scholarly journals The Emerging Landscape of Long Non-Coding RNAs in Colorectal Cancer Metastasis

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhiming Liao ◽  
Hui Nie ◽  
Yutong Wang ◽  
Jingjing Luo ◽  
Jianhua Zhou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Molecular Markers ◽  
Cancer Metastasis ◽  
Gastrointestinal Cancers ◽  
Malignant Phenotype ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Colorectal Cancer Metastasis ◽  
Non Coding Rnas ◽  
Patient Prognosis

Colorectal cancer (CRC) is one of the most common gastrointestinal cancers, with extremely high rates of morbidity and mortality. The main cause of death in CRC is distant metastasis; it affects patient prognosis and survival and is one of the key challenges in the treatment of CRC. Long non-coding RNAs (lncRNAs) are a group of non-coding RNA molecules with more than 200 nucleotides. Abnormal lncRNA expression is closely related to the occurrence and progression of several diseases, including cancer. Recent studies have shown that numerous lncRNAs play pivotal roles in the CRC metastasis, and reversing the expression of these lncRNAs through artificial means can reduce the malignant phenotype of metastatic CRC to some extent. This review summarizes the major mechanisms of lncRNAs in CRC metastasis and proposes lncRNAs as potential therapeutic targets for CRC and molecular markers for early diagnosis.

Sa1142 THE ROLE FOR LONG NON-CODING RNA IN COLORECTAL CANCER METASTASIS

2020 ◽  
Vol 158 (6) ◽  
pp. S-289-S-290
Author(s):  
Artin Soroosh ◽  
David Padua ◽  
Elizabeth J. Videlock ◽  
Diane Bui ◽  
Ami Patel ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Non Coding Rna ◽  
Colorectal Cancer Metastasis ◽  
Long Non Coding Rna

scholarly journals Correction to: Long non-coding RNA H19 promotes colorectal cancer metastasis via binding to hnRNPA2B1

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Yuhui Zhang ◽  
Weibin Huang ◽  
Yujie Yuan ◽  
Jin Li ◽  
Jing Wu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Non Coding Rna ◽  
Colorectal Cancer Metastasis ◽  
Long Non Coding Rna

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Exosomal microRNAs and other non-coding RNAs as colorectal cancer biomarkers: a review

Mutagenesis ◽  
2019 ◽  
Vol 35 (3) ◽  
pp. 243-260 ◽  
Author(s):  
Antonio Francavilla ◽  
Szimonetta Turoczi ◽  
Sonia Tarallo ◽  
Pavel Vodicka ◽  
Barbara Pardini ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Expression Profiles ◽  
Predictive Markers ◽  
Circular Rnas ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Prognostic And Predictive Markers

Abstract The circulating human transcriptome, which includes both coding and non-coding RNA (ncRNA) molecules, represents a rich source of potential biomarkers for colorectal cancer (CRC) that has only recently been explored. In particular, the release of RNA-containing extracellular vesicles (EVs), in a multitude of different in vitro cell systems and in a variety of body fluids, has attracted wide interest. The role of RNA species in EVs is still not fully understood, but their capacity to act as a form of distant communication between cells and their higher abundance in association with cancer demonstrated their relevance. In this review, we report the evidence from both in vitro and human studies on microRNAs (miRNAs) and other ncRNA profiles analysed in EVs in relation to CRC as diagnostic, prognostic and predictive markers. The studies so far highlighted that, in exosomes, the most studied category of EVs, several miRNAs are able to accurately discriminate CRC cases from controls as well as to describe the progression of the disease and its prognosis. Most of the time, the in vitro findings support the miRNA profiles detected in human exosomes. The expression profiles measured in exosomes and other EVs differ and, interestingly, there is a variability of expression also among different subsets of exosomes according to their proteic profile. On the other hand, evidence is still limited for what concerns exosome miRNAs as early diagnostic and predictive markers of treatment. Several other ncRNAs that are carried by exosomes, mostly long ncRNAs and circular RNAs, seem also to be dysregulated in CRC. Besides various technical challenges, such as the standardisation of EVs isolation methods and the optimisation of methodologies to characterise the whole spectrum of RNA molecules in exosomes, further studies are needed in order to elucidate their relevance as CRC markers.

