scholarly journals Clinical and Dermoscopic Factors for the Identification of Aggressive Histologic Subtypes of Basal Cell Carcinoma

2021 ◽  
Vol 10 ◽  
Author(s):  
Riccardo Pampena ◽  
Gabriele Parisi ◽  
Mattia Benati ◽  
Stefania Borsari ◽  
Michela Lai ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Multivariate Regression Analysis ◽  
Histologic Subtype ◽  
Logistic Regression Models ◽  
Surgical Recurrence ◽  
Study Results ◽  
Before And After ◽  
Histologic Subtypes

BackgroundInfiltrative basal cell carcinoma (BCC) has a higher risk for post-surgical recurrence as compared to the most common low-aggressive superficial and nodular BCC. Independent diagnostic criteria for infiltrative BCC diagnosis have not been still defined. Improving the pre-surgical recognition of infiltrative BCC might significantly reduce the risk of incomplete excision and recurrence.ObjectiveThe aim of this study is to define clinical and dermoscopic criteria that can differentiate infiltrative BCC from the most common low-aggressive superficial and nodular BCC.MethodsClinical and dermoscopic images of infiltrative, superficial, and nodular BCC were retrospectively retrieved from our database and jointly evaluated by two experienced dermoscopists, blinded for the histologic subtype. Pairwise comparisons between the three histologic subtypes were performed and multivariable logistic regression models were constructed in order to define clinical and dermoscopic factors independently associated with each subtype. To validate our findings, two experienced dermoscopists not previously involved in the study were asked to evaluate clinical and dermoscopic images from an external dataset, guessing the proper BCC subtype between infiltrative, nodular and superficial, before and after being provided with the study results.ResultA total of 481 histopathologically proven BCCs (51.4% nodular, 33.9% superficial, and 14.8% infiltrative) were included. We found that infiltrative BCC mostly appeared on the head and neck as an amelanotic hypopigmented plaque or papule, displaying ulceration on dermoscopic examination, along with arborizing and fine superficial telangiectasia. Shiny white structures were also frequently observed. Multivariate regression analysis allowed us to define a clinical-dermoscopic profile of infiltrative BCC.ConclusionsWe defined the clinical-dermoscopic profile of infiltrative BCC, allowing to differentiate this variant from superficial and nodular BCC. This will improve pre-surgical recognition of infiltrative forms, reducing the risk for post-surgical recurrence.

A 13-Year Retrospective Study of Basal Cell Carcinoma in a Canadian Dermatology Practice

2015 ◽  
Vol 20 (3) ◽  
pp. 233-240 ◽  
Author(s):  
Jason K. Rivers ◽  
Bhavik D. Mistry ◽  
Tawny Hung ◽  
Kateryna Vostretsova ◽  
Nisha Mistry
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Progenitor Cell ◽  
Anatomical Location ◽  
Descriptive Data ◽  
Anatomical Distribution ◽  
The Relationship ◽  
Head Neck ◽  
Histologic Subtypes

Background: It is unknown whether the histologic subtypes of basal cell carcinoma (BCC) arise from a common progenitor cell or whether other factors play a role in their development. Objective: To investigate the relationship between the different BCC histopathologic subtypes and anatomical distribution of BCCs in a Canadian dermatology practice. Methods: The charts of all patients diagnosed with BCC between 1993 and 2005 from a single private dermatology practice in Vancouver, Canada, were reviewed. Descriptive data analysis was undertaken to look at the distribution of histologic subtypes based on age, gender, and anatomical location. Results: Nodular BCCs accounted for 58% of all tumors. Sixty-six percent of these were situated on the head/neck (odds ratio [OR] = 3.0, 95% confidence interval [CI] = 2.1-4.3, P < .0001). Infiltrative (OR = 2.4, 95% CI = 1.5-4.1, P = .0003) and superficial BCCs were more common in women (OR = 3.7, 95% CI = 2.5-5.7, P < .0001), affected the trunk (OR = 3.2, 95% CI = 2.1-4.9, P < .0001), and appeared in younger individuals (OR = 1.8, 95% CI = 1.2-2.7, P = .004). Conclusion: Our results show a preference of distinct BCC subtypes for certain anatomical locations.

