scholarly journals FSCN1 Promotes Radiation Resistance in Patients With PIK3CA Gene Alteration

2021 ◽  
Vol 11 ◽  
Author(s):  
Sisi Li ◽  
Xiao-ting Huang ◽  
Meng-yao Wang ◽  
Dong-ping Chen ◽  
Ming-yi Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Clinical Efficacy ◽  
Neck Cancer ◽  
Radiation Resistance ◽  
Poor Prognosis ◽  
Pik3ca Mutation

Radiotherapy is one of the standard treatments for cervical cancer and head and neck cancer. However, the clinical efficacy of this treatment is limited by radioresistance. The discovery of effective prognostic biomarkers and the identification of new therapeutic targets have helped to overcome the problem of radioresistance. In this study, we show that in the context of PIK3CA mutation or amplification, high expression of fascin actin-bundling protein 1 (FSCN1) (using the median as the cut-off value) is associated with poor prognosis and radiotherapy response in cancer patients. Silencing FSCN1 enhances radiosensitivity and promotes apoptosis in cancer cells with PIK3CA alterations, and this process may be associated with the downregulation of YWHAZ. These results reveal that FSCN1 may be a key regulator of radioresistance and could be a potential target for improving radiotherapy efficacy in cervical cancer and head and neck cancer patients with PIK3CA alterations.

Significance of Ferritin as a Marker in Head and Neck Malignancies

1987 ◽  
Vol 73 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Jyotsna M. Bhatavdekar ◽  
Hemangini H. Vora ◽  
Anjali Goyal ◽  
Neelam G. Shah ◽  
Nilkamal H. Karelia ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Poor Prognosis ◽  
Ferritin Level ◽  
Normal Subjects ◽  
Head And Neck Malignancies ◽  
Valuable Adjunct ◽  
The Mean

The efficiency of the combination of two tumor-associated antigens in recognising head and neck cancer was evaluated. The markers studied were CEA and ferritin by radioimmunoassay. CEA was estimated in 22 controls and 41 head and neck cancer patients. There was no difference in CEA values of controls and head and neck cancer patients, suggesting that CEA was not specific for head and neck malignancies. We measured serum ferritin in 27 controls and 58 patients with head and neck cancer. The mean ferritin level was significantly higher in patients (P < 0.001) than in normal subjects. The ferritin level in patients with no evidence of clinical disease 8 months after treatment showed approximately normal levels, whereas the levels showed a tendency to increase or remain at high levels in patients with a poor prognosis, giving support to the contention that ferritin may prove to be a valuable adjunct in head and neck cancer.

scholarly journals CTLA-4+ Regulatory T Cells Increased in Cetuximab-Treated Head and Neck Cancer Patients Suppress NK Cell Cytotoxicity and Correlate with Poor Prognosis

2015 ◽  
Vol 75 (11) ◽  
pp. 2200-2210 ◽  
Author(s):  
Hyun-Bae Jie ◽  
Patrick J. Schuler ◽  
Steve C. Lee ◽  
Raghvendra M. Srivastava ◽  
Athanassios Argiris ◽  
...  
Keyword(s):  
T Cells ◽  
Head And Neck Cancer ◽  
Regulatory T Cells ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Poor Prognosis ◽  
Nk Cell ◽  
Cell Cytotoxicity ◽  
Nk Cell Cytotoxicity

scholarly journals Electrochemotherapy in Skin Malignancies of Head and Neck Cancer Patients: Clinical Efficacy and Aesthetic Benefits

2019 ◽  
Vol 99 (13) ◽  
pp. 1246-1252 ◽  
Author(s):  
A Bonadies ◽  
E Bertozzi ◽  
R Cristiani ◽  
F Govoni ◽  
E Migliano
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Clinical Efficacy ◽  
Neck Cancer
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