scholarly journals Appearance of Tumor Vessels in Patients With Choroidal Osteoma Using Swept-Source Optical Coherence Tomographic Angiography

2021 ◽  
Vol 11 ◽  
Author(s):  
Nan Zhou ◽  
Xiaolin Xu ◽  
Yueming Liu ◽  
Wenbin Wei ◽  
Xianzhao Peng
Keyword(s):  
Indocyanine Green ◽  
Choroidal Thickness ◽  
Indocyanine Green Angiography ◽  
Optical Coherence ◽  
Swept Source ◽  
Choroidal Osteoma ◽  
Vascular Structures ◽  
The Mean ◽  
Tomographic Angiography

ObjectiveTo report the morphologic characteristics of tumor-related vasculatures and their association with secondary choroidal neovascularization (CNV), subretinal fluid (SRF), choroidal thickness, retinal pigment epithelium (RPE) alterations, subretinal hemorrhage, and tumor decalcification in eyes with choroidal osteoma (CO), using swept-source optical coherence tomographic angiography (SS-OCTA).DesignCross-sectional observational study.ParticipantsWe included 26 patients recruited from Beijing Tongren Hospital with a diagnosis of CO, based on the presence of yellow-orange mass deep to the RPE under indirect ophthalmoscopy and occupying the choroid with well-defined margins and bone density on ultrasonography or computed tomography and focal hyperfluorescent spots with no homogeneous pattern on fluorescein angiography/indocyanine green angiography (FA/ICGA). Data were collected from April 1, 2020, to April 1, 2021, and analyzed from April 30 through May 30, 2021.MethodsApplying SS-OCTA systems operating at 1,050-nm wavelengths, eyes with CO were imaged.Main Outcome and MeasuresTumor-related vasculature in eyes with CO was characterized using multimodal imaging that included fundus photography, FA/ICGA, SS-OCT, and SS-OCTA, and the images were anatomically aligned. CO thickness was manually measured as the distance between the upper boundary of the tumor and the underlying sclerochoroidal interface on the SS-OCT images. Subfoveal choroidal thickness was manually measured as the distance between the Bruch membrane and the sclerochoroidal interface on the SS-OCT images.ResultsOf the 26 Asian patients, 16 (62%) were women and 10 (38%) were men. The mean age was 26.8 years (median, 23; range, 8–45 years), and the mean best corrected visual acuity (BCVA) was 20/40. Thirty-three eyes underwent imaging and were diagnosed with CO. Indocyanine green angiography identified inhomogeneous hyperfluorescence due to tumor-related vasculature, and all corresponded to the structures that appeared as sea-fan vascular networks (SFVNs) combined with clusters of tangled vessels on SS-OCTA images. SFVNs were detected on SS-OCTA imaging in all eyes (100%), terminal tangled vascular structures in 32 of 33 eyes (97%), but not identified on ICGA. Of the 33 tangled vascular structures, 32 (97%) were located at the edge of or inside the tumor, and only 1 (3%) was associated with type 2 neovascularization. In addition, SS-OCT revealed SRF in 33 eyes (100%), 33 (100%) were located at the edge of CO, and only 1 was underlying macular. SRF with retinal edema was seen in 30 of 32 eyes (94%).ConclusionsIn eyes with CO undergoing SS-OCTA imaging, tumor-related vasculature appears as SFVNs combined with tangled vascular structures or few type 2 neovascularization. The identification of actual tumor vasculature in patients with CO as SFVNs with inner or terminal vascular tangles rather than previously described CNV may help facilitate understanding of their pathogenesis, tumor control, and response to treatment.

Choroidal thickness and vascular density in macular telangiectasia type 2 using enface swept-source optical coherence tomography

2019 ◽  
Vol 103 (11) ◽  
pp. 1584-1589 ◽  
Author(s):  
Jay C Wang ◽  
Inês Laíns ◽  
Patrick Oellers ◽  
Ivana K Kim ◽  
Joan W Miller ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Fundus Photography ◽  
Imaging Features ◽  
Optical Coherence ◽  
Swept Source ◽  
Macular Telangiectasia ◽  
Macular Telangiectasia Type 2 ◽  
And Control