scholarly journals MiR-581/SMAD7 Axis Contributes to Colorectal Cancer Metastasis: A Bioinformatic and Experimental Validation-Based Study

2020 ◽  
Vol 21 (18) ◽  
pp. 6499
Author(s):  
Xiaojuan Zhao ◽  
Shuzhen Liu ◽  
Bianbian Yan ◽  
Jin Yang ◽  
Erfei Chen
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Epithelial To Mesenchymal Transition ◽  
Poor Prognostic Factor ◽  
Mesenchymal Transition ◽  
Colorectal Cancer Metastasis ◽  
Potential Factor ◽  
Sw480 Cells ◽  
Non Coding Rnas ◽  
Suppress Cell Proliferation

Metastasis is a well-known poor prognostic factor and primary cause of mortality in patients with colorectal cancer (CRC). Recently, with the progress of high through-put sequencing, aberrantly expressed non-coding RNAs (ncRNAs) were found to participate in the initiation and development of cancer. However, the mechanisms of ncRNA-mediated regulation of metastasis in CRC remain largely unknown. In this study, we systematically analyzed the expression network of microRNAs (miRNAs) and genes in CRC metastasis using bioinformatics, and discovered that the miR-581/SMAD7 axis could be a potential factor that drives CRC metastasis. A dual luciferase report assay and protein analysis confirmed the binding relationship between miR-581 and SMAD7. Further functional assays revealed that miR-581 inhibition could suppress cell proliferation and induce apoptosis in SW480 cells. Up-regulation or down-regulation of miR-581 could both affect cell invasion capacity and modulate epithelial to mesenchymal transition (EMT) via a SMAD7/TGFβ signaling pathway. In conclusion, our findings elucidated that miR-581/SMAD7 could be essential for CRC metastasis, and may serve as a potential therapeutic target for CRC patients.

scholarly journals Long non-coding RNA TUG1 promotes colorectal cancer metastasis via EMT pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (32) ◽  
pp. 51713-51719 ◽  
Author(s):  
Liang Wang ◽  
Zhenxian Zhao ◽  
Weidong Feng ◽  
Zhijun Ye ◽  
Weigang Dai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Metastasis ◽  
Non Coding Rna ◽  
Colorectal Cancer Metastasis ◽  
Long Non Coding Rna

Dual Role of microRNAs in Autophagy of Colorectal Cancer

2020 ◽  
Vol 20 ◽  
Author(s):  
Tanu Sharma ◽  
James A. Radosevich ◽  
Chandi C. Mandal
Keyword(s):  
Colorectal Cancer ◽  
Cancer Progression ◽  
Cancer Metastasis ◽  
Dual Role ◽  
Rna Molecules ◽  
Non Coding Rna ◽  
Evolutionarily Conserved ◽  
Attractive Therapeutic Target ◽  
Mirnas Expression

: Autophagy is an evolutionarily conserved pathway that eliminates unwanted proteins out of the cell and increases cell survival. But dysfunctional autophagy is associated with cancer progression, cellular adaptation, cancer metastasis and makes it an attractive therapeutic target. MicroRNAs (miRNAs) are small single-stranded non-coding RNA molecules that usually bind to 3’UTR of mRNAs. This interaction eventually inhibits protein synthesis by repressing translation and/or by degrading mRNAs. miRNAs play a crucial role in the regulation of autophagy and also behave as both tumor suppressors and promoters in colorectal cancer. This paper defines an overall molecular view of how miRNAs regulate the dual role of autophagy in colorectal cancer. It also highlights how long non-coding RNAs modulate miRNAs expression to regulate autophagy in colorectal cancer. Thus, targeting autophagy by miRNAs seems to be a potential therapeutic strategy for colorectal cancer.

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