scholarly journals Galangin Attenuates Isoproterenol-Induced Inflammation and Fibrosis in the Cardiac Tissue of Albino Wistar Rats

2020 ◽  
Vol 11 ◽  
Author(s):  
Radhiga Thangaiyan ◽  
Sundaresan Arjunan ◽  
Kanimozhi Govindasamy ◽  
Haseeb A. Khan ◽  
Abdullah S. Alhomida ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Wistar Rats ◽  
Glycogen Synthase ◽  
Troponin T ◽  
Gene Expression Pattern ◽  
Heart Tissue ◽  
Cardioprotective Effect ◽  
Rat Serum ◽  
Creatine Kinase Mb ◽  
Anti Inflammatory

Galangin (GA) is an active flavonoid of the rhizome of Alpinia galanga that belongs to the ginger family. GA exhibit potent anti-inflammatory properties. Therefore, we evaluated the preventive effects of GA against isoproterenol (ISO)-induced inflammation and myocardial fibrosis in male albino Wistar rats. We found that GA (1 mg/kg b.wt.) pretreatment attenuated the ISO-mediated (5 mg/kg b.wt. for 14 consecutive days) elevation of heart rate, activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase-MB (CKMB) in the rat serum. We also noticed that GA prevented the ISO-mediated cardiac markers i.e. cardiac troponin T and I (cTnT and cTnI) expression in the serum of rats. Further, GA pretreatment prevented ISO-mediated lipid peroxidation and diminished blood pressure and loss of antioxidants status in the heart tissue of ISO treated rats. In addition, GA treatment modulates ISO-induced alterations the expressions of tissue inhibitor of metalloproteinases-1 (TIMP-1), p-AKT, glycogen synthase kinase-3β (p-GSK-3β) and peroxisome proliferators-activated receptor-γ (PPAR-γ) in the heart tissue. Furthermore, molecular analysis (PCR array and western blot) revealed that GA pretreatment prevented inflammation and fibrosis related gene expression pattern in ISO-induced rats. Taken together, the results indicate the cardioprotective effect of GA against ISO-induced inflammation and fibrosis. The antioxidant and anti-inflammatory potential of GA could be considered for its cardioprotective effect in the ISO-treated rats.

Protective effect of alpha-pinene against isoproterenol-induced myocardial infarction through NF-κB signaling pathway

2020 ◽  
Vol 39 (12) ◽  
pp. 1596-1606
Author(s):  
B Zhang ◽  
H Wang ◽  
Z Yang ◽  
M Cao ◽  
K Wang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Troponin ◽  
Wistar Rats ◽  
Troponin I ◽  
Troponin T ◽  
Inflammatory Marker ◽  
Heart Tissue ◽  
Alpha Pinene ◽  
Tnf Α ◽  
Anti Inflammatory

Monoterpenes present in the essential oils exhibit anti-inflammatory properties. In this study, we investigated the preventive effect of alpha-pinene (AP), a monoterpene, against isoproterenol (ISO)-induced myocardial infarction and inflammation in Wistar rats. Male Wistar rats were pretreated with AP (50 mg/kg body weight (bw)) administration for 21 days and ISO (85 mg/kg bw) was administered subcutaneously for last two consecutive days (20th day and 21st day). We noticed that there was an increased activity of cardiac marker enzymes in ISO-treated rats. We also observed that elevated levels of lipid peroxidative indices decreased activities of antioxidant status in plasma, erythrocyte, and heart tissue in ISO-induced rats. Furthermore, ISO-treated rats showed an increase in the levels of inflammatory mediators like tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the serum. Besides, we confirmed the upregulated expression of TNF-α, IL-6, and nuclear factor kappa-light-chain-enhancer of activated B cells in ISO-induced rat heart tissue. Conversely, we found that AP pretreatment significantly decreased levels of cardiac markers like serum cardiac troponin T and cardiac troponin I, lipid peroxidative markers, and restored antioxidants status in ISO-treated rats. Besides, AP administration attenuated ISO-induced inflammatory marker expression. The present findings demonstrated that AP significantly protects the myocardium and exerts cardioprotective and anti-inflammatory effects in experimental rats.

Serum Cardiac Troponin T and Creatine Kinase–MB Elevations in Murine Autoimmune Myocarditis

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1927-1932 ◽  
Author(s):  
Kurt Bachmaier ◽  
Johannes Mair ◽  
Felix Offner ◽  
Christian Pummerer ◽  
Nikolaus Neu
Keyword(s):  
Creatine Kinase ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Autoimmune Myocarditis ◽  
Creatine Kinase Mb ◽  
Serum Cardiac Troponin

Troponin T is a better predictor than creatine kinase-MB of long-term mortality after coronary artery bypass graft surgery

2012 ◽  
Vol 164 (5) ◽  
pp. 779-785 ◽  
Author(s):  
Camilla Lund Søraas ◽  
Charlotte Friis ◽  
Kristin Victoria Tunheim Engebretsen ◽  
Leiv Sandvik ◽  
Sverre Erik Kjeldsen ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Coronary Artery ◽  
Coronary Artery Bypass Graft ◽  
Troponin T ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Creatine Kinase Mb ◽  
Long Term Mortality

scholarly journals Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Anusha Chennuru ◽  
Mohamed T. S. Saleem
Keyword(s):  
Troponin T ◽  
Biochemical Study ◽  
Heart Tissue ◽  
Cardioprotective Effect ◽  
Cardiac Biomarkers ◽  
Lipid Lowering ◽  
Tissue Homogenate ◽  
Histopathological Study ◽  
Membrane Stabilization ◽  
Stabilization Effect

The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was administered to rats at a total cumulative dose of 15 mg/kg through intraperitoneal route for 2 weeks in six-divided dose on 8th, 10th, 14th, 16th, 18th, and 21st day. After the last dose administration, the endogenous antioxidants and lipid peroxidation were estimated in heart tissue homogenate. Cardiac biomarkers such as troponin T, LDH, CK, and AST and lipid profiles such as cholesterol, triglycerides, HDL, LDL, and VLDL were estimated in serum. Sesamol has cardioprotective activity through normalization of doxorubicin-induced-altered biochemical parameters. Biochemical study was further supported by histopathological study, which shows that sesamol offered myocardial protection from necrotic damage. From these findings, it has been concluded that the sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy via amelioration of oxidative stress, lipid lowering, and membrane stabilization effect.

scholarly journals A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery

2002 ◽  
Vol 39 (9) ◽  
pp. 1518-1523 ◽  
Author(s):  
James L Januzzi ◽  
Kent Lewandrowski ◽  
Thomas E MacGillivray ◽  
John B Newell ◽  
Sekar Kathiresan ◽  
...  
Keyword(s):  
Creatine Kinase ◽  
Cardiac Surgery ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Patient Evaluation ◽  
Creatine Kinase Mb
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