scholarly journals Metabolic Syndrome and Breast Cancer: Prevalence, Treatment Response, and Prognosis

2021 ◽  
Vol 11 ◽  
Author(s):  
Shuwen Dong ◽  
Zheng Wang ◽  
Kunwei Shen ◽  
Xiaosong Chen
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Treatment Response ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Treatment Side Effects ◽  
Specific Tumor ◽  
Breast Cancer Outcome ◽  
Organ Specific ◽  
Cancer Outcome

Metabolic syndrome is a type of multifactorial metabolic disease with the presence of at least three factors: obesity, diabetes mellitus, low high-density lipoprotein, hypertriglyceridemia, and hypertension. Recent studies have shown that metabolic syndrome and its related components exert a significant impact on the initiation, progression, treatment response, and prognosis of breast cancer. Metabolic abnormalities not only increase the disease risk and aggravate tumor progression but also lead to unfavorable treatment responses and more treatment side effects. Moreover, biochemical reactions caused by the imbalance of these metabolic components affect both the host general state and organ-specific tumor microenvironment, resulting in increased rates of recurrence and mortality. Therefore, this review discusses the recent advances in the association of metabolic syndrome and breast cancer, providing potential novel therapeutic targets and intervention strategies to improve breast cancer outcome.

scholarly journals Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study

2020 ◽  
Vol 182 (2) ◽  
pp. 401-409 ◽  
Author(s):  
Giuseppe Buono ◽  
Anna Crispo ◽  
Mario Giuliano ◽  
Carmine De Angelis ◽  
Francesco Schettini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metabolic Syndrome ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Breast Cancer Outcome ◽  
Cancer Outcome

scholarly journals Determinants of genetic counseling uptake and its impact on breast cancer outcome: a population-based study

2014 ◽  
Vol 144 (2) ◽  
pp. 379-389 ◽  
Author(s):  
Aurélie Ayme ◽  
Valeria Viassolo ◽  
Elisabetta Rapiti ◽  
Gérald Fioretta ◽  
Hyma Schubert ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Genetic Counseling ◽  
Population Based ◽  
Population Based Study ◽  
Breast Cancer Outcome ◽  
Cancer Outcome

scholarly journals Identification of a robust gene signature that predicts breast cancer outcome in independent data sets

BMC Cancer ◽  
2007 ◽  
Vol 7 (1) ◽  
Author(s):  
James E Korkola ◽  
Ekaterina Blaveri ◽  
Sandy DeVries ◽  
Dan H Moore ◽  
E Shelley Hwang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Signature ◽  
Data Sets ◽  
Independent Data ◽  
Breast Cancer Outcome ◽  
Cancer Outcome

Peritumoural vascular invasion: A major determinant of triple-negative breast cancer outcome

2011 ◽  
Vol 47 (10) ◽  
pp. 1537-1545 ◽  
Author(s):  
Renaud Sabatier ◽  
Jocelyne Jacquemier ◽  
François Bertucci ◽  
Benjamin Esterni ◽  
Pascal Finetti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Vascular Invasion ◽  
Triple Negative ◽  
Major Determinant ◽  
Breast Cancer Outcome ◽  
Cancer Outcome

scholarly journals PV-0044 Mastectomy or breast-conserving therapy for early breast cancer: outcome comparison of 7565 cases

2019 ◽  
Vol 133 ◽  
pp. S14-S15
Author(s):  
S. Corradini ◽  
M. Pazos ◽  
D. Reitz ◽  
S. Schönecker ◽  
M. Niyazi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Breast Conserving Therapy ◽  
Breast Cancer Outcome ◽  
Outcome Comparison ◽  
Cancer Outcome

scholarly journals Wuqinxi Qigong as an Alternative Exercise for Improving Risk Factors Associated with Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials

2019 ◽  
Vol 16 (8) ◽  
pp. 1396 ◽  
Author(s):  
Liye Zou ◽  
Yangjie Zhang ◽  
Jeffer Eidi Sasaki ◽  
Albert S. Yeung ◽  
Lin Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Randomized Controlled Trials ◽  
Disease Risk ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Controlled Trials ◽  
Positive Effects ◽  
Randomized Controlled

Background: The improvement of living standards has led to increases in the prevalence of hypokinetic diseases. In particular, multifactorial complex diseases, such as metabolic syndrome, are becoming more prevalent. Currently, developing effective methods to combat or prevent metabolic syndrome is of critical public health importance. Thus, we conducted a systematic review to evaluate the existing literature regarding the effects of Wuqinxi exercise on reducing risk factors related to metabolic syndrome. Methods: Both English- and Chinese-language databases were searched for randomized controlled trials investigating the effects of Wuqinxi on these outcomes. Meanwhile, we extracted usable data for computing pooled effect size estimates, along with the random-effects model. Results: The synthesized results showed positive effects of Wuqinxi exercise on systolic blood pressure (SBP, SMD = 0.62, 95% CI 0.38 to 0.85, p < 0.001, I2 = 24.06%), diastolic blood pressure (DBP, SMD = 0.62, 95% CI 0.22 to 1.00, p < 0.001, I2 = 61.28%), total plasma cholesterol (TC, SMD = 0.88, 95% CI 0.41 to 1.36, p < 0.001, I2 = 78.71%), triglyceride (TG, SMD = 0.87, 95% CI 0.49 to 1.24, p < 0.001, I2 = 67.22%), low-density lipoprotein cholesterol (LDL-C, SMD = 1.24, 95% CI 0.76 to 1.72, p < 0.001, I2 = 78.27%), and high-density lipoprotein cholesterol (HDL, SMD = 0.95, 95% CI 0.43 to 1.46, p < 0.001, I2 = 82.27%). In addition, regression results showed that longer-duration Wuqinxi intervention significantly improved DBP (β = 0.00016, Q = 5.72, df = 1, p = 0.02), TC (β = −0.00010, Q = 9.03, df = 1, p = 0.01), TG (β = 0.00012, Q = 6.23, df = 1, p = 0.01), and LDL (β = 0.00011, Q = 5.52, df = 1, p = 0.02). Conclusions: Wuqinxi may be an effective intervention to alleviate the cardiovascular disease risk factors of metabolic syndrome.

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