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

2015 ◽  
Vol 19 (3) ◽  
pp. 239-248 ◽  
Author(s):  
David Zloty ◽  
Lyn C. Guenther ◽  
Mariusz Sapijaszko ◽  
Kirk Barber ◽  
Joël Claveau ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Recurrence Risk ◽  
Histologic Subtype ◽  
Non Melanoma Skin Cancer ◽  
Literature Searches ◽  
Canadian Health ◽  
Canadian Health Care ◽  
History Of

Background Basal cell carcinoma (BCC) is the most common malignancy. Growth of BCCs leads to local destruction of neighbouring healthy skin and underlying tissue and can result in significant functional and cosmetic morbidity. Objective To provide guidance to Canadian health care practitioners regarding management of BCCs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying Introduction. Results Although BCCs rarely metastasize“ they can be aggressive and disfiguring. This chapter describes the natural history and prognosis of BCCs. Risk stratification is based on clinical features” including the site and size of the tumour“ its histologic subtype (nodular vs sclerosing)” and its history of recurrence. Conclusions Various options should be considered for BCC treatment” including cryosurgery” curettage” and topical or photodynamic approaches, as well as fixed-margin surgery and Mohs micrographic surgery. Stratification of recurrence risk for individual BCCs determines the most appropriate therapeutic course.

Correlation of histologic subtypes of primary basal cell carcinoma and number of Mohs stages required to achieve a tumor-free plane

1997 ◽  
Vol 37 (3) ◽  
pp. 395-397 ◽  
Author(s):  
Ida F. Orengo ◽  
Stuart J. Salasche ◽  
Jessica Fewkes ◽  
Jamil Khan ◽  
John Thornby ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Free Plane ◽  
Histologic Subtypes

Histologic subtype of treatment failures after noninvasive therapy for superficial basal cell carcinoma: An observational study

2019 ◽  
Vol 80 (4) ◽  
pp. 1022-1028 ◽  
Author(s):  
Lieke C.J. van Delft ◽  
Patty J. Nelemans ◽  
Maud H.E. Jansen ◽  
Aimee H.M.M. Arits ◽  
Marieke H. Roozeboom ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Observational Study ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histologic Subtype ◽  
Noninvasive Therapy ◽  
Superficial Basal Cell Carcinoma

scholarly journals 755-nm Alexandrite Laser for the Treatment of Non-Facial Superficial and Nodular Basal Cell Carcinoma

2020 ◽  
Vol 4 (6) ◽  
pp. 548-551
Author(s):  
Valerie Shiu ◽  
Margaret Brown ◽  
Pavela Bambekova ◽  
Jenny Yeh ◽  
Jaqueline Brogan ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Small Sample Size ◽  
High Energy ◽  
Small Sample ◽  
Control Group ◽  
Alexandrite Laser ◽  
Depth Of Penetration ◽  
Study Results

Background: There is emerging literature regarding laser therapy as a treatment for non-melanoma skin cancer, with reports of vascular selective lasers and ablative lasers showing promise in basal cell carcinoma (BCC). Objectives: To assess the efficacy of the 755-nm laser in the treatment of non-facial BCC of the superficial and nodular subtypes. To provide patients with a non-surgical option for the treatment of BCC. Methods: Nineteen veterans, each with at least one biopsy proven superficial or nodular BCC on the trunk or extremity, agreed to participate in our IRB-approved, prospective, non-randomized, open-label clinical trial. A total of 21 BCC were treated, after local anesthetization, using the 755-nm Alexandrite laser (Gentle-Lase, Candela Corporation) in a single session with a 4 mm margin. Treatment sites were re-biopsied approximately six weeks later. Results: Twenty-one of 21 treated BCC demonstrated complete histologic tumor resolution at 6-week follow-up. At six weeks, all patients had a scar, and some patients had associated crusting, scaling or ulceration. The high energy and absence of dynamic cooling in our study likely resulted in additional thermal damage to the tumors. Healing times and scar appearance were comparable to electrodesiccation and curettage sites. Limitations: Our study was limited by a small sample size, lack of a control group, and sampling of treatment sites with shave removal rather than complete excision. Conclusion: The 755-nm laser has vessel-selective properties and a greater depth of penetration compared to vascular selective lasers. Our study results suggest that the 755-nm Alexandrite laser may be an effective treatment for superficial and nodular BCC on the trunk and extremities. Further investigation is warranted. 

Ultrasound as predictor of histologic subtypes linked to recurrence in basal cell carcinoma of the skin

2014 ◽  
Vol 29 (4) ◽  
pp. 702-707 ◽  
Author(s):  
X. Wortsman ◽  
P. Vergara ◽  
A. Castro ◽  
D. Saavedra ◽  
F. Bobadilla ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histologic Subtypes
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