scholarly journals Optimized Inner-Volume 3D TSE for High-Resolution Vessel Wall Imaging of Intracranial Perforating Arteries at 7T

2021 ◽  
Vol 15 ◽  
Author(s):  
Qingle Kong ◽  
Yue Wu ◽  
Dehe Weng ◽  
Jing An ◽  
Yan Zhuo ◽  
...  

The impairment of microvessels can lead to neurologic diseases such as stroke and vascular dementia. The imaging of lumen and vessel wall of perforating arteries requires an extremely high resolution due to their small caliber size. Current imaging techniques have the difficulty in observing the wall of perforating arteries. In this study, we developed a 3D inner-volume (IV) TSE (SPACE) sequence with optimized 2D spatially selective excitation (SSE) RF pulses. The optimized SSE RF pulses were designed through a series of optimization including iterative RF pulse design, trajectory optimization, and phase convention of Carr-Purcell-Meiboom-Gill (CPMG) condition to meet the perforating arteries imaging demands. High resolution of isotropic 0.30 mm within 10 min was achieved for the black- blood images of lenticulostriate artery (LSA). The LSA lumen and vessel wall were imaged by the IV-SPACE sequence simultaneously. Images obtained by the optimized RF pulse has fewer aliasing artifacts from outside of ROI than the traditional pulse. The IV-SPACE images showed clearer delineation of vessel wall and lumen of LSA than conventional SPACE images. IV-SPACE might be a promising method for detecting microvasculopathies of cerebral vascular diseases.

2005 ◽  
Vol 12 (12) ◽  
pp. 1521-1526 ◽  
Author(s):  
SeshaSailaja Anumula ◽  
Hee Kwon Song ◽  
Alexander C. Wright ◽  
Felix W. Wehrli

2002 ◽  
Vol 15 (3) ◽  
pp. 344-351 ◽  
Author(s):  
Mohamed Ouhlous ◽  
Franck Lethimonnier ◽  
Diederik W.J. Dippel ◽  
Marc R.H.M. van Sambeek ◽  
Lambertus C.J. van Heerebeek ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0241779
Author(s):  
Martin J. Willemink ◽  
Bram F. Coolen ◽  
Hadrien Dyvorne ◽  
Philip M. Robson ◽  
Ilda Bander ◽  
...  

Accurate quantification and characterization of atherosclerotic plaques with MRI requires high spatial resolution acquisitions with excellent image quality. The intrinsically better signal-to-noise ratio (SNR) at high-field clinical 7T compared to the widely employed lower field strengths of 1.5 and 3T may yield significant improvements to vascular MRI. However, 7T atherosclerosis imaging also presents specific challenges, related to local transmit coils and B1 field inhomogeneities, which may overshadow these theoretical gains. We present the development and evaluation of 3D, black-blood, ultra-high resolution vascular MRI on clinical high-field 7T in comparison lower-field 3T. These protocols were applied for in vivo imaging of atherosclerotic rabbits, which are often used for development, testing, and validation of translatable cardiovascular MR protocols. Eight atherosclerotic New Zealand White rabbits were imaged on clinical 7T and 3T MRI scanners using 3D, isotropic, high (0.63 mm3) and ultra-high (0.43 mm3) spatial resolution, black-blood MR sequences with extensive spatial coverage. Following imaging, rabbits were sacrificed for validation using fluorescence imaging and histology. Image quality parameters such as SNR and contrast-to-noise ratio (CNR), as well as morphological and functional plaque measurements (plaque area and permeability) were evaluated at both field strengths. Using the same or comparable imaging parameters, SNR and CNR were in general higher at 7T compared to 3T, with a median (interquartiles) SNR gain of +40.3 (35.3–80.1)%, and a median CNR gain of +68.1 (38.5–95.2)%. Morphological and functional parameters, such as vessel wall area and permeability, were reliably acquired at 7T and correlated significantly with corresponding, widely validated 3T vessel wall MRI measurements. In conclusion, we successfully developed 3D, black-blood, ultra-high spatial resolution vessel wall MRI protocols on a 7T clinical scanner. 7T imaging was in general superior to 3T with respect to image quality, and comparable in terms of plaque area and permeability measurements.


2001 ◽  
Vol 19 (6) ◽  
pp. 795-802 ◽  
Author(s):  
Shaoxiong Zhang ◽  
Thomas S Hatsukami ◽  
Nayak L Polissar ◽  
Chao Han ◽  
Chun Yuan

2016 ◽  
Vol 45 (2) ◽  
pp. 515-524 ◽  
Author(s):  
Masami Yoneyama ◽  
Masanobu Nakamura ◽  
Makoto Obara ◽  
Tomoyuki Okuaki ◽  
Ryuji Sashi ◽  
...  

2009 ◽  
Vol 62 (3) ◽  
pp. 607-615 ◽  
Author(s):  
Dimitris Mitsouras ◽  
Christopher D. Owens ◽  
Michael S. Conte ◽  
Hale Ersoy ◽  
Mark A. Creager ◽  
...  

Author(s):  
Konstanze V. Guggenberger ◽  
Thorsten A. Bley ◽  
Marius L. Vogt ◽  
Horst Urbach ◽  
Stephan Meckel

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