scholarly journals The Influence of Perioperative Antibiotic Prophylaxis on Wound Infection and on the Colonization of Wound Drains in Patients After Correction of Craniosynostosis

2021 ◽  
Vol 9 ◽  
Author(s):  
Johannes Holle ◽  
Tobias Finger ◽  
Julia Lugonja ◽  
Florian Schmidt ◽  
Andreas Schaumann ◽  
...  
Keyword(s):  
Treatment Group ◽  
Antibiotic Prophylaxis ◽  
Wound Infection ◽  
Infection Rate ◽  
Laboratory Data ◽  
Wound Infection Rate ◽  
Colonization Rate ◽  
Single Shot ◽  
Perioperative Antibiotic Prophylaxis ◽  
Minimal Rate

Objective: Evidence for the duration of perioperative antibiotic prophylaxis (PAP) after the correction of craniosynostosis in children is scarce. We evaluated the necessary duration of PAP to ensure a minimal rate of postoperative wound infections.Methods: In this monocentric, retrospective, and prospective pilot study, two PAP protocols were compared. From August 2017 to May 2018, treatment group 1 (TG 1) was treated using the standard PAP protocol with at least three doses of antibiotics. Between May 2018 and March 2019, a shortened PAP with a single-shot administration was given to treatment group 2 (TG 2a and b). Endpoints of this study were wound infection rate, colonization rate of wound drains, and the course of treatment reflected by clinical and laboratory data.Results: A cohort of 187 children underwent craniosynostosis correction: 167 were treated according to protocols-−95 patients with at least three doses (TG 1) and 72 patients with a single-shot of cefuroxime (TG 2a). Baseline characteristics were similar for both groups. We could not detect significant differences, neither for wound infection rates (TG 1: 1.1%, TG 2a: 0.0%, p = 0.38) nor for colonization rates of wound drains (TG 1: 4.8%, TG 2a: 10.5%, p = 0.27).Conclusions: Single-shot PAP had no adverse effects on the wound infection rate or the colonization rate of the wound drains compared with prolonged perioperative antibiotic prophylaxis. As a result, single-shot preoperative PAP is now applied to the majority craniosynostosis patients undergoing surgical correction in our unit.

Caesarean section wound infections and antibiotic use: a retrospective case-series in a tertiary referral hospital in The Gambia

2017 ◽  
Vol 48 (3) ◽  
pp. 192-199 ◽  
Author(s):  
Alex Aulakh ◽  
Patrick Idoko ◽  
Suzanne T Anderson ◽  
Wendy Graham
Keyword(s):  
Risk Factors ◽  
Caesarean Section ◽  
Antibiotic Prophylaxis ◽  
Wound Infection ◽  
Infection Rate ◽  
Wound Infection Rate ◽  
The Gambia ◽  
Referral Hospital ◽  
Wound Infections ◽  
Preoperative Antibiotic Prophylaxis

Ours is the first published study to examine post-Caesarean section (CS) wound infections in The Gambia. We explored risk factors and clinical management retrospectively at a large referral hospital over a 12-month period. A total of 777 cases were identified and records for 682 (88%) were retrieved. The CS rate was 21.8% and the wound infection rate 13.2%. Risk factors included: length of labour; decision-to-incision time and stillbirth. Only 7.4% of women received preoperative antibiotic prophylaxis, but all women received multiple-dose, postoperative antibiotics. The wound infection rate found is likely to be an underestimate owing to loss to follow-up. The adherence to international guidelines regarding preoperative antibiotic prophylaxis needs to be improved.

Wound Infection Rate in Dermatologic Surgery

1988 ◽  
Vol 14 (5) ◽  
pp. 525-528 ◽  
Author(s):  
DUANE C. WHITAKER ◽  
DONALD J. GRANDE ◽  
SALLY S. JOHNSON
Keyword(s):  
Wound Infection ◽  
Infection Rate ◽  
Wound Infection Rate ◽  
Dermatologic Surgery

scholarly journals Distribution and Determinant of Post-Operative Wound Infection among Patients underwent Routine Abdominal Surgery

2019 ◽  
Vol 6 (1) ◽  
pp. 16-21
Author(s):  
Md Mafiur Rahman ◽  
SM Shafiul Azam Chaudhury ◽  
Md Atiqul Islam ◽  
Mohammad Khurshidul Alam ◽  
ABM Mir Mubinul Islam ◽  
...  
Keyword(s):  
Abdominal Surgery ◽  
Wound Infection ◽  
Infection Rate ◽  
Wound Infection Rate ◽  
Operation Theatre ◽  
Medical College ◽  
Abdominal Operations ◽  
Contaminated Wound ◽  
Clean Contaminated ◽  
Operative Wound

Background: Post-operative wound infection may occur after routine abdominal surgery. Objective: The purpose of the present study was to see the distribution and determinants of post-operative wound infection among the patients underwent routine abdominal surgery. Methodology: This non-randomized clinical trial was conducted in the different surgical units of the Department of Surgery at Sir Sallimullah Medical College & Mitford Hospital, Dhaka, Bangladesh during January 2001 to December 2002 for a period of two (02) years. In the operation theatre, after anaesthesia skin was cleaned with Povidone iodine USP 5% w/w or Spirit (70% methylated spirit in water) or Chlorhexidine. During post-operative period dressing were left undisturbed unless it was felt necessary. Unusual pain in and around the wound was considered to be an indication of infection. A swab was taken from any discharge and was sent for bacteriological examination. Result: In this study, 50 patients were admitted as routine cases and undergone routine abdominal operations in general operation theatre. Out of 50 patients undergone routine abdominal surgery, 5 developed wound infection post operatively. Overall infection rate was 10.0%. In routine abdominal operations, infection was 9.09% in upper midline or extended midline incision, 33.33% in lower midline, 6.25% right subcostal/Kocher's. In routine abdominal operations, the rate of infection in clean contaminated wound was 11.11%, contaminated wound was 33.33%. Wound infection rate was 20.0% cases in patients with malnutrition, 14.28% cases in obesity and 16.66% cases in diabetes mellitus. Conclusion: In conclusion post-operative wound infection is common in routine surgical operation. Bangladesh Journal of Infectious Diseases, June 2019;6(1):16-21

Cost Analysis of Early versus Delayed Loop Ileostomy Closure: A Case-Matched Study

2015 ◽  
Vol 32 (3) ◽  
pp. 166-172 ◽  
Author(s):  
Jason Robertson ◽  
Hannah Linkhorn ◽  
Ryash Vather ◽  
Rebekah Jaung ◽  
Ian P. Bissett
Keyword(s):  
Wound Infection ◽  
Infection Rate ◽  
Loop Ileostomy ◽  
Hospital Readmissions ◽  
Hospital Costs ◽  
Cost Effective ◽  
Wound Infection Rate ◽  
Ileostomy Closure ◽  
Total Direct Cost ◽  
Optimal Timing

Background/Aims: The optimal timing for the closure of loop ileostomies remains controversial. The aim of the current study was to investigate whether early ileostomy closure (EC) (<2 weeks post-formation) results in significant healthcare savings as against late closure (LC). Methods: Patients with available cost data that underwent EC between January 2008 and December 2012 were compared against matched patients undergoing LC during the same period. Direct hospital costs for the two groups were compared. Results: There were 42 EC patients and 61 LC patients. EC patients had significantly less ileostomy-related complications (p < 0.001) and hospital readmissions (p < 0.001). Operative time (p < 0.001) and operative cost (p = 0.002) were also both significantly less in the EC group. Community nursing costs favoured the LC group (p = 0.047). The EC group had an increased post-closure wound infection rate (p = 0.02). The mean total direct cost per patient was NZD 13,724 (SD NZD 3,736) for EC and NZD 16,728 (SD NZD 8,028) for LC. Representing an average costs saving of NZD 3,004 per patient favouring EC (p = 0.012). Conclusion: Although EC increases the post-closure wound infection rate, EC reduces ileostomy complications, hospital readmissions and operative costs resulting in significant healthcare savings. In order to improve patient outcomes and make EC even more cost effective, efforts should be taken to reduce wound infections.

Perioperative antibiotic prophylaxis and wound infection following breast surgery

1993 ◽  
Vol 31 (suppl B) ◽  
pp. 43-48 ◽  
Author(s):  
R. Platt ◽  
J. R. Zucker ◽  
D. F. Zaleznik ◽  
C. C. Hopkins ◽  
E. P. Dellinger ◽  
...  
Keyword(s):  
Antibiotic Prophylaxis ◽  
Wound Infection ◽  
Breast Surgery ◽  
Perioperative Antibiotic Prophylaxis

681: Impact of Postoperative Antibiotic Removal in Sternal Wound Infection Rate Following CABG

2020 ◽  
Vol 49 (1) ◽  
pp. 335-335
Author(s):  
Kirubel Hailu ◽  
Bryan Allen ◽  
Chad Cannon ◽  
Meseret Dabi ◽  
Dimple Patel
Keyword(s):  
Wound Infection ◽  
Infection Rate ◽  
Wound Infection Rate ◽  
Sternal Wound Infection ◽  
Antibiotic Removal

Low-Dose, Single-Shot Perioperative Antibiotic Prophylaxis in Colorectal Surgery

Chemotherapy ◽  
1997 ◽  
Vol 43 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Ch. Peiper ◽  
M. Seelig ◽  
K.-H. Treutner ◽  
V. Schumpelick
Keyword(s):  
Colorectal Surgery ◽  
Antibiotic Prophylaxis ◽  
Low Dose ◽  
Single Shot ◽  
Perioperative Antibiotic Prophylaxis

scholarly journals Safety and Efficacy for Robot-Assisted Versus Open Pancreaticoduodenectomy: A Meta-Analysis of Multiple Worldwide Centers

2020 ◽  
Author(s):  
Wei Zhang ◽  
jian wei Zhang ◽  
Xu Che
Keyword(s):  
Wound Infection ◽  
Pancreatic Fistula ◽  
Infection Rate ◽  
Random Effect ◽  
Reoperation Rate ◽  
Wound Infection Rate ◽  
Cochrane Library ◽  
Robot Assisted ◽  
Estimated Blood Loss ◽  
Open Pancreaticoduodenectomy

Abstract Objectives: To compare the efficacy of robot-assisted pancreaticoduodenectomy with that of laparotomy.Methods: The PubMed, EMBASE, Cochrane Library, and other databases were searched for literature available from their respective inception dates up to May 2020 to find studies comparing robot-assisted pancreaticoduodenectomy (RPD) with open pancreaticoduodenectomy (OPD). The RevMan 5.3 statistical software was used for analysis to evaluate surgical outcome and oncology safety. The combination ratio (RR) and weighted mean difference (WMD) and their 95% confidence intervals (CIs) were calculated using fixed effect or random effect models.Results: 18 cohort studies from 16 medical centers were eligible with a total of 5795 patients including 1420 RPD group patients and 4375 OPD group patients. The RPD group fared better than the OPD group in terms of estimated blood loss (EBL) (WMD =-175.65, 95% CI (-251.85, -99.44), P<0.00001), wound infection rate (RR=0.60, 95%CI (0.44,0.81), P= 0.001), reoperation rate (RR=0.61, 95%CI (0.41,0.91), P=0.02), hospital day (WMD = -2.95, 95% CI (-5.33,-0.56), P = 0.02), intraoperative blood transfusion (RR = 0.56, 95% CI(0.42, 0.76), P=0.0001), overall complication (RR = 0.78, 95% CI(0.64,0.95), P = 0.01), and clinical pancreatic fistula (PF) (RR = 0.54, 95% CI(0.41,0.70), P < 0.0001). In terms of lymph node clearance (WMD = 0.48, 95% CI(-2.05,3.02), P = 0.71), R0 rate (RR = 1.05, 95% CI(1.00,1.11), P = 0.05), postoperative pancreatic fistula (POPF) (RR=1, 95% CI(0.85,1.19), P = 0.97), bile leakage (RR = 0.99, 95% CI(0.54,1.83), P = 0.98), delayed gastric emptying (DGE) (RR = 0.79, 95% CI(0.60,1.03), P = 0.08), mortality (RR = 0.82, 95% CI(0.62,1.10), P=0.19), and severe complication (RR = 0.98, 95% CI(0.71,1.36), P = 0.91), there were no significant differences between the two groups. Laparoscopic surgery was inferior to open surgery in terms of operational time (WMD = 80.85, 95% CI (16.09,145.61), P=0.01).Conclusions: RPD is not inferior to OPD, and it is even more advantageous for DGE, wound infection rate, reoperation rate, hospital stay, transfusion, overall complication and clinical PF. However, these findings need to be further verified by high-quality randomized controlled trials.

Sign in / Sign up

Export Citation Format

Share Document