Abnormal Topology of the Structural Connectome in the Limbic Cortico-Basal-Ganglia Circuit and Default-Mode Network Among Primary Insomnia Patients

The two major brain networks, i.e. the default mode network (DMN) and the task positive network, typically reveal negative and variable connectivity in resting-state. In the present study, we examined whether the connectivity between the DMN and different components of the task positive network were modulated by other brain regions by using physiophysiological interaction (PPI) on resting-state functional magnetic resonance imaging data. Spatial independent component analysis was first conducted to identify components that represented networks of interest, including the anterior and posterior DMNs, salience, dorsal attention, left and right executive networks. PPI analysis was conducted between pairs of these networks to identify networks or regions that showed modulatory interactions with the two networks. Both network-wise and voxel-wise analyses revealed reciprocal positive modulatory interactions between the DMN, salience, and executive networks. Together with the anatomical properties of the salience network regions, the results suggest that the salience network may modulate the relationship between the DMN and executive networks. In addition, voxel-wise analysis demonstrated that the basal ganglia and thalamus positively interacted with the salience network and the dorsal attention network, and negatively interacted with the salience network and the DMN. The results demonstrated complex modulatory interactions among the DMNs and task positive networks in resting-state, and suggested that communications between these networks may be modulated by some critical brain structures such as the salience network, basal ganglia, and thalamus.

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Modulatory interactions between the default mode network and task positive networks in resting-state

10.7287/peerj.preprints.124 ◽

2014 ◽

Cited By ~ 1

Author(s):

Xin Di ◽

Bharat B. Biswal

Keyword(s):

Basal Ganglia ◽

Default Mode Network ◽

Resting State ◽

Brain Structures ◽

Brain Regions ◽

Salience Network ◽

Imaging Data ◽

Default Mode ◽

Task Positive Network ◽

And Task

The two major brain networks, i.e. the default mode network (DMN) and the task positive network, typically reveal negative and variable connectivity in resting-state. In the present study, we examined whether the connectivity between the DMN and different components of the task positive network were modulated by other brain regions by using physiophysiological interaction (PPI) on resting-state functional magnetic resonance imaging data. Spatial independent component analysis was first conducted to identify components that represented networks of interest, including the anterior and posterior DMNs, salience, dorsal attention, left and right executive networks. PPI analysis was conducted between pairs of these networks to identify networks or regions that showed modulatory interactions with the two networks. Both network-wise and voxel-wise analyses revealed reciprocal positive modulatory interactions between the DMN, salience, and executive networks. Together with the anatomical properties of the salience network regions, the results suggest that the salience network may modulate the relationship between the DMN and executive networks. In addition, voxel-wise analysis demonstrated that the basal ganglia and thalamus positively interacted with the salience network and the dorsal attention network, and negatively interacted with the salience network and the DMN. The results demonstrated complex modulatory interactions among the DMNs and task positive networks in resting-state, and suggested that communications between these networks may be modulated by some critical brain structures such as the salience network, basal ganglia, and thalamus.

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Modulatory Interactions between the Default Mode Network and Task Positive Networks in Resting-State

10.7287/peerj.preprints.124v1 ◽

2013 ◽

Author(s):

Xin Di ◽

Bharat B. Biswal

Keyword(s):

Basal Ganglia ◽

Functional Connectivity ◽

Default Mode Network ◽

Resting State ◽

Brain Networks ◽

Brain Regions ◽

Salience Network ◽

Imaging Data ◽

Default Mode ◽

Brain Functions

Communications between different brain systems are critical to support complex brain functions. Unlike generally high functional connectivity between brain regions from same system, functional connectivity between regions from different systems are more variable. In the present study, we examined whether the connectivity between different brain networks were modulated by other regions by using physiophysiological interaction (PPI) on resting-state functional magnetic resonance imaging data. Spatial independent component analysis was first conducted to identify the default mode network (DMN) and several task positive networks, including the salience, dorsal attention, left and right executive networks. PPI analysis was conducted between pairs of these networks to identify networks or regions that showed modulatory interactions with the two networks. Network-wise analysis revealed reciprocal modulatory interactions between the DMN, salience, and executive networks. Together with the anatomical properties of the salience network regions, the results suggest that the salience network may modulate the relationship between the DMN and executive networks. In addition, voxel-wise analysis demonstrated that the basal ganglia and thalamus positively interacted with the salience network and the dorsal attention network, and negatively interacted with the salience network and the DMN. The results demonstrated complex relationships among brain networks in resting-state, and suggested that between network communications of these networks may be modulated by some critical brain structures such as the salience network, basal ganglia, and thalamus.

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115. Functional connectivity between default mode network and the basal ganglia in patients with epilepsy

Epilepsy & Behavior ◽

10.1016/j.yebeh.2010.01.140 ◽

2010 ◽

Vol 17 (4) ◽

pp. 613

Author(s):

J. Tomcik ◽

M. Mikl ◽

R. Marecek ◽

M. Brazdil ◽

I. Rektor

Keyword(s):

Basal Ganglia ◽

Functional Connectivity ◽

Default Mode Network ◽

Default Mode ◽

Patients With Epilepsy

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Mapping the subcortical connectivity of the human default mode network

10.1101/2021.07.13.452265 ◽

2021 ◽

Author(s):

Jian Li ◽

William H. Curley ◽

Bastien Guerin ◽

Darin D. Dougherty ◽

Adrian V. Dalca ◽

...

Keyword(s):

Basal Ganglia ◽

Default Mode Network ◽

Basal Forebrain ◽

Ex Vivo ◽

7 Tesla ◽

Human Consciousness ◽

Connectivity Map ◽

Caudate Nuclei ◽

Default Mode ◽

Human Connectome Project

The default mode network (DMN) mediates self-awareness and introspection, core components of human consciousness. Therapies to restore consciousness in patients with severe brain injuries have historically targeted subcortical sites in the brainstem, thalamus, hypothalamus, basal forebrain, and basal ganglia, with the goal of reactivating cortical DMN nodes. However, the subcortical connectivity of the DMN has not been fully mapped and optimal subcortical targets for therapeutic neuromodulation of consciousness have not been identified. In this work, we created a comprehensive map of DMN subcortical connectivity by combining high-resolution functional and structural datasets with advanced signal processing methods. We analyzed 7 Tesla resting-state functional MRI (rs-fMRI) data from 168 healthy volunteers acquired in the Human Connectome Project. The rs-fMRI blood-oxygen-level-dependent (BOLD) data were temporally synchronized across subjects using the BrainSync algorithm. Cortical and subcortical DMN nodes were jointly analyzed and identified at the group level by applying a novel Nadam-Accelerated SCAlable and Robust (NASCAR) tensor decomposition method to the synchronized dataset. The subcortical connectivity map was then overlaid on a 7 Tesla 100 micron ex vivo MRI dataset for neuroanatomic analysis using automated segmentation of nuclei within the brainstem, thalamus, hypothalamus, basal forebrain, and basal ganglia. We further compared the NASCAR subcortical connectivity map with its counterpart generated from canonical seed-based correlation analyses. The NASCAR method revealed that BOLD signal in the central lateral nucleus of the thalamus and ventral tegmental area of the midbrain is strongly correlated with that of the DMN. In an exploratory analysis, additional subcortical sites in the median and dorsal raphe, lateral hypothalamus, and caudate nuclei were correlated with the cortical DMN. We also found that the putamen and globus pallidus are negatively correlated (i.e., anti-correlated) with the DMN, providing rs-fMRI evidence for the mesocircuit hypothesis of human consciousness, whereby a striatopallidal feedback system modulates anterior forebrain function via disinhibition of the central thalamus. Seed-based analyses yielded similar subcortical DMN connectivity, but the NASCAR result showed stronger contrast and better spatial alignment with dopamine immunostaining data. The DMN subcortical connectivity map identified here advances understanding of the subcortical regions that contribute to human consciousness and can be used to inform the selection of therapeutic targets in clinical trials for patients with disorders of consciousness.

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