PurposeTo investigate the choroidal thickness (CT) and choroidal vascular densities (CVD) of patients with macular telangiectasia type 2 (MacTel2) and their association with other multimodal imaging features, using swept-source optical coherence tomography (SS-OCT).MethodsProspective, cross-sectional study. Consecutive patients with MacTel2 along with controls without any macular disease were included. Fundus photography, confocal blue reflectance, near-infrared reflectance, autofluorescence, fluorescein angiography, spectral domain OCT and SS-OCT were performed. Images were independently analysed by two graders, and CVD was calculated from binarised en face SS-OCT images. CT was obtained from the SS-OCT platform via built-in automated segmentation. Multilevel mixed-effects models were used for statistical analysis.ResultsThirty-nine eyes of 20 patients with MacTel2 and 29 eyes of 15 control patients were included. Average CT and perifoveal temporal CT did not differ significantly between eyes with MacTel2 and control eyes (p≥0.350), when accounting for confounding factors. Overall and temporal CVD also did not significantly differ between the two groups (p≥0.490).ConclusionCT and CVD did not significantly differ between MacTel2 and control eyes in this study using SS-OCT. Even though MacTel2 may include abnormalities involving the choroid, these are likely minor in comparison to the predominant retinal changes.

scholarly journals Choroidal thickness measured using swept-source optical coherence tomography is reduced in patients with type 2 diabetes

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0191977 ◽  
Author(s):  
Beatriz Abadia ◽  
Ines Suñen ◽  
Pilar Calvo ◽  
Francisco Bartol ◽  
Guayente Verdes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Swept Source

scholarly journals Pachychoroid as a biomarker using optical coherence tomography – swept-source in central serous choroidopathy

2019 ◽  
Vol 2 ◽  
pp. 3
Author(s):  
René Alfredo Cano-Hidalgo ◽  
Tatiana Urrea-Victoria
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Thickness ◽  
Invasive Technique ◽  
Optical Coherence ◽  
Horizontal Section ◽  
Swept Source ◽  
Non Invasive ◽  
The Mean ◽  
Foveal Center ◽  
Fellow Eyes

Objective The objective of the study was to describe and evaluate the subfoveal choroidal thickness (SFCT) in the fellow eyes of patients with central serous chorioretinopathy (CSC) using swept source optical coherence tomography (SS-OCT). Methods This was a transversal, retrospective, and observational study. The SFCT was measured in patients with unilateral CSC using SS-OCT. The choroidal thickness in symptomatic and fellow eyes was measured using the attached measuring software in SS-OCT. The SFCT dimension was obtained from the horizontal section under the foveal center from the OCT data and these data were analyzed. Results The mean age of subjects undergoing imaging SS-OCT was 44.23 years old (standard deviation, 11.57). 30 out of 60 patients (63.3%) were men, and 20 (33.3%) patients had acute clinical disease. The median choroidal thicknesses of the affected eyes were greater than those of the unaffected fellow eyes (P = 0.06). The choroidal thickness measured in 120 eyes of (60 patients) was 421 µm (interquartile range 352–490), which was greater than the choroidal thickness reported in normal eyes. Conclusions The measuring of the choroidal thickness using SS-OCT is useful as a non-invasive technique to evaluate the subclinical choroidal abnormalities in CSC.

scholarly journals Differences in Choroidal Structures Between Idiopathic and Steroid-Induced Central Serous Chorioretinopathy

2018 ◽  
Vol 3 (1) ◽  
pp. 10-15
Author(s):  
Takahiko Izumi ◽  
Hideki Koizumi ◽  
Yohei Takahashi ◽  
Ichiro Maruko ◽  
Shozo Sonoda ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Layer Thickness ◽  
Central Serous Chorioretinopathy ◽  
Choroidal Thickness ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
The Mean ◽  
Binarization Method ◽  
Pathophysiologic Mechanisms

