scholarly journals Case Report: Analysis of Inflammatory Cytokines IL-6, CCL2/MCP1, CCL5/RANTES, CXCL9/MIG, and CXCL10/IP10 in a Cystic Fibrosis Patient Cohort During the First Wave of the COVID-19 Pandemic

2021 ◽  
Vol 9 ◽  
Author(s):  
Giulia Baresi ◽  
Mauro Giacomelli ◽  
Daniele Moratto ◽  
Marco Chiarini ◽  
Immacolata Claudia Conforti ◽  
...  

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, data registered in the European countries revealed increasing cases of infection in cystic fibrosis (CF) patients. In the course of this pandemic, we enrolled 17 CF patients for a study evaluating inflammatory markers. One of them developed COVID-19, giving us the possibility to analyze inflammatory markers in the acute phase as compared to levels detected before and after the infectious episode and to levels measured in the other CF patients enrolled to the study who did not experience COVID-19 and 23 patients referred to our center for SARS-CoV-2 infection.

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Daniel Goldenberger ◽  
Vladimira Hinić ◽  
Spasenija Savic Prince ◽  
Michael Tamm ◽  
Anna-Maria Balestra ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-4 ◽  
Author(s):  
Habiba Hussain ◽  
Matthew Sehring ◽  
Bhagat Singh Aulakh

The Coronavirus disease (COVID-19) pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has led to tremendous morbidity and mortality. Various inflammatory markers have been monitored and considered to be associated with disease prognosis. One of the major sources of comorbidity involved has been development of thrombosis alongside the infection. This prothrombotic phenomenon considered, COVID-19-associated coagulopathy (CAC), has been the center of discussion in dealing with this infection. There still remains ambiguity regarding management guidelines for thromboprophylaxis dosing and therapeutic anticoagulation. We present a case of severe SARS-CoV-2 infection complicated by thrombosis despite therapeutic anticoagulation contributing to prolonged intensive care unit and hospital stay.


2020 ◽  
Vol 2 ◽  
pp. 10-10
Author(s):  
Françoise Le Pimpec-Barthes ◽  
Giuseppe Mangiameli ◽  
Ciprian Pricopi ◽  
Alex Arame ◽  
Anne Hernigou ◽  
...  

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Octavio Carretero-Vicario ◽  
Irene Taravillo ◽  
Laura Corbella ◽  
Mercedes Catalan ◽  
Cristina Garfia ◽  
...  

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Vanitha Mariappan ◽  
Surendran Thavagnanam ◽  
Kumutha Malar Vellasamy ◽  
Cindy Ju Shuan Teh ◽  
Nadia Atiya ◽  
...  

1989 ◽  
Vol 102 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Christiane Wolz ◽  
Gerd Kiosz ◽  
John W. Ogle ◽  
Michael L. Vasil ◽  
Urs Schaad ◽  
...  

SUMMARYTo investigate cross-colonization with and persistence ofPseudomonas aeruginosain cystic fibrosis (CF). 181 isolates from 76 CF patients were typed using aP. aeruginosa-specific DNA probe. Whereas sibling pairs predominantly harboured genotypically identicalP. aeruginosastrains, all of the other patients harboured different strains. Seventy-nine per cent (22/31) of the infected CF patients harboured the same strains at the beginning and the end of a summer camp. A change of strains was seen in 10% (3/31) of the patients at the end of the camp. Forty-six per cent (6/13) of the patients who were apparently initially uninfected, acquiredP. aeruginosaby the end of the period. Genotyping proved that strain change or acquisition was due to cross-colonization in four of nine cases. Very littleP. aeruginosawas isolated from the inanimate environment. Persistence ofP. aeruginosaafter a temporary loss due to antibiotic therapy was seen in 12/16 paired patient strains before and after antibiotic therapy. Thus, suppression followed a flare-up seemed to occur in these patients rather than eradication and a new infection. When 35 patients were followed over a period of 6 months, 7 (20%) changed the strain in their sputum. Only one of 43 patients harboured two differentP. aeruginosastrains simultaneously over a long period.


2008 ◽  
Vol 15 (5) ◽  
pp. 237-239 ◽  
Author(s):  
Dimas Mateos Corral ◽  
Allan L Coates ◽  
Yvonne CW Yau ◽  
Raymond Tellier ◽  
Mindy Glass ◽  
...  

Burkholderia pseudomalleiis a pathogen identified with increasing frequency in the respiratory tracts of cystic fibrosis (CF) patients from endemic areas such as Southeast Asia and northern Australia. The following report describes the first known reported case in a CF patient from the Caribbean attending a North American CF clinic.


1997 ◽  
Vol 111 (8) ◽  
pp. 760-762 ◽  
Author(s):  
Elizabeth C. Adam ◽  
Dietlind U. Schumacher ◽  
Udo Schumacher

AbstractThe ciliary beat frequency measurements taken from a nasal polyp from a cystic fibrosis patient were similar to that of the control nasal polyps. The addition of a ciliotoxic lectin produced byPseudomonas aeruginosastopped the beating of the cilia as in the controls. This reaction could be blocked by the pre-incubation of the lectin with its inhibitor fucose. As in the control, the addition of fucose after the cilia had slowed resulted in a return to normal ciliary beating within 24 hours. This shows that the delta F508 CF mutation observed in this patient does not affect ciliary beating and suggests that treatment with fucose in the early stages of aPseudomonas aeruginosainfection could be advantageous for cystic fibrosis patients.


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