scholarly journals Stimulation and Recording of the Hippocampus Using the Same Pt-Ir Coated Microelectrodes

2021 ◽  
Vol 15 ◽  
Author(s):  
Sahar Elyahoodayan ◽  
Wenxuan Jiang ◽  
Curtis D. Lee ◽  
Xiecheng Shao ◽  
Gregory Weiland ◽  
...  
Keyword(s):  
Evoked Potentials ◽  
Spatial Resolution ◽  
Power Efficiency ◽  
Single Unit ◽  
High Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Signal To Noise ◽  
Wide Range ◽  
Noise Ratio ◽  
Improved Performance

Same-electrode stimulation and recording with high spatial resolution, signal quality, and power efficiency is highly desirable in neuroscience and neural engineering. High spatial resolution and signal-to-noise ratio is necessary for obtaining unitary activities and delivering focal stimulations. Power efficiency is critical for battery-operated implantable neural interfaces. This study demonstrates the capability of recording single units as well as evoked potentials in response to a wide range of electrochemically safe stimulation pulses through high-resolution microelectrodes coated with co-deposition of Pt-Ir. It also compares signal-to-noise ratio, single unit activity, and power efficiencies between Pt-Ir coated and uncoated microelectrodes. To enable stimulation and recording with the same microelectrodes, microelectrode arrays were treated with electrodeposited platinum-iridium coating (EPIC) and tested in the CA1 cell body layer of rat hippocampi. The electrodes’ ability to (1) inject a large range of electrochemically reversable stimulation pulses to the tissue, and (2) record evoked potentials and single unit activities were quantitively assessed over an acute time period. Compared to uncoated electrodes, EPIC electrodes recorded signals with higher signal-to-noise ratios (coated: 9.77 ± 1.95 dB; uncoated: 1.95 ± 0.40 dB) and generated lower voltages (coated: 100 mV; uncoated: 650 mV) for a given stimulus (5 μA). The improved performance corresponded to lower energy consumptions and electrochemically safe stimulation above 5 μA (>0.38 mC/cm2), which enabled elicitation of field excitatory post synaptic potentials and population spikes. Spontaneous single unit activities were also modulated by varying stimulation intensities and monitored through the same electrodes. This work represents an example of stimulation and recording single unit activities from the same microelectrode, which provides a powerful tool for monitoring and manipulating neural circuits at the single neuron level.

Spiral CT of the pancreas

1998 ◽  
Vol 39 (1) ◽  
pp. 60-63 ◽  
Author(s):  
T. Nishiharu ◽  
Y. Yamashita ◽  
I. Ogata ◽  
S. Sumi ◽  
K. Mitsuzaki ◽  
...  
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Spiral Ct ◽  
Reconstruction Technique ◽  
Signal To Noise ◽  
Standard Size ◽  
Noise Ratio ◽  
Good Signal

Purpose: to compare the value of a retrospective targeted high-resolution spiral CT to the standard reconstruction technique in the assessment of pancreatic diseases Material and Methods: Spiral CT pancreatic images of a standard-size reconstruction protocol were compared prospectively with those of a retrospective targeted high-spatial-resolution reconstruction protocol in 30 patients. Prior to clinical evaluation, a phantom study was performed to evaluate the spatial resolution and signal-to-noise ratio of both protocols Results: the high-resolution protocol achieved a good signal-to-noise ratio with acceptable spatial resolution. Phantom studies revealed increased image noise (+17%) with an increase in spatial resolution (+100%). in patients studied with the high-resolution protocol, the increase in noise was not significant but there was a marked improvement in the definition of small details Conclusion: Images obtained with a targeted high-spatial-resolution reconstruction protocol showed superior lesion definition and vascular opacification compared with those obtained with a standard-size reconstruction protocol. This technique may have potential in the evaluation of small pancreatic abnormalities

scholarly journals Fast and High-Resolution Neonatal Brain MRI Through Super-Resolution Reconstruction From Acquisitions With Variable Slice Selection Direction

2021 ◽  
Vol 15 ◽  
Author(s):  
Yao Sui ◽  
Onur Afacan ◽  
Ali Gholipour ◽  
Simon K. Warfield
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Brain Mri ◽  
Super Resolution ◽  
Neonatal Brain ◽  
Signal To Noise ◽  
High Quality ◽  
Noise Ratio

The brain of neonates is small in comparison to adults. Imaging at typical resolutions such as one cubic mm incurs more partial voluming artifacts in a neonate than in an adult. The interpretation and analysis of MRI of the neonatal brain benefit from a reduction in partial volume averaging that can be achieved with high spatial resolution. Unfortunately, direct acquisition of high spatial resolution MRI is slow, which increases the potential for motion artifact, and suffers from reduced signal-to-noise ratio. The purpose of this study is thus that using super-resolution reconstruction in conjunction with fast imaging protocols to construct neonatal brain MRI images at a suitable signal-to-noise ratio and with higher spatial resolution than can be practically obtained by direct Fourier encoding. We achieved high quality brain MRI at a spatial resolution of isotropic 0.4 mm with 6 min of imaging time, using super-resolution reconstruction from three short duration scans with variable directions of slice selection. Motion compensation was achieved by aligning the three short duration scans together. We applied this technique to 20 newborns and assessed the quality of the images we reconstructed. Experiments show that our approach to super-resolution reconstruction achieved considerable improvement in spatial resolution and signal-to-noise ratio, while, in parallel, substantially reduced scan times, as compared to direct high-resolution acquisitions. The experimental results demonstrate that our approach allowed for fast and high-quality neonatal brain MRI for both scientific research and clinical studies.