Purpose: The purpose of this article is to investigate the differences in intrachoroidal structures between eyes with idiopathic central serous chorioretinopathy (CSC) and those with steroid-induced CSC. Methods: Thirty eyes of 30 patients with idiopathic CSC and 17 eyes of 15 patients with steroid-induced CSC were studied. Cross-sectional swept-source optical coherence tomography images of eyes with idiopathic and steroid-induced CSC were retrospectively analyzed by the manual layer delineation technique and by the binarization technique. Results: The mean subfoveal choroidal thickness (SCT) was not significantly different between the eyes with idiopathic CSC (408.0 ± 106.6 µm) and those with steroid-induced (389.9 ± 105.4 µm; P = .67) CSC. Manual layer delineation showed that the mean ratio of the large choroidal vessel layer thickness to the SCT was significantly higher in eyes with idiopathic CSC (0.874 ± 0.070) than in eyes with steroid-induced CSC (0.828 ± 0.083; P = .02). The binarization method showed that the mean ratio of the luminal areas to the choroidal areas centered at the fovea was significantly higher in eyes with idiopathic CSC (0.747 ± 0.064) than in eyes with steroid-induced CSC (0.701 ± 0.046; P = .01). Conclusion: The intrachoroidal structures in steroid-induced CSC were different from those in idiopathic CSC. These findings suggest different pathophysiologic mechanisms may be involved in the pathogenesis of these 2 entities.

scholarly journals Vascular complexity and severity of diabetic retinopathy by using swept-source optical coherence tomographic angiography

2021 ◽  
Author(s):  
Jiahui Liu ◽  
Xia Gong ◽  
Xiong Kun ◽  
Wei Wang ◽  
Yuting Li ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Cross Sectional Study ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Swept Source ◽  
Non Invasive ◽  
Capillary Plexus ◽  
Treatment Naïve ◽  
Tomographic Angiography

AbstractObjectivesTo evaluate the associations of retinal vascular complexity features with the severity of diabetic retinopathy (DR) by using non-invasive optical coherence tomographic angiography (OCTA).MethodsThis prospective cross-sectional study recruited ocular-treatment-naïve patients with type 2 diabetes mellitus registered in the community of Guangzhou, China. The OCTA was used to obtain the measurements of fractal dimension (FD) and blood vessel tortuosity (BVT) in superficial capillary plexus (SCP) and the deep capillary plexus (DCP). The univariate and multivariate linear regression was used to analyze the correlation of FD and BVT in different layers with DR severity.ResultsA total of 1282 patients (1282 eyes) were included, with a mean age of 64.2±7.8 years, 60.81% of male. The FD in DCP decreased and BVT in DCP increased in DR patients compared to non-DR patients, even after adjusting for confounding factors (P< 0.05). Trend analysis showed a significant decrease in FD values as DR progresses, while the BVT progressively increased with worsening DR severity (P< 0.01).ConclusionThe FD and BVT determined using OCTA might be useful parameters for objectively distinguishing DR from non-DR, and indicating the DR progression.

Investigation of the Etiology of Central Serous Chorioretinopathy Using En-Face Optical Coherence Tomography and Indocyanine Green Angiography

2016 ◽  
Vol 236 (2) ◽  
pp. 100-107 ◽  
Author(s):  
Ari Shinojima ◽  
Kyoko Fujita ◽  
Ryusaburo Mori ◽  
Akiyuki Kawamura ◽  
Mitsuko Yuzawa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Central Serous Chorioretinopathy ◽  
Indocyanine Green Angiography ◽  
Late Phase ◽  
Optical Coherence ◽  
Swept Source ◽  
Face Images ◽  
En Face ◽  
Swept Source Oct

Purpose: To identify locations of hypofluorescent lesions on late-phase indocyanine green angiography (ICGA) in patients with central serous chorioretinopathy (CSC) using en-face optical coherence tomography (OCT). Procedures: We retrospectively studied 25 consecutive untreated CSC patients, using swept-source OCT and ICGA. En-face swept-source OCT images were automatically segmented and flattened with Bruch's membrane (BrM). We compared the sizes of hyperreflective areas in the 25 CSC and 25 contralateral eyes on en-face images and hypofluorescent areas on ICGA after 30 min. Results: All 25 CSC eyes and 13 contralateral eyes showed abnormal hypofluorescent areas on late-phase ICGA and hyperreflective areas on en-face OCT from BrM to the choriocapillaris, and these findings correlated with the abnormal areas (r = 0.9988; p < 0.001). Conclusions: In CSC patients, we detected abnormal hypofluorescence on ICGA in the late phase, which corresponded to abnormal hyperreflective areas from BrM to the choriocapillaris level in en-face images.

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