms. Relevant literature published up to November 2020 was systematically searched on databases such as PubMed, ISI Web of Knowledge, Academic Search Index, and Science Citation Index. The following predefined inclusion criteria were applied to the full-text versions of the selected articles: i) recruiting and monitoring of PD subjects that were previously treated with DBS and ii) investigating the electrophysiological, biochemical, epigenetic, or neuroimaging effects of DBS. Studies focusing exclusively on motor and clinical changes were excluded. Reviews, case reports, studies on animal models, and computational studies were also not considered. Out of 2,960 records screened, 43 studies met the inclusion criteria. Only three studies described a potential disease-modifying effect of DBS. However, a wide heterogeneity was observed in the investigated biomarkers, and the design and methodological issues of several studies limited their ability to find potential disease-modifying features. Specifically, 60.4% of the trials followed-up subjects for no more than 1 year from the surgical intervention, and 67.4% observed patients with PD only once after DBS. Moreover, 64.2% of the studies enrolled late-stage PD patients. Most of the studies (88.4%) reported that DBS only had a symptomatic effect, with several of them showing some limitations in the study design and recruitment of patients. Further studies using shared biomarkers are encouraged to assess if and how DBS might affect the progression of PD. Based on the existing preclinical literature, prospective clinical trials examining the course of PD in early-stage patients are needed.

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