Spatial resolution and signal-to-noise ratio in x-ray imaging

2019 ◽  
Author(s):  
Timur Gureyev ◽  
David M. Paganin ◽  
Alex Kozlov ◽  
Harry Quiney
Keyword(s):  
Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Signal To Noise ◽  
X Ray ◽  
X Ray Imaging ◽  
Noise Ratio

k-Space filtering in 2D gradient-echo breath-hold hyperpolarized3He MRI: Spatial resolution and signal-to-noise ratio considerations

2002 ◽  
Vol 47 (4) ◽  
pp. 687-695 ◽  
Author(s):  
Jim M. Wild ◽  
Martyn N.J. Paley ◽  
Magalie Viallon ◽  
Wolfgang G. Schreiber ◽  
Edwin J.R. van Beek ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Signal To Noise Ratio ◽  
Breath Hold ◽  
Gradient Echo ◽  
Signal To Noise ◽  
Noise Ratio

scholarly journals Parametric analysis of the spatial resolution and signal-to-noise ratio in super-resolved spatiotemporally encoded (SPEN) MRI

2013 ◽  
Vol 72 (2) ◽  
pp. 418-429 ◽  
Author(s):  
Noam Ben-Eliezer ◽  
Yoav Shrot ◽  
Lucio Frydman ◽  
Daniel K. Sodickson
Keyword(s):  
Spatial Resolution ◽  
Parametric Analysis ◽  
Signal To Noise Ratio ◽  
Signal To Noise ◽  
Noise Ratio

scholarly journals Analysis of Signal to Noise Ratio in Coronagraph Observations of Coronal Mass Ejections

2020 ◽  
Author(s):  
Johannes Hinrichs ◽  
Jackie A. Davies ◽  
Matthew J. West ◽  
Volker Bothmer ◽  
Bram Bourgoignie ◽  
...  
Keyword(s):  
Coronal Mass Ejections ◽  
Signal To Noise Ratio ◽  
European Space Agency ◽  
Leading Edge ◽  
Outer Edge ◽  
Field Of View ◽  
Signal To Noise ◽  
Space Agency ◽  
Noise Ratio ◽  
Improved Performance

<p>Aims. We analyse the Signal-to-Noise Ratio (SNR) requirements of the European Space Agency (ESA)-funded Solar Coronagraph for OPErations (SCOPE) instrument with respect to the manual and automatic detection of Coronal Mass Ejections (CMEs) in its field of view of 2.5 to 30 solar radii.<br />Methods. For our analysis, SNR values are estimated from observations made by the C3 coronagraph on the Solar and Heliospheric Observatory (SOHO) spacecraft for a number of di erent CMEs. Additionally, we generate a series of artificial coronagraph images, each consisting of a modelled coronal background and a CME, the latter simulated using the Graduated Cylindrical Shell (GCS) model together with the SCRaytrace code available in the Interactive Data Language (IDL) SolarSoft library. Images are created with CME SNR levels between 0.5 and 10 at the outer<br />field of view (FOV) edge, generated by adding Poisson noise, and velocities between 700 km s-1 and 2800 kms-1. The images are analysed for the detectability of the CME above the noise with the automatic CME detection tool CACTus.<br />Results. We find in the analysed C3 images that CMEs near the outer edge of the field of view are typically 2%of the total brightness and have an SNR between 1 and 4 at their leading edge. The automated detection of CMEs in our simulated images by CACTus succeeded well down to SNR = 1 and for CME velocities up to 1400 kms-1. At lower SNR and higher velocity of 2100 kms-1 the detection started to break down. For SCOPE, the results from the two approaches confirm that the initial design goal of SNR = 4 would, if achieved, deliver improved performance over established data used in operations today.</p>

Efficient Response Amplification of Electrothermally Driven Resonators Using Magnets

2021 ◽  
Author(s):  
Ghanimah Abuhaimed ◽  
Nizar Jaber ◽  
Nouha Alcheikh ◽  
Mohammad I. Younis
Keyword(s):  
Parametric Excitation ◽  
Energy Demand ◽  
Signal To Noise Ratio ◽  
Ambient Pressure ◽  
Thermal Relaxation ◽  
Primary Resonance ◽  
Signal To Noise ◽  
Electrothermal Actuation ◽  
Wide Range ◽  
Noise Ratio

Abstract Micro/Nano-electromechanical systems, MEMS/NEMS-based resonators are presently an important part of a wide range of applications. However, many of these devices suffer from the low signal-to-noise ratio and the need for a large driving force. Different principles were proposed to enhance the sensitivity and improve their signal-to-noise ratios (SNR), such as bifurcations, jumps and higher-order excitation. However, these methods require special designs and high actuation voltages, which are not always available in the standard function generators and power supplies. Also, it increases the devices’ overall cost and power requirements. Furthermore, parametric excitation is explored as an option to amplify the signal at a lower cost and energy demand. However, this type of excitation requires specific geometrical settings, in addition to very low damping conditions. Electrothermal actuation is investigated to achieve excitation of primary resonance, which can be used for parametric excitation. This type of excitation is desirable due to its simplicity, robustness and ability to create large internal forces at low voltages. However, the time response is limited by the thermal relaxation time. In this work, we demonstrate the use of electromagnetic actuation to significantly amplify the response of electrothermally actuated clamped-clamped resonators at first mode (primary) resonance. At ambient pressure, experimental data show 18 times amplification of the response amplitude compared with electrothermal actuation only. The method is based on introducing a permanent magnetic field to induce an out-of-plane Lorentz-force. The results show the great potential of this technique being used for a variety of sensing and signal processing applications, especially, where a large signal-to-noise ratio is required while using low operational voltages.

Sign in / Sign up

Export Citation Format

Share Document