scholarly journals Bone Health in School Age Children: Effects of Nutritional Intake on Outcomes

2021 ◽  
Vol 8 ◽  
Author(s):  
Steven A. Abrams

The maximum rate of bone mass accumulation is during early adolescence. As such, a focus on optimizing mineral nutrition in school age children, defined here as approximately 5 to 15 years of age, is crucial to minimize the risk of bone loss that occurs later in life leading to osteoporosis and fractures. Optimizing bone mass in this age group requires attention to an overall healthy diet including adequate calcium, phosphorus, magnesium, and vitamin D. Special concerns may exist related to children who follow a restricted diet such as a vegan diet, those with intolerance or allergies to dairy, and those with chronic health conditions including young adolescents with eating disorders. Public policy messages should focus on positive aspects of bone health nutrition in this age group and avoid overly specific statements about the exact amounts of foods needed for healthy bones. In this regard, dietary recommendations for minerals vary between North America and Europe and these are higher than the values that may be necessary in other parts of the world. The management of many children with chronic illnesses includes the use of medications that may affect their bone mineral metabolism. Routine lab testing for bone mineral metabolism including the serum 25-hydroxyvitamin D level is not indicated, but is valuable for at-risk children, especially those with chronic illnesses.

1995 ◽  
Vol 133 (4) ◽  
pp. 412-417 ◽  
Author(s):  
Franco Antoniazzi ◽  
Francesco Bertoldo ◽  
Giorgio Zamboni ◽  
Roberta Valentini ◽  
Stefania Sirpresi ◽  
...  

Antoniazzi F, Bertoldo F, Zamboni G, Valentini R, Sirpresi S, Cavallo L, Adami S, Tatò L. Bone mineral metabolism in girls with precocious puberty during gonadotrophin-releasing hormone agonist treatment. Eur J Endocrinol 1995;133:412–7. ISSN 0804–4643 Bone mineral metabolism and mineralization before and during treatment were studied in 10 girls aged 6.9–8.4 years affected by central precocious puberty and treated with gonadotrophin-releasing hormone agonist (GnRHa) leuprolide acetate depot, in order to understand better the consequences of oestrogen deficiency and the reduction of growth hormone (GH)–insulin-like growth factor I (IGF-I) axis activity. Before and after 12 months of therapy, the patients underwent a clonidine stimulation test and a 4-day calcitriol osteoblast stimulation test. On day 0, day 5 and at 3-month intervals thereafter, serum calcium, phosphate, alkaline phosphatase, IGF-I, IGF binding protein 3 (IGFBP-3), GH, GH binding protein and osteocalcin levels were measured; urinary calcium, phosphate and hydroxyproline levels were evaluated in fasting spot samples. Trabecular and cortical bone mass variations, measured by dual X-ray absorptiometry in the lumbar spine and by dual photon absorptiometry in the radius, respectively were evaluated before the start and after 12 months of therapy. During treatment, a decrease of serum oestradiol levels from pubertal to prepubertal levels was observed. The GH peak following clonidine diminished significantly after 1 year. Growth hormone binding protein showed a slight increase, and IGF-I and IGFBP-3 decreased, although not significantly. Osteocalcin levels decreased significantly after 9 and 12 months of treatment, but they did not change significantly after calcitriol load, either before or after GnRHa therapy. Urinary hydroxyproline decreased significantly after 12 months. Before therapy, lumbar spine and radius bone mass were high for chronological age but appropriate for bone age; after 12 months of treatment, bone mass in the lumbar spine, but not in the radius, had decreased significantly. In our patients, regression of pubertal development was associated with a reduction of trabecular bone mass, which appears to be the primary consequence of GnRHa therapy and possibly related to decreased GH secretion. Franco Antoniazzi, Clinica Pediatrica, Università di Verona, Policlinico Borgo Roma, 1-37134 Verona, Italy


2003 ◽  
Vol 41 (6) ◽  
pp. 578-580 ◽  
Author(s):  
Violetta ?wi?tkiewicz ◽  
Mariusz Wysocki ◽  
Gra?yna Odrow??-Sypniewska ◽  
Andrzej Koltan ◽  
Slawomir Manysiak ◽  
...  

1998 ◽  
Vol 46 (11) ◽  
pp. 1418-1422 ◽  
Author(s):  
Horace M. Perry ◽  
Marie Bernard ◽  
Michael Horowitz ◽  
Douglas K. Miller ◽  
Shantiel Fleming ◽  
...  

1986 ◽  
Vol 39 (4) ◽  
pp. 230-233 ◽  
Author(s):  
F. Ismail ◽  
S. Epstein ◽  
R. Pacifici ◽  
D. Droke ◽  
S. B. Thomas ◽  
...